tetano
Editor, Senior Moderator
Virology. 2014 May;456-457:131-8. doi: 10.1016/j.virol.2014.03.004. Epub 2014 Apr 4.
A chicken influenza virus recognizes fucosylated α2,3 sialoglycan receptors on the epithelial cells lining upper respiratory tracts of chickens.
Hiono T1, Okamatsu M1, Nishihara S2, Takase-Yoden S2, Sakoda Y1, Kida H3.
Author information
Abstract
Influenza viruses recognize sialoglycans as receptors. Although viruses isolated form chickens preferentially bind to sialic acid α2,3 galactose (SAα2,3Gal) glycans as do those of ducks, chickens were not experimentally infected with viruses isolated from ducks. A chicken influenza virus, A/chicken/Ibaraki/1/2005 (H5N2) (Ck/IBR) bound to fucose-branched SAα2,3Gal glycans, whereas the binding towards linear SAα2,3Gal glycans was weak. On the epithelial cells of the upper respiratory tracts of chickens, fucose-branched SAα2,3Gal glycans were detected, but not linear SAα2,3Gal glycans. The growth of Ck/IBR in MDCK-FUT cells, which were genetically prepared to express fucose-branched SAα2,3Gal glycans, was significantly higher than that in the parental MDCK cells. The present results indicate that fucose-branched SAα2,3Gal glycans existing on the epithelial cells lining the upper respiratory tracts of chickens are critical for recognition by Ck/IBR.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Avian influenza virus; Fucosylation; Hemagglutinin; Interspecies transmission; Receptor
PMID:
24889232
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24889232
A chicken influenza virus recognizes fucosylated α2,3 sialoglycan receptors on the epithelial cells lining upper respiratory tracts of chickens.
Hiono T1, Okamatsu M1, Nishihara S2, Takase-Yoden S2, Sakoda Y1, Kida H3.
Author information
Abstract
Influenza viruses recognize sialoglycans as receptors. Although viruses isolated form chickens preferentially bind to sialic acid α2,3 galactose (SAα2,3Gal) glycans as do those of ducks, chickens were not experimentally infected with viruses isolated from ducks. A chicken influenza virus, A/chicken/Ibaraki/1/2005 (H5N2) (Ck/IBR) bound to fucose-branched SAα2,3Gal glycans, whereas the binding towards linear SAα2,3Gal glycans was weak. On the epithelial cells of the upper respiratory tracts of chickens, fucose-branched SAα2,3Gal glycans were detected, but not linear SAα2,3Gal glycans. The growth of Ck/IBR in MDCK-FUT cells, which were genetically prepared to express fucose-branched SAα2,3Gal glycans, was significantly higher than that in the parental MDCK cells. The present results indicate that fucose-branched SAα2,3Gal glycans existing on the epithelial cells lining the upper respiratory tracts of chickens are critical for recognition by Ck/IBR.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Avian influenza virus; Fucosylation; Hemagglutinin; Interspecies transmission; Receptor
PMID:
24889232
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24889232