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CORRESPONDENCE
Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker
Published May 3, 2024
DOI: 10.1056/NEJMc2405371
snip
Viral sequences from cattle and from the worker maintained primarily avian genetic characteristics and lacked changes in the hemagglutinin gene that would affect receptor-binding specificity (e.g., binding to α2-6–linked sialic acid receptors, primarily located in the human upper respiratory tract) and transmission risk to humans. The virus identified in the worker’s specimen had a change (PB2 E627K) that has been associated with viral adaptation to mammalian hosts and detected previously in humans and other mammals infected with HPAI A(H5N1) viruses and other avian influenza A virus subtypes, including A(H7N9) and A(H9N2). No genetic markers associated with reduced susceptibility to influenza antiviral drugs approved by the Food and Drug Administration were identified. Additional results and interpretation and discussion of findings, unanswered questions, recommendations, and references are provided in the Supplementary Appendix. The hemagglutinin of the virus was found to be closely related to two existing clade 2.3.4.4b A(H5N1) candidate vaccine viruses. Because influenza A(H5N1) viruses have pandemic potential, these candidate vaccine viruses are available to manufacturers and could be used to produce vaccine if needed.
Timothy M. Uyeki, M.D., M.P.H.
Centers for Disease Control and Prevention, Atlanta, GAtmu0@cdc.gov
Scott Milton, M.D.
Cherissa Abdul Hamid, D.V.M., M.P.H.
Texas Department of State Health Services, Lubbock, TX
Cynthia Reinoso Webb, Ph.D.
Steven M. Presley, Ph.D.
Texas Tech University Bioterrorism Response Laboratory, Lubbock, TX
Varun Shetty, M.D.
Susan N. Rollo, D.V.M., Ph.D.
Diana L. Martinez, Ph.D., M.P.H.
Saroj Rai, Ph.D., M.P.H.
Emilio R. Gonzales, M.P.H.
Texas Department of State Health Services, Austin, TX
Krista L. Kniss, M.P.H.
Yunho Jang, Ph.D.
Julia C. Frederick, Ph.D.
Juan A. De La Cruz, M.S.
Jimma Liddell, M.S.
Han Di, Ph.D.
Marie K. Kirby, Ph.D.
John R. Barnes, Ph.D.
C. Todd Davis, Ph.D.
Centers for Disease Control and Prevention, Atlanta, GA
...
https://www.nejm.org/doi/full/10.1056/NEJMc2405371
Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker
Published May 3, 2024
DOI: 10.1056/NEJMc2405371
snip
Viral sequences from cattle and from the worker maintained primarily avian genetic characteristics and lacked changes in the hemagglutinin gene that would affect receptor-binding specificity (e.g., binding to α2-6–linked sialic acid receptors, primarily located in the human upper respiratory tract) and transmission risk to humans. The virus identified in the worker’s specimen had a change (PB2 E627K) that has been associated with viral adaptation to mammalian hosts and detected previously in humans and other mammals infected with HPAI A(H5N1) viruses and other avian influenza A virus subtypes, including A(H7N9) and A(H9N2). No genetic markers associated with reduced susceptibility to influenza antiviral drugs approved by the Food and Drug Administration were identified. Additional results and interpretation and discussion of findings, unanswered questions, recommendations, and references are provided in the Supplementary Appendix. The hemagglutinin of the virus was found to be closely related to two existing clade 2.3.4.4b A(H5N1) candidate vaccine viruses. Because influenza A(H5N1) viruses have pandemic potential, these candidate vaccine viruses are available to manufacturers and could be used to produce vaccine if needed.
Timothy M. Uyeki, M.D., M.P.H.
Centers for Disease Control and Prevention, Atlanta, GAtmu0@cdc.gov
Scott Milton, M.D.
Cherissa Abdul Hamid, D.V.M., M.P.H.
Texas Department of State Health Services, Lubbock, TX
Cynthia Reinoso Webb, Ph.D.
Steven M. Presley, Ph.D.
Texas Tech University Bioterrorism Response Laboratory, Lubbock, TX
Varun Shetty, M.D.
Susan N. Rollo, D.V.M., Ph.D.
Diana L. Martinez, Ph.D., M.P.H.
Saroj Rai, Ph.D., M.P.H.
Emilio R. Gonzales, M.P.H.
Texas Department of State Health Services, Austin, TX
Krista L. Kniss, M.P.H.
Yunho Jang, Ph.D.
Julia C. Frederick, Ph.D.
Juan A. De La Cruz, M.S.
Jimma Liddell, M.S.
Han Di, Ph.D.
Marie K. Kirby, Ph.D.
John R. Barnes, Ph.D.
C. Todd Davis, Ph.D.
Centers for Disease Control and Prevention, Atlanta, GA
...
https://www.nejm.org/doi/full/10.1056/NEJMc2405371
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