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Proc Natl Acad Sci U S A. 2014 Dec 22. pii: 201405216. [Epub ahead of print]
Avian influenza H5N1 viral and bird migration networks in Asia.
Tian H1, Zhou S2, Dong L3, Van Boeckel TP4, Cui Y5, Wu Y5, Cazelles B6, Huang S1, Yang R5, Grenfell BT7, Xu B8.
Author information
Abstract
The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.
KEYWORDS:
HPAI H5N1; bird migration; network; satellite tracking; viral migration
PMID: 25535385 [PubMed - as supplied by publisher]
Avian influenza H5N1 viral and bird migration networks in Asia.
Tian H1, Zhou S2, Dong L3, Van Boeckel TP4, Cui Y5, Wu Y5, Cazelles B6, Huang S1, Yang R5, Grenfell BT7, Xu B8.
Author information
Abstract
The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.
KEYWORDS:
HPAI H5N1; bird migration; network; satellite tracking; viral migration
PMID: 25535385 [PubMed - as supplied by publisher]
