Pathol Res Pract . Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function

[tetano]

Pathol Res Pract


. 2022 Jan 29;231:153782.
doi: 10.1016/j.prp.2022.153782. Online ahead of print.
Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function


Ehsan Ahmadi ¹ , Zahra Bagherpour ² , Elmira Zarei ³ , Azadeh Omidkhoda ⁴



Affiliations

• PMID: 35121363
• DOI: 10.1016/j.prp.2022.153782

Abstract

The novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 outbreak, spread rapidly and infected more than 140 million people with more than three million victims worldwide. The SARS-CoV-2 causes destructive changes in the immunological and hematological system of the host. These alterations appear to play a critical role in disease pathology and the emerging of clinical manifestations. In this review, we aimed to discuss the effect of COVID-19 on the count, function and morphology of immune and blood cells and the role of these changes in the pathophysiology of the disease. Knowledge of these changes may help with better management and treatment of COVID-19 patients.

Keywords: Blood platelets; Erythrocytes; Granulocytes; Immunity; Monocytes; SARS-COV-2.