Open Forum Infect Dis . Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

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Open Forum Infect Dis


. 2022 Apr 27;9(6):ofac171.
doi: 10.1093/ofid/ofac171. eCollection 2022 Jun.
Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies


Jane C Figueiredo ¹ , Fred R Hirsch ² , Lawrence H Kushi ³ , Wendy N Nembhard ⁴ , James M Crawford ⁵ , Nicholas Mantis ⁶ , Laurel Finster ¹ , Noah M Merin ⁷ , Akil Merchant ⁷ , Karen L Reckamp ¹ , Gil Y Melmed ⁸ , Jonathan Braun ⁸ , Dermot McGovern ⁸ , Samir Parekh ² , Douglas A Corley ³ , Namvar Zohoori ⁴ , Benjamin C Amick ⁴ , Ruofei Du ⁴ , Peter K Gregersen ⁵ , Betty Diamond ⁵ , Emanuela Taioli ² , Carlos Sariol ⁹ , Ana Espino ⁹ , Daniela Weiskopf ¹⁰ , Alba Gifoni ¹⁰ , James Brien ¹¹ , William Hanege ¹² , Marc Lipsitch ¹² , David A Zidar ¹³ , Ann Scheck McAlearney ¹⁴ , Ania Wajnberg ¹⁵ , Joshua LaBaer ¹⁶ , E Yvonne Lewis ¹⁷ , Raquel A Binder ¹⁸ , Ann M Moormann ¹⁸ , Catherine Forconi ¹⁸ , Sarah Forrester ¹⁹ , Jennifer Batista ¹⁹ , John Schieffelin ²⁰ , Dongjoo Kim ²¹ , Giulia Biancon ²² , Jennifer VanOudenhove ²² , Stephanie Halene ²² , Rong Fan ²¹ , Dan H Barouch ²³ , Galit Alter ²⁴ , Swetha Pinninti ²⁵ , Suresh B Boppana ²⁵ , Sunil K Pati ²⁵ , Misty Latting ²⁵ , Andrew H Karaba ²⁶ , John Roback ²⁷ , Rafick Sekaly ²⁷ , Andrew Neish ²⁷ , Ahnalee M Brincks ²⁸ , Douglas A Granger ²⁹ , Amy B Karger ³⁰ , Bharat Thyagarajan ³¹ , Stefani N Thomas ³⁰ , Sabra L Klein ³¹ , Andrea L Cox ²⁶ , Todd Lucas ³² , Debra Furr-Holden ³² , Kent Key ³² , Nicole Jones ³² , Jens Wrammerr ³³ , Mehul Suthar ³³ , Serre Yu Wong ³⁴ , Natalie M Bowman ³⁵ , Viviana Simon ³⁶ , Lynne D Richardson ³⁷ , Russell McBride ³⁸ , Florian Krammer ³⁶ , Meenakshi Rana ³⁸ , Joshua Kennedy ³⁹ , Karl Boehme ⁴⁰ , Craig Forrest ⁴⁰ , Steve W Granger ⁴¹ , Christopher D Heaney ⁴² , Maria Knight Lapinski ⁴³ , Shannon Wallet ⁴⁴ , Ralph S Baric ⁴⁵ , Luca Schifanella ⁴⁶ , Marcos Lopez ⁴⁷ , Soledad Fernández ⁴⁸ , Eben Kenah ⁴⁹ , Ashish R Panchal ⁵⁰ , William J Britt ⁵¹ , Iñaki Sanz ⁵² , Madhav Dhodapkar ⁵² , Rafi Ahmed ⁵³ , Luther A Bartelt ³⁵ , Alena J Markmann ³⁵ , Jessica T Lin ³⁵ , Robert S Hagan ³⁵ , Matthew C Wolfgang ⁵⁴ , Jacek Skarbinski ³



Affiliations

• PMID: 35765315
• PMCID: PMC9129196
• DOI: 10.1093/ofid/ofac171

Abstract

Background: Global efforts are needed to elucidate the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the underlying cause of coronavirus disease 2019 (COVID-19), including seroprevalence, risk factors, and long-term sequelae, as well as immune responses after vaccination across populations and the social dimensions of prevention and treatment strategies.
Methods: In the United States, the National Cancer Institute in partnership with the National Institute of Allergy and Infectious Diseases, established the SARS-CoV-2 Serological Sciences Network (SeroNet) as the nation's largest coordinated effort to study coronavirus disease 2019. The network comprises multidisciplinary researchers bridging gaps and fostering collaborations among immunologists, epidemiologists, virologists, clinicians and clinical laboratories, social and behavioral scientists, policymakers, data scientists, and community members. In total, 49 institutions form the SeroNet consortium to study individuals with cancer, autoimmune disease, inflammatory bowel diseases, cardiovascular diseases, human immunodeficiency virus, transplant recipients, as well as otherwise healthy pregnant women, children, college students, and high-risk occupational workers (including healthcare workers and first responders).
Results: Several studies focus on underrepresented populations, including ethnic minorities and rural communities. To support integrative data analyses across SeroNet studies, efforts are underway to define common data elements for standardized serology measurements, cellular and molecular assays, self-reported data, treatment, and clinical outcomes.
Conclusions: In this paper, we discuss the overarching framework for SeroNet epidemiology studies, critical research questions under investigation, and data accessibility for the worldwide scientific community. Lessons learned will help inform preparedness and responsiveness to future emerging diseases.

Keywords: COVID-19; SARS-CoV-2; SeroNet; cohort; epidemiology; serosurveillance.