_|SEASONAL HUMAN INFLUENZA, ANTIVIRALS RESISTANCE, UPDATE(S)|_|MARCH 19 +|

[Giuseppe]

Re: _|SEASONAL HUMAN INFLUENZA, ANTIVIRALS RESISTANCE, UPDATE(S)|_|MARCH 19 +|

For South Africa WHO stated that ''To date, preliminary test results show that the viruses carry the specific neuraminidase mutation (H274Y) that confers oseltamivir resistance in N1, while no sign of adamantane resistance by genetic analysis have been found.''

 

[HenryN]

Re: _|SEASONAL HUMAN INFLUENZA, ANTIVIRALS RESISTANCE, UPDATE(S)|_|MARCH 19 +|

For South Africa WHO stated that ''To date, preliminary test results show that the viruses carry the specific neuraminidase mutation (H274Y) that confers oseltamivir resistance in N1, while no sign of adamantane resistance by genetic analysis have been found.''

Right now all of the h1n1 is clade 2b or 2c. 2b has na h274y while 2c has m2 s31n. Both appear to be closing in on 100% resistance the each respective gene.
H1N1 seems to be much better at adapting than its hosts.

 

[HenryN]

Re: _|SEASONAL HUMAN INFLUENZA, ANTIVIRALS RESISTANCE, UPDATE(S)|_|MARCH 19 +|

For South Africa WHO stated that ''To date, preliminary test results show that the viruses carry the specific neuraminidase mutation (H274Y) that confers oseltamivir resistance in N1, while no sign of adamantane resistance by genetic analysis have been found.''

H274Y + S31 = 2B
H274 + S31N = 2C

 

[HenryN]

Re: _|SEASONAL HUMAN INFLUENZA, ANTIVIRALS RESISTANCE, UPDATE(S)|_|MARCH 19 +|

Latest list of H274Y

gb|EU887035.1| Influenza A virus (A/South Carolina/01/2008(H1... 26.3 602
gb|EU879082.1| Influenza A virus (A/Zhejiang/Xiangshan522/200... 26.3 602
gb|EU879064.1| Influenza A virus (A/Gansu/Chenguan/1129/2007(... 26.3 602
gb|EU851986.1| Influenza A virus (A/Minnesota/01/2008(H1N1)) ... 26.3 602
gb|EU851982.1| Influenza A virus (A/Hawaii/02/2008(H1N1)) seg... 26.3 602
gb|EU851980.1| Influenza A virus (A/Hawaii/01/2008(H1N1)) seg... 26.3 602
gb|EU779650.1| Influenza A virus (A/North Carolina/02/2008(H1... 26.3 602
gb|EU779643.1| Influenza A virus (A/New Jersey/10/2008(H1N1))... 26.3 602
gb|EU779641.1| Influenza A virus (A/Memphis/03/2008(H1N1)) ne... 26.3 602
gb|EU681266.1| Influenza A virus (A/Bursa-TR/1231/2007(H1N1))... 26.3 602
gb|EU681265.1| Influenza A virus (A/Istanbul-TR/1219/2007(H1N... 26.3 602
gb|EU681264.1| Influenza A virus (A/Istanbul-TR/1198/2007(H1N... 26.3 602
gb|EU681263.1| Influenza A virus (A/Ankara-TR/170/2008(H1N1))... 26.3 602
gb|EU681262.1| Influenza A virus (A/Istanbul-TR/111/2008(H1N1... 26.3 602
gb|EU624316.1| Influenza A virus (A/England/557/2007(H1N1)) s... 26.3 602
gb|EU570806.1| Influenza A virus (A/Bursa-TR/28/2008(H1N1)) n... 26.3 602
gb|EU567014.1| Influenza A virus (A/New Jersey/06/2008(H1N1))... 26.3 602
gb|EU567011.1| Influenza A virus (A/Indiana/01/2008(H1N1)) se... 26.3 602
gb|EU567009.1| Influenza A virus (A/Arizona/13/2007(H1N1)) se... 26.3 602
gb|EU567006.1| Influenza A virus (A/Arizona/14/2007(H1N1)) se... 26.3 602
gb|EU566999.1| Influenza A virus (A/Wisconsin/01/2008(H1N1)) ... 26.3 602
gb|EU566998.1| Influenza A virus (A/Maryland/04/2007(H1N1)) s... 26.3 602
gb|EU566987.1| Influenza A virus (A/New Jersey/20/2007(H1N1))... 26.3 602
gb|EU566983.1| Influenza A virus (A/New Jersey/05/2008(H1N1))... 26.3 602
gb|EU566977.1| Influenza A virus (A/Pennsylvania/02/2008(H1N1... 26.3 602
gb|EU566968.1| Influenza A virus (A/Arizona/15/2007(H1N1)) se... 26.3 602
gb|EU516201.1| Influenza A virus (A/New Jersey/16/2007(H1N1))... 26.3 602
gb|EU516200.1| Influenza A virus (A/Illinois/10/2007(H1N1)) s... 26.3 602
gb|EU516199.1| Influenza A virus (A/Georgia/20/2006(H1N1)) se... 26.3 602
gb|EU516198.1| Influenza A virus (A/Georgia/20/2006(H1N1)) se... 26.3 602
gb|EU516197.1| Influenza A virus (A/Georgia/20/2006(H1N1)) se... 26.3 602
gb|EU516196.1| Influenza A virus (A/Arizona/03/2007(H1N1)) se... 26.3 602
gb|EU516148.1| Influenza A virus (A/New Jersey/15/2007(H1N1))... 26.3 602
gb|EU516141.1| Influenza A virus (A/Minnesota/23/2007(H1N1)) ... 26.3 602
gb|EU516125.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 26.3 602
gb|EU516123.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 26.3 602
gb|EU516112.1| Influenza A virus (A/Hawaii/21/2007(H1N1)) seg... 26.3 602
gb|EU516028.1| Influenza A virus (A/Massachusetts/05/2007(H1N... 26.3 602
gb|EU516027.1| Influenza A virus (A/Texas/31/2007(H1N1)) segm... 26.3 602
gb|CY027037.1| Influenza A virus (A/Kansas/UR06-0104/2007(H1N... 26.3 602

 

[HenryN]

Re: _|SEASONAL HUMAN INFLUENZA, ANTIVIRALS RESISTANCE, UPDATE(S)|_|MARCH 19 +|

Updated list

Zhejiang/Xiangshan522/2006
Gansu/Chenguan/1129/2007
Georgia/20/2006
Kansas/UR06-0104/2007
Massachusetts/05/2007
Minnesota/23/2007
Texas/31/2007

Arizona/03/07
Arizona/13/07
Arizona/14/07
Arizona/15/07
British Columbia/RV1585/07
Bursa-TR/1231/2007
England/557/07
Illinois/10/07
Istanbul-TR/1198/2007
Istanbul-TR/1219/2007
Maryland/04/07
New Jersey/15/07
New Jersey/16/07
New Jersey/20/07
Norway/1630/07
Norway/1651/07
Norway/1684/07
Norway/1687/07
Norway/1701/07
Norway/1731/07
Norway/1736/07
Norway/1743/07
Norway/1745/07
Norway/1747/07
Ontario/RV0131/2007
Paris/341/2007
Paris/577/2007
Paris/644/2007
Paris/749/2007
Paris/847/2007
Paris/910/2007

Ankara-TR/170/2008
Bursa-TR/28/2008
Hawaii/01/08
Hawaii/02/08
Indiana/01/08
Istanbul-TR/111/2008
Memphis/3/08
Minnesota/01/08
New Jersey/05/08
New Jersey/06/08
New Jersey/10/08
North Carolina/02/08
Paris/963/2008
Paris/1154/2008
Paris/1157/2008
Paris/1170/2008
Paris/1208/2008
Pennsylvania/02/08
South Carolina/01/2008
St Petersburg/16/2008
Trinadad/14/2008
Washington/1/08
Wisconsin/01/08
Yokohama/77/08
Yokohama/78/08
Yokohama/79/08
Hawaii/21/07
Hawaii/28/07
Lyon/1337/07
Sydney/142/07
Sydney/143/07
Sydney/144/07
Thailand/1577/2007
Aichi/76/08
Athens/41/2008
Florida/2/08
Gifu-C/17/08
Gifu-C/38/08
Kobe/27/08
Lisbon/3/08
Shimane/59/08
Tochigi/8/08
Tochigi/34/08
Tochigi/39/08
Tottori/21/08
Tottori/23/08
Tottori/28/08
Tottori/29/08
Volos/108/2008
Yamagata/68/08
Yokohama/22/08
Yokohama/30/08
Yokohama/31/08
Yokohama/34/08
Yokohama/35/08