tetano
Editor, Senior Moderator
Virus Res. 2013 Jun 1. pii: S0168-1702(13)00174-3. doi: 10.1016/j.virusres.2013.05.009. [Epub ahead of print]
2.1 Natural History of Highly Pathogenic Avian Influenza H5N1.
Sonnberg S, Webby RJ, Webster RG.
Source
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Drive MS 330, Memphis, TN, 38103 USA. Electronic address: Stephanie.sonnberg@stjude.org.
Abstract
The ecology of highly pathogenic avian influenza (HPAI) H5N1 has significantly changed from sporadic outbreaks in terrestrial poultry to persistent circulation in terrestrial and aquatic poultry and potentially in wild waterfowl. A novel genotype of HPAI H5N1 arose in 1996 in southern China and through ongoing mutation, reassortment, and natural selection, has diverged into distinct lineages and expanded into multiple reservoir hosts. The evolution of Goose/Guangdong-lineage highly pathogenic H5N1 viruses is ongoing: while stable interactions exist with some reservoir hosts, these viruses are continuing to evolve and adapt to others, and pose an un-calculable risk to sporadic hosts, including humans.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23735535
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23735535
2.1 Natural History of Highly Pathogenic Avian Influenza H5N1.
Sonnberg S, Webby RJ, Webster RG.
Source
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Drive MS 330, Memphis, TN, 38103 USA. Electronic address: Stephanie.sonnberg@stjude.org.
Abstract
The ecology of highly pathogenic avian influenza (HPAI) H5N1 has significantly changed from sporadic outbreaks in terrestrial poultry to persistent circulation in terrestrial and aquatic poultry and potentially in wild waterfowl. A novel genotype of HPAI H5N1 arose in 1996 in southern China and through ongoing mutation, reassortment, and natural selection, has diverged into distinct lineages and expanded into multiple reservoir hosts. The evolution of Goose/Guangdong-lineage highly pathogenic H5N1 viruses is ongoing: while stable interactions exist with some reservoir hosts, these viruses are continuing to evolve and adapt to others, and pose an un-calculable risk to sporadic hosts, including humans.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23735535
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23735535