Oxf Med Case Reports . COVID-19-positivity in a heart transplant recipient-antibody-mediated rejection or SARS-CoV-2-associated cardiac injury?

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Oxf Med Case Reports


. 2022 Jan 24;2022(1):omab143.
doi: 10.1093/omcr/omab143. eCollection 2022 Jan.
COVID-19-positivity in a heart transplant recipient-antibody-mediated rejection or SARS-CoV-2-associated cardiac injury?


Paul J Hanson ¹ , Felicia Liu-Fei ¹ , Chi Lai ² , Mustafa Toma ³ , Bruce M McManus ⁴



Affiliations

• PMID: 35083057
• PMCID: PMC8787635
• DOI: 10.1093/omcr/omab143

Abstract

Through the ongoing and heightening coronavirus disease 2019 (COVID-19) pandemic, the heart has been implicated as a central target of injury associated with significantly increased morbidity and mortality. Correspondingly, heart transplant recipients are a vulnerable population for which insufficient research has been conducted. Pathologic antibody-mediated rejection (pAMR) of cardiac allografts shares many characteristics with COVID-19-associated cardiac injury. In this case study, we investigate a 57-year-old female who contracted COVID-19 11 days postheart transplant and was observed to have pAMR while positive for laboratory-confirmed COVID-19, resulting in a diagnostic conundrum.