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1976 vax protects

Re: 1976 vax protects

I was wondering about this situation, given that 2009 Hsw1N1 is most similar to 1976 H1N1.

From referenced article:

One of the NEJM studies also showed that many older Americans as well as recipients of the 1976 swine flu vaccine may already be protected against the new virus. In that study, researchers from the U.S. Centers for Disease Control and Prevention (CDC) report that tests of serum taken from 1976 swine flu vaccine recipients showed a strong protective immune response against today's pandemic virus. The findings may help to explain why the virus sickens children and young adults more than older people, the authors wrote. The preexisting immunity may also prime 1976 vaccinees to respond vigorously to the new pandemic vaccine.

While this appears to be a reasonable assumption, wasn't that vaccine only given in the US? If so, this idea would not explain the apparent resistance in older people in non-US countries.

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Re: 1976 vax protects

......... this idea would not explain the apparent resistance in older people in non-US countries.

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Reading further in the same article...

Adults appear protected

Since the new H1N1 virus emerged earlier this year, health officials have noted how it has disproportionately struck children and young adults and conspicuously spared older people worldwide. The disparity is most dramatic in the U.S.: 79 percent of laboratory-confirmed cases have been in people under 30 years old, whereas only two percent of cases have been in adults over 60. The U.S. median age of pandemic infections so far is 12, but somewhat higher in other countries. The median age of confirmed cases in Australia is 21, for example.

Since May, Katz, who is chief of the CDC National Influenza Division's Immunology and Pathogenesis Branch, has been testing stored serum samples to look for existing immunity to the new virus in the U.S. population. Her group's latest report shows that serum from adults born before 1930, including survivors of the 1918 pandemic, possesses antibodies that recognize and respond powerfully to the novel H1N1 virus.

With an antibody concentration of 40 or more considered protective (immunologists describe antibody responses in terms of serum dilution ratios, such as 1:40), the tests showed that 100 percent of subjects born between 1910 and 1929 mounted antibody levels of 80 or more. Only 34 percent of subjects born before 1950 mounted comparable levels, suggesting that exposure to the 1918 pandemic virus or its immediate descendents in the 1920s and 1930s conferred the strongest protection against the new flu.

The original swine flu


The CDC group also started over the summer to test 83 samples of serum drawn in 1976 from adults who received a single dose of the swine flu vaccine as well as a handful of samples from children who got the 1976 vaccine. The study found that the serum from 52 (63 percent) of the adult subjects produced antibody levels of 160 or more when exposed to the novel H1N1 virus. That number was nearly as many (59) of those whose serum demonstrated a strong response when exposed to the 1976 swine flu itself.

The NEJM report notes that a Japanese study recently reported finding protective antibody responses against the novel H1N1 virus in Japanese adults exposed to the 1918 pandemic virus, but not in subjects born after 1920. Serum from older Europeans tested by the CDC also showed lower response levels than the U.S. samples, possibly indicating a greater level of protection among Americans from the 1976 vaccine, which was given only in the U.S.

The study also confirmed previous work showing that infection with the modern seasonal H1N1 virus or exposure to seasonal vaccines in the past 20 years did not confer protection against the pandemic version of H1N1.

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Re: 1976 vax protects

Strange. I wonder how many got the 1976 vax and what kind of records still exist from that time. I know I never got the vax then. I didn't have insurance and was going to grad school. I don't remember getting the flu either.
I'm also wondering what kind of protection statins are providing older folks at least from the deadly effects of cytokine storm.
 
Re: 1976 vax protects

40 million Americans got the 1976 swine flu accination.

I can't remember if I did.

Regarding statins, maybe those with-it Australian researchers (discovered the IgG2 issue) have also compiled actual-case numbers on statin impacts.

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Re: 1976 vax protects

While this appears to be a reasonable assumption, wasn't that vaccine only given in the US? If so, this idea would not explain the apparent resistance in older people in non-US countries.

.


I'm pretty sure this vaccine was given in Canada too. My mom told a story the other day about someone telling her years ago they got it. I think she told me the man who told her that said he was paralyzed for a week or something.
 
Re: 1976 vax protects

I'm pretty sure this vaccine was given in Canada too. .........

(snipped)

But history provides other examples as well. My favourite is the great swine flu panic of 1976.

That one, too, began with fear and fanfare when, in February, a 19-year-old U.S. army recruit at Fort Dix, N.J., died after contracting a mysterious strain of swine flu.

Politicians swung into action. Faced with the spectre of another 1918-style pandemic, then-U.S. president Gerald Ford promised to inoculate every American citizen with vaccine. The Canadian government followed suit, with the proviso that ? because of the cost involved ? it would be able to inoculate only some.

Throughout 1976, the swine flu story swung between fear and farce. In August, Ontario's health minister announced the province's first swine flu death, a Goderich man. This, as it turned out, was untrue. A coroner later determined that the victim, who choked on his on vomit, had never been infected.

At Queen's Park, politicians debated who would get the scarce vaccine. All agreed on police officers and doctors. But should bank tellers be vaccinated? And what about bus drivers?

In the U.S., Nobel Prize-winning scientist Linus Pauling argued that Vitamin C would fight swine flu better than any vaccine. Here at home, the Toronto Star helpfully suggested that those inoculated against the virus should be required to give up the right to strike.

Ontario's government hemmed and hawed until, in the end, it decided to offer the vaccine to anyone who wanted it.

Alas, few did. By December, the Star reported that municipal clinics set up in Toronto to offer free flu shots were shutting down for lack of customers. Which perhaps was just as well. For when several Americans developed a mysterious and deadly paralysis after being inoculated, swine flu shots were abruptly suspended in both countries.

http://www.thestar.com/comment/columnists/article/627097
 
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