Int J Infect Dis . Benefits of plasma exchange on mortality in patients with COVID-19: a systematic review and meta-analysis

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Int J Infect Dis


. 2022 Jun 13;S1201-9712(22)00348-4.
doi: 10.1016/j.ijid.2022.06.014. Online ahead of print.
Benefits of plasma exchange on mortality in patients with COVID-19: a systematic review and meta-analysis


Jinlv Qin ¹ , Guizuo Wang ² , Dong Han ³



Affiliations

• PMID: 35709964
• DOI: 10.1016/j.ijid.2022.06.014

Abstract

Background: The Coronavirus disease-2019 (COVID-19) pandemic continues, and the death toll continues to surge. This systematic review and meta-analysis aimed to determine the efficacy of therapeutic plasma exchange (TPE) on mortality in patients with COVID-19.
Methods: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Controlled clinical trials on treatment of COVID-19 with TPE, compared with standard of care (SOC), were reviewed. Studies were pooled to risk ratios (RRs) and weighted mean differences (WMDs), with 95% confidence intervals (CIs).
Results: Six trials (enrolling 343 participants) met the inclusion criteria. Therapeutic plasma exchange showed significant effect on mortality (RR 0.41, 95% CI 0.24 to 0.69; P = 0.0008).
Conclusions: TPE significantly reduced mortality in hospitalized patients with moderate-to-critical COVID-19. Plasma exchange therapy should be considered for COVID-19 patients.

Keywords: COVID-19; Mortality; meta-analysis; plasma exchange.