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Use of the PiCCO system in critically ill patients with septic shock and acute respiratory distress syndrome: a study protocol for a randomized controlled trial
Zhongheng Zhang, Xiao Xu, Min Yao, Huilan Chen, Hongying Ni and Haozhe Fan
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Trials 2013, 14:32 doi:10.1186/1745-6215-14-32
Published: 1 February 2013
Abstract (provisional)
Background
Hemodynamic monitoring is very important in critically ill patients with shock oracute respiratory distress syndrome(ARDS). The PiCCO (Pulse index Contour Continuous Cardiac Output, Pulsion Medical Systems, Germany) system has been developed and used in critical care settings for several years. However, its impact on clinical outcomes remains unknown.
Methods
The study is a randomized controlled multi-center trial. A total of 708 patients with ARDS, septic shock or both will be included from January 2012 to January 2014. Subjects will be randomized to receive PiCCO monitoring or not. Our primary end point is 30-day mortality, and secondaryoutcome measures include ICU length of stay, days on mechanical ventilation, days of vasoactive agent support, ICU-free survival days during a 30-day period, mechanical-ventilation-free survival days during a 30-day period, and maximum SOFA score during the first 7 days.
Discussion
We investigate whether the use of PiCCO monitoring will improve patient outcomes in critically ill patients with ARDS or septic shock. This will provide additional data on hemodynamic monitoring and help clinicians to make decisions on the use of PiCCO.
Trial registration: www.clinicaltrials.gov NCT01526382
full text
Zhongheng Zhang, Xiao Xu, Min Yao, Huilan Chen, Hongying Ni and Haozhe Fan
For all author emails, please log on.
Trials 2013, 14:32 doi:10.1186/1745-6215-14-32
Published: 1 February 2013
Abstract (provisional)
Background
Hemodynamic monitoring is very important in critically ill patients with shock oracute respiratory distress syndrome(ARDS). The PiCCO (Pulse index Contour Continuous Cardiac Output, Pulsion Medical Systems, Germany) system has been developed and used in critical care settings for several years. However, its impact on clinical outcomes remains unknown.
Methods
The study is a randomized controlled multi-center trial. A total of 708 patients with ARDS, septic shock or both will be included from January 2012 to January 2014. Subjects will be randomized to receive PiCCO monitoring or not. Our primary end point is 30-day mortality, and secondaryoutcome measures include ICU length of stay, days on mechanical ventilation, days of vasoactive agent support, ICU-free survival days during a 30-day period, mechanical-ventilation-free survival days during a 30-day period, and maximum SOFA score during the first 7 days.
Discussion
We investigate whether the use of PiCCO monitoring will improve patient outcomes in critically ill patients with ARDS or septic shock. This will provide additional data on hemodynamic monitoring and help clinicians to make decisions on the use of PiCCO.
Trial registration: www.clinicaltrials.gov NCT01526382
full text
