Sally Furniss
Well-known member
Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic
C?ecile Viboud ,∗, Theresa Tamb, Douglas Fleming , Andreas Handel ,
Mark A. Miller , Lone Simonsen
Abstract
There are important gaps in our current understanding of the influenza virus behavior. In particular, it remains unclear why some interpandemic
seasons are associated with unusually high mortality impact, sometimes comparable to that of pandemics. Here we compare
the epidemiological patterns of the unusually deadly 1951 influenza epidemic (A/H1N1) in England and Wales and Canada with those of
surrounding epidemic and pandemic seasons, in terms of overall mortality impact and transmissibility. Based on the statistical and mathematical
analysis of vital statistics and morbidity epidemic curves in these two countries, we show that the 1951 epidemic was associated with both
higher mortality impact and higher transmissibility than the 1957 and 1968 pandemics. Surprisingly in Liverpool, considered the ?epicenter?
of the severe 1951 epidemic, the mortality impact and transmissibility even surpassed the 1918 pandemic.
http://www.biology.emory.edu/Antia/ahandel/publications/viboud06vac.pdf
C?ecile Viboud ,∗, Theresa Tamb, Douglas Fleming , Andreas Handel ,
Mark A. Miller , Lone Simonsen
Abstract
There are important gaps in our current understanding of the influenza virus behavior. In particular, it remains unclear why some interpandemic
seasons are associated with unusually high mortality impact, sometimes comparable to that of pandemics. Here we compare
the epidemiological patterns of the unusually deadly 1951 influenza epidemic (A/H1N1) in England and Wales and Canada with those of
surrounding epidemic and pandemic seasons, in terms of overall mortality impact and transmissibility. Based on the statistical and mathematical
analysis of vital statistics and morbidity epidemic curves in these two countries, we show that the 1951 epidemic was associated with both
higher mortality impact and higher transmissibility than the 1957 and 1968 pandemics. Surprisingly in Liverpool, considered the ?epicenter?
of the severe 1951 epidemic, the mortality impact and transmissibility even surpassed the 1918 pandemic.
http://www.biology.emory.edu/Antia/ahandel/publications/viboud06vac.pdf