tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2013 Dec 30. [Epub ahead of print]
A Household-Based Study of Acute Viral Respiratory Illnesses in Andean Children.
Budge PJ, Griffin MR, Edwards KM, Williams JV, Verastegui H, Hartinger SM, Johnson M, Klemenc JM, Zhu Y, Gil AI, Lanata CF, Grijalva CG; for the RESPIRA-PERU Group.
Author information
Abstract
BACKGROUND.:
Few community studies have measured the incidence, severity, and etiology of acute respiratory illness (ARI) among children living at high-altitude in remote rural settings.
METHODS.:
We conducted active, household-based ARI surveillance among children aged <3 years in rural highland communities of San Marcos, Cajamarca, Peru from May 2009 through September 2011 (RESPIRA-PERU study). ARI (defined by fever or cough) were considered lower respiratory tract infections (LRTI) if tachypnea, wheezing, grunting, stridor, or retractions were present. Nasal swabs collected during ARI episodes were tested for respiratory viruses by real-time reverse-transcriptase polymerase chain reaction. ARI incidence was calculated using Poisson regression.
RESULTS.:
During 755.1 child-years of observation among 892 children in 58 communities, 4,475 ARI were observed, yielding an adjusted incidence of 6.2 ARI/child-year (95% CI 5.9 - 6.5). Families sought medical care for 24% of ARI, 4% were classified as LRTI, and 1% led to hospitalization. Two of five deaths among cohort children were attributed to ARI. One or more respiratory virus was detected in 67% of 3957 samples collected. Virus-specific incidence rates per 100 child-years were: rhinovirus, 236; adenovirus, 73; parainfluenza virus, 46; influenza, 37; respiratory syncytial virus, 30; and human metapneumovirus, 17. Respiratory syncytial virus, metapneumovirus, and parainfluenza virus 1-3 comprised a disproportionate share of LRTI compared to other etiologies.
CONCLUSIONS.:
In this high-altitude rural setting with low population density, ARI in young children were common, frequently severe, and associated with a number of different respiratory viruses. Effective strategies for prevention and control of these infections are needed.
PMID:
24378948
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24378948
A Household-Based Study of Acute Viral Respiratory Illnesses in Andean Children.
Budge PJ, Griffin MR, Edwards KM, Williams JV, Verastegui H, Hartinger SM, Johnson M, Klemenc JM, Zhu Y, Gil AI, Lanata CF, Grijalva CG; for the RESPIRA-PERU Group.
Author information
Abstract
BACKGROUND.:
Few community studies have measured the incidence, severity, and etiology of acute respiratory illness (ARI) among children living at high-altitude in remote rural settings.
METHODS.:
We conducted active, household-based ARI surveillance among children aged <3 years in rural highland communities of San Marcos, Cajamarca, Peru from May 2009 through September 2011 (RESPIRA-PERU study). ARI (defined by fever or cough) were considered lower respiratory tract infections (LRTI) if tachypnea, wheezing, grunting, stridor, or retractions were present. Nasal swabs collected during ARI episodes were tested for respiratory viruses by real-time reverse-transcriptase polymerase chain reaction. ARI incidence was calculated using Poisson regression.
RESULTS.:
During 755.1 child-years of observation among 892 children in 58 communities, 4,475 ARI were observed, yielding an adjusted incidence of 6.2 ARI/child-year (95% CI 5.9 - 6.5). Families sought medical care for 24% of ARI, 4% were classified as LRTI, and 1% led to hospitalization. Two of five deaths among cohort children were attributed to ARI. One or more respiratory virus was detected in 67% of 3957 samples collected. Virus-specific incidence rates per 100 child-years were: rhinovirus, 236; adenovirus, 73; parainfluenza virus, 46; influenza, 37; respiratory syncytial virus, 30; and human metapneumovirus, 17. Respiratory syncytial virus, metapneumovirus, and parainfluenza virus 1-3 comprised a disproportionate share of LRTI compared to other etiologies.
CONCLUSIONS.:
In this high-altitude rural setting with low population density, ARI in young children were common, frequently severe, and associated with a number of different respiratory viruses. Effective strategies for prevention and control of these infections are needed.
PMID:
24378948
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24378948