Int J Hematol . Clinical characteristics and risk factors associated with nosocomial COVID-19 infection in patients with hematological disorders in Japan

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Int J Hematol


. 2021 Jun 21.
doi: 10.1007/s12185-021-03172-0. Online ahead of print.
Clinical characteristics and risk factors associated with nosocomial COVID-19 infection in patients with hematological disorders in Japan


Shin Ohara ¹ , Takayuki Fujii ² , Shiro Ide ² , Tomoyuki Uchida ² , Morihiro Inoue ² , Masao Hagaihara ²



Affiliations

• PMID: 34152562
• DOI: 10.1007/s12185-021-03172-0

Abstract

Patients with cancer are considered at high risk of acquiring coronavirus disease (COVID-19). To identify patients who are likely to be diagnosed with severe COVID-19, we analyzed the risk factors for mortality in patients admitted to the hematology department at our institute. The mortality rate of all patients was as high as 62% (21 of the 34 patients), and most of these patients had malignant malignancies. Patients before an achievement of remission had a 10.8-fold higher risk of death than those in remission. The group receiving chemotherapy with steroids had a shorter survival time and had an 8.3-fold higher risk of death than that receiving chemotherapy without steroids. During the COVID-19 pandemic, it is necessary to carefully monitor or follow-up patients with active diseases and patients receiving steroid-containing chemotherapy.

Keywords: COVID-19; Chemotherapy; Hematological disorders; Nosocomial infection.