tetano
Editor, Senior Moderator
Vaccine. 2019 Aug 16. pii: S0264-410X(19)31064-3. doi: 10.1016/j.vaccine.2019.08.014. [Epub ahead of print]
[h=1]A mid-term estimate of 2018/2019 vaccine effectiveness to prevent laboratory confirmed A(H1N1)pdm09 and A(H3N2) influenza cases in Sicily (Italy).[/h] Costantino C[SUP]1[/SUP], Restivo V[SUP]2[/SUP], Amodio E[SUP]2[/SUP], Colomba GME[SUP]3[/SUP], Vitale F[SUP]4[/SUP], Tramuto F[SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Via del Vespro 133, 90127, University of Palermo, Palermo, Italy. Electronic address: claudio.costantino01@unipa.it. 2 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Via del Vespro 133, 90127, University of Palermo, Palermo, Italy. 3 Regional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit - Via del Vespro 133, 90127, University Hospital "Paolo Giaccone", Palermo, Italy. 4 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Via del Vespro 133, 90127, University of Palermo, Palermo, Italy; Regional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit - Via del Vespro 133, 90127, University Hospital "Paolo Giaccone", Palermo, Italy.
[h=3]Abstract[/h] Influenza season started in Italy during the month of October 2018, approaching the epidemic peak in January 2019. This report aim to explore the mid-term virologic surveillance data of the 2018-2019 influenza season in Sicily and to estimate the effectiveness of seasonal influenza vaccine (VE) against A(H1N1)pdm09 and A(H3N2) influenza viruses. A test-negative design was used to evaluate influenza VE. In Sicily, almost all influenza infections were sustained by influenza type A viruses, of which 62.3% were A(H3N2) and 36.3% A(H1N1)pdm09. A reduction of laboratory confirmed influenza cases in Sicilian population immunized against influenza were observed. In particular, an overall significant protective values were observed for any influenza A viruses (Adj-VE = 44.0%; 95%CI: 11.2-64.7%), especially among 15-64 years old age group (Adj-VE = 59.5%; 95%CI: 0.03-83.1) and among the elderly (Adj-VE = 73.6%; 95% CI: 29.4-90.2).
Copyright ? 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza epidemic; Influenza vaccine effectiveness; Influenza viruses; Laboratory confirmed cases; Surveillance network; Test-negative design
PMID: 31427134 DOI: 10.1016/j.vaccine.2019.08.014
[h=1]A mid-term estimate of 2018/2019 vaccine effectiveness to prevent laboratory confirmed A(H1N1)pdm09 and A(H3N2) influenza cases in Sicily (Italy).[/h] Costantino C[SUP]1[/SUP], Restivo V[SUP]2[/SUP], Amodio E[SUP]2[/SUP], Colomba GME[SUP]3[/SUP], Vitale F[SUP]4[/SUP], Tramuto F[SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Via del Vespro 133, 90127, University of Palermo, Palermo, Italy. Electronic address: claudio.costantino01@unipa.it. 2 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Via del Vespro 133, 90127, University of Palermo, Palermo, Italy. 3 Regional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit - Via del Vespro 133, 90127, University Hospital "Paolo Giaccone", Palermo, Italy. 4 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Via del Vespro 133, 90127, University of Palermo, Palermo, Italy; Regional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit - Via del Vespro 133, 90127, University Hospital "Paolo Giaccone", Palermo, Italy.
[h=3]Abstract[/h] Influenza season started in Italy during the month of October 2018, approaching the epidemic peak in January 2019. This report aim to explore the mid-term virologic surveillance data of the 2018-2019 influenza season in Sicily and to estimate the effectiveness of seasonal influenza vaccine (VE) against A(H1N1)pdm09 and A(H3N2) influenza viruses. A test-negative design was used to evaluate influenza VE. In Sicily, almost all influenza infections were sustained by influenza type A viruses, of which 62.3% were A(H3N2) and 36.3% A(H1N1)pdm09. A reduction of laboratory confirmed influenza cases in Sicilian population immunized against influenza were observed. In particular, an overall significant protective values were observed for any influenza A viruses (Adj-VE = 44.0%; 95%CI: 11.2-64.7%), especially among 15-64 years old age group (Adj-VE = 59.5%; 95%CI: 0.03-83.1) and among the elderly (Adj-VE = 73.6%; 95% CI: 29.4-90.2).
Copyright ? 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza epidemic; Influenza vaccine effectiveness; Influenza viruses; Laboratory confirmed cases; Surveillance network; Test-negative design
PMID: 31427134 DOI: 10.1016/j.vaccine.2019.08.014