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Sci Rep
. 2023 Sep 4;13(1):14529.
doi: 10.1038/s41598-023-41684-3. Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study
Hiromasa Yamamoto # 1 , Shinya Tanaka # 1 , Daisuke Kasugai 2 , Miho Shimizu 3 , Yohei Tsuchikawa 1 , Yuto Hori 1 , Yuki Fugane 1 , Takayuki Inoue 1 , Motoki Nagaya 1 , Norihito Omote 4 , Michiko Higashi 5 , Takanori Yamamoto 5 , Naruhiro Jingushi 5 , Atsushi Numaguchi 5 , Yukari Goto 5 , Yoshihiro Nishida 1 6
Affiliations
This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.
. 2023 Sep 4;13(1):14529.
doi: 10.1038/s41598-023-41684-3. Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study
Hiromasa Yamamoto # 1 , Shinya Tanaka # 1 , Daisuke Kasugai 2 , Miho Shimizu 3 , Yohei Tsuchikawa 1 , Yuto Hori 1 , Yuki Fugane 1 , Takayuki Inoue 1 , Motoki Nagaya 1 , Norihito Omote 4 , Michiko Higashi 5 , Takanori Yamamoto 5 , Naruhiro Jingushi 5 , Atsushi Numaguchi 5 , Yukari Goto 5 , Yoshihiro Nishida 1 6
Affiliations
- PMID: 37666912
- DOI: 10.1038/s41598-023-41684-3
This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.