tetano
Editor, Senior Moderator
Vaccine. 2017 Oct 28. pii: S0264-410X(17)31481-0. doi: 10.1016/j.vaccine.2017.10.073. [Epub ahead of print]
[h=1]A multi-site feasibility study to assess fever and wheezing in children after influenza vaccines using text messaging.[/h] Stockwell MS[SUP]1[/SUP], Marchant CD[SUP]2[/SUP], Wodi AP[SUP]3[/SUP], Barnett ED[SUP]4[/SUP], Broder KR[SUP]5[/SUP], Jakob K[SUP]6[/SUP], Lewis P[SUP]7[/SUP], Kattan M[SUP]8[/SUP], Rezendes AM[SUP]9[/SUP], Barrett A[SUP]10[/SUP], Sharma D[SUP]11[/SUP], Fernandez N[SUP]12[/SUP], LaRussa P[SUP]13[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Using text messaging for vaccine safety monitoring, particularly for non-medically attended events, would be valuable for pandemic influenza and emergency vaccination program preparedness. We assessed the feasibility and acceptability of text messaging to evaluate fever and wheezing post-influenza vaccination in a prospective, observational, multi-site pediatric study.
[h=4]METHODS:[/h] Children aged 2-11 years old, with an emphasis on children with asthma, were recruited during the 2014-2015 influenza season from three community-based clinics in New York City, and during the 2014-2015 and 2015-2016 seasons from a private practice in Fall River, Massachusetts. Parents of enrolled children receiving quadrivalent live attenuated (LAIV4) or inactivated influenza vaccine (IIV4) replied to text messages assessing respiratory symptoms (day 3 and 7, then weekly through day 42), and temperature on the night of vaccination and the next seven nights (day 0-7). Missing data were collected via diary (day 0-7 only) and phone. Phone confirmation was obtained for both presence and absence of respiratory symptoms. Reporting rates, fever (T≥100.4 ?F) frequency, proportion of wheezing and/or chest tightness reports captured via text message versus all sources (text, phone, diary, electronic health record) and parental satisfaction were assessed.
[h=4]RESULTS:[/h] Across both seasons, 266 children were analyzed; 49.2% with asthma. Parental text message response rates were high (>70%) across sites. Overall, fever frequency was low (day 0-2: 4.1% [95% confidence interval (CI) 2.3-7.4%]; d3-7: 6.7% [95% CI 4.1-10.8%]). A third (39.2%) of parents reported a respiratory problem in their child, primarily cough. Most (88.2%) of the 52 wheezing and/or chest tightness reports were by text message. Most (88.1%) participants preferred text messaging over paper reporting.
[h=4]CONCLUSIONS:[/h] Text messaging can provide information about pediatric post-vaccination fever and wheezing and was viewed positively by parents. It could be a helpful tool for rapid vaccine safety monitoring during a pandemic or other emergency vaccination program.
[h=4]TRIAL REGISTRATION:[/h] clinicaltrials.gov Identifier: NCT02295007.
Copyright ? 2017 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Asthma; Influenza; Influenza vaccination; SMS; Text message; Vaccination; Vaccine safety; Wheeze
PMID: 29089191 DOI: 10.1016/j.vaccine.2017.10.073
[h=1]A multi-site feasibility study to assess fever and wheezing in children after influenza vaccines using text messaging.[/h] Stockwell MS[SUP]1[/SUP], Marchant CD[SUP]2[/SUP], Wodi AP[SUP]3[/SUP], Barnett ED[SUP]4[/SUP], Broder KR[SUP]5[/SUP], Jakob K[SUP]6[/SUP], Lewis P[SUP]7[/SUP], Kattan M[SUP]8[/SUP], Rezendes AM[SUP]9[/SUP], Barrett A[SUP]10[/SUP], Sharma D[SUP]11[/SUP], Fernandez N[SUP]12[/SUP], LaRussa P[SUP]13[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Using text messaging for vaccine safety monitoring, particularly for non-medically attended events, would be valuable for pandemic influenza and emergency vaccination program preparedness. We assessed the feasibility and acceptability of text messaging to evaluate fever and wheezing post-influenza vaccination in a prospective, observational, multi-site pediatric study.
[h=4]METHODS:[/h] Children aged 2-11 years old, with an emphasis on children with asthma, were recruited during the 2014-2015 influenza season from three community-based clinics in New York City, and during the 2014-2015 and 2015-2016 seasons from a private practice in Fall River, Massachusetts. Parents of enrolled children receiving quadrivalent live attenuated (LAIV4) or inactivated influenza vaccine (IIV4) replied to text messages assessing respiratory symptoms (day 3 and 7, then weekly through day 42), and temperature on the night of vaccination and the next seven nights (day 0-7). Missing data were collected via diary (day 0-7 only) and phone. Phone confirmation was obtained for both presence and absence of respiratory symptoms. Reporting rates, fever (T≥100.4 ?F) frequency, proportion of wheezing and/or chest tightness reports captured via text message versus all sources (text, phone, diary, electronic health record) and parental satisfaction were assessed.
[h=4]RESULTS:[/h] Across both seasons, 266 children were analyzed; 49.2% with asthma. Parental text message response rates were high (>70%) across sites. Overall, fever frequency was low (day 0-2: 4.1% [95% confidence interval (CI) 2.3-7.4%]; d3-7: 6.7% [95% CI 4.1-10.8%]). A third (39.2%) of parents reported a respiratory problem in their child, primarily cough. Most (88.2%) of the 52 wheezing and/or chest tightness reports were by text message. Most (88.1%) participants preferred text messaging over paper reporting.
[h=4]CONCLUSIONS:[/h] Text messaging can provide information about pediatric post-vaccination fever and wheezing and was viewed positively by parents. It could be a helpful tool for rapid vaccine safety monitoring during a pandemic or other emergency vaccination program.
[h=4]TRIAL REGISTRATION:[/h] clinicaltrials.gov Identifier: NCT02295007.
Copyright ? 2017 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Asthma; Influenza; Influenza vaccination; SMS; Text message; Vaccination; Vaccine safety; Wheeze
PMID: 29089191 DOI: 10.1016/j.vaccine.2017.10.073