Pharmacol Rep . In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis

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Pharmacol Rep


. 2021 Feb 20.
doi: 10.1007/s43440-021-00233-3. Online ahead of print.
In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis


Hikmat Permana ¹ , Ian Huang ² , Aga Purwiga ² , Nuraini Yasmin Kusumawardhani ³ , Teddy Arnold Sihite ³ , Erwan Martanto ³ , Rudi Wisaksana ⁴ , Nanny Natalia M Soetedjo ⁵



Affiliations

• PMID: 33608850
• DOI: 10.1007/s43440-021-00233-3

Abstract

Background and aims: The idea of treating COVID-19 with statins is biologically plausible, although it is still controversial. The systematic review and meta-analysis aimed to address the association between the use of statins and risk of mortality in patients with COVID-19.
Methods: Several electronic databases, including PubMed, SCOPUS, EuropePMC, and the Cochrane Central Register of Controlled Trials, with relevant keywords up to 11 November 2020, were used to perform a systematic literature search. This study included research papers containing samples of adult COVID-19 patients who had data on statin use and recorded mortality as their outcome of interest. Risk estimates of mortality in statin users versus non-statin users were pooled across studies using inverse-variance weighted DerSimonian-Laird random-effect models.
Results: Thirteen studies with a total of 52,122 patients were included in the final qualitative and quantitative analysis. Eight studies reported in-hospital use of statins; meanwhile, the remaining studies reported pre-admission use of statins. In-hospital use of statin was associated with a reduced risk of mortality (RR 0.54, 95% CI 0.50-0.58, p < 0.00001; I²: 0%, p = 0.87), while pre-admission use of statin was not associated with mortality (RR 1.18, 95% CI 0.79-1.77, p = 0.415; I²: 68.6%, p = 0.013). The funnel plot for the association between the use of statins and mortality were asymmetrical.
Conclusion: This meta-analysis showed that in-hospital use of statins was associated with a reduced risk of mortality in patients with COVID-19.

Keywords: COVID-19; In-hospital; Mortality; Pre-admission; SARS-CoV-2; Statins.