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Chembiochem
. 2020 Oct 8.
doi: 10.1002/cbic.202000595. Online ahead of print.
Tackling SARS-CoV-2 Infections using Remdesivir and Favipiravir as Therapeutic Options
Sreekanth Reddy Obireddy 1 , Lai Wing-Fu 2
Affiliations
- PMID: 33031623
- DOI: 10.1002/cbic.202000595
Abstract
The outbreak of pandemic COVID-19 causes severe damage to the human world, including infections, deaths, and economic disruptions. The world has focused on developing treatment and controlling measures against COVID-19. Currently, there is no specific approved therapy or medication for the disease, therefore this pandemic situation demonstrates the immediate need for wide-ranging antiviral countermeasures to SARS-CoV-2 and future coronaviruses. This article provides an overview of the structure, virology, symptoms, life cycle, and routes of transmission of SARS-CoV-2. The therapeutic effect of two drugs that are regarded to show therapeutic potential [i.e., remdesivir (RDV) and favipiravir (FPV)] against COVID-19 are discussed based on the current published data. This review can serve as a reference for future studies.
Keywords: COVID-19; Favipiravir; Remdesivir; Routes of transmission; Virology.