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Emerg Infect Dis . Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b

tetano

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2023 Jul;29(7):1492-1495.
doi: 10.3201/eid2907.230296.
Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b

Annika Graaf, Ronja Piesche, Julia Sehl-Ewert, Christian Grund, Anne Pohlmann, Martin Beer, Timm Harder
Free article Abstract

We found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resistance of pigs to clade 2.3.4.4b infection.

Keywords: H5N1; HPAIV; goose/Guangdong; mammal; panzootic; pigs; zoonosis.

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Treyfish said:
Wonder how the cow strains will interact with swine
Click to expand...

I think what it boils down to is maybe we should be careful not to dismiss the H5N1 2.3.4.4b strain as a pandemic threat simply because it does not infect swine very well. There may be many other avenues to the development of a human pandemic strain besides reassortment in pigs. Best to keep one's mind open to that possibility. It seems to be capable of infecting every other mammal species I can think of.
 
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