Adv Exp Med Biol . Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network

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Adv Exp Med Biol


. 2021;1352:125-147.
doi: 10.1007/978-3-030-85109-5_8.
Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network


Mudassar Ali ^{# 1} , Jyotirmoy Rajurkar ^{# 1} , Priyanka Majumder ¹ , Mainak Pratim Jha ¹ , Rajasri Sarkar ¹ , Koyeli Mapa ²



Affiliations

• PMID: 35132598
• DOI: 10.1007/978-3-030-85109-5_8

Abstract

Introduction: The recent outbreak of coronavirus infection by SARS-CoV-2 that started from the Wuhan Province of China in 2019 has spread to most parts of the world infecting millions of people. Although the case fatality rate of SARS-CoV-2 infection is less than the previous epidemics by other closely related coronaviruses, due to its high infectivity, the total number of SARS-CoV-2 infection-associated disease, called Covid-19, is a matter of global concern. Despite drastic preventive measures, the number of Covid-19 cases are steadily increasing, and the future course of this pandemic is highly unpredictable. The most concerning fact about Covid-19 is the absence of specific and effective preventive or therapeutic agents against the disease. Finding an immediate intervention against Covid-19 is the need of the hour. In this chapter, we have discussed the role of different branches of the cellular proteostasis network, represented by Hsp70-Hsp40 chaperone system, Ubiquitin-Proteasome System (UPS), autophagy, and endoplasmic reticulum-Unfolded Protein Response (ER-UPR) pathway in the pathogenesis of coronavirus infections and in the host antiviral defense mechanisms.
Results: Based on scientific literature, we present that pharmacological manipulation of proteostasis network can alter the fate of coronavirus infections and may help to prevent the resulting pathologies like Covid-19.

Keywords: Autophagy; Covid-19; ER-UPR; Hsp70; Molecular chaperones; Proteostasis; SARS-CoV-2.