Medicine (Baltimore) . Adult influenza epidemic is associated with out-of-hospital cardiac arrest: From the All-Japan Utstein Registry, a prospective, nationwide, population-based, observational registry

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Medicine (Baltimore)


. 2022 Jun 17;101(24):e29535.
doi: 10.1097/MD.0000000000029535.
Adult influenza epidemic is associated with out-of-hospital cardiac arrest: From the All-Japan Utstein Registry, a prospective, nationwide, population-based, observational registry


Yasunori Suematsu ¹ , Takashi Kuwano ¹ , Motoki Yamashita ¹ , Hiroyuki Tsutsui ² , Naoki Sato ³ , Takanori Ikeda ⁴ , Ken Nagao ⁵ , Naohiro Yonemoto ⁶ , Yoshio Tahara ⁷ , Keijiro Saku ¹ , Shin-Ichiro Miura ^{1 8} , Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Group



Affiliations

• PMID: 35713463
• DOI: 10.1097/MD.0000000000029535

Abstract

It has been reported that influenza infection is associated with out-of-hospital cardiac arrest of cardiac origin (OHCA-CA). However, the association between OHCA-CA and influenza epidemics in adults has not been well investigated.We analyzed data from the All-Japan Utstein Registry, a prospective, nationwide, population-based, observational study, regarding OHCA-CA cases and the Infectious Diseases Weekly Report for influenza cases: 17,710 OHCA-CA cases and 764,808 influenza cases were recorded between 2005 and 2015 in Fukuoka, Japan. The weekly average number of OHCA-CA cases was positively associated with the number of patients with influenza infection (r = 0.70, P < .0001). To eliminate the effects of season and age, we investigated only adults in winter. The weekly number of OHCA-CA cases was positively associated with the number of patients with influenza infection in weeks when there was a high frequency of influenza infection in adults (r = 0.36, P = .006), but not in weeks with a medium (r = 0.26, P = .05) or low frequency of influenza infection (r = 0.003, P = 1.0). In weeks during which there was a high frequency of influenza infection, the weekly number of OHCA-CA cases was positively associated with the number of influenza infections in males (r = 0.37, P = .006), but not females (r = 0.18, P = .2).The number of OHCA-CA cases was positively associated with the number of influenza infections in adult males during weeks in which there was a high frequency of influenza infections. To help prevent OHCA-CA in males, it might be beneficial to announce influenza epidemics specifically in adults, in addition to all ages.