tetano
Editor, Senior Moderator
J Neuroimmunol. 2014 Oct 16;277(1-2):77-84. doi: 10.1016/j.jneuroim.2014.10.002. [Epub ahead of print]
A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory.
Davtyan H1, Ghochikyan A1, Hovakimyan A1, Davtyan A1, Cadagan R2, Marleau AM1, Albrecht RA2, Garc?a-Sastre A3, Agadjanyan MG4.
Author information
Abstract
Novel dual vaccine, WSN-Aβ1-10, based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ1-10 within the context of an inactivated influenza virus vaccine. These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Alzheimer's disease; Dual vaccine; Immune responses; Influenza; Memory T cells
PMID:
25455094
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25455094
A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory.
Davtyan H1, Ghochikyan A1, Hovakimyan A1, Davtyan A1, Cadagan R2, Marleau AM1, Albrecht RA2, Garc?a-Sastre A3, Agadjanyan MG4.
Author information
Abstract
Novel dual vaccine, WSN-Aβ1-10, based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ1-10 within the context of an inactivated influenza virus vaccine. These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Alzheimer's disease; Dual vaccine; Immune responses; Influenza; Memory T cells
PMID:
25455094
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25455094