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J Neuroimmunol. 2015 May 15;282:97-103. doi: 10.1016/j.jneuroim.2015.04.001. Epub 2015 Apr 2.
Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection.
Sanders RD1, Grover V2, Goulding J3, Godlee A4, Gurney S5, Snelgrove R6, Ma D7, Singh S8, Maze M9, Hussell T10.
Author information
Abstract
Benzodiazepines increase vulnerability to infection through α1 subunit dependent Υ-amino-butyric-type-A (GABAA) signalling. Immune cell expression of GABAA receptors and the effect of diazepam on influenza infection was investigated. In patients with pneumonia, α1 GABAA subunits were expressed on alveolar macrophages and blood monocytes. In mice, influenza induced dynamic changes in immune cell GABAA subunit expression: α1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells. Following influenza viral infection, diazepam delayed weight loss on day 3 but later increased weight loss. Viral load was unaffected but increased bacterial superinfection was noted on day 10.
Copyright ? 2015. Published by Elsevier B.V.
KEYWORDS:
Benzodiazepine; GABA; Immune; Infection
PMID: 25903735 [PubMed - in process]
Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection.
Sanders RD1, Grover V2, Goulding J3, Godlee A4, Gurney S5, Snelgrove R6, Ma D7, Singh S8, Maze M9, Hussell T10.
Author information
Abstract
Benzodiazepines increase vulnerability to infection through α1 subunit dependent Υ-amino-butyric-type-A (GABAA) signalling. Immune cell expression of GABAA receptors and the effect of diazepam on influenza infection was investigated. In patients with pneumonia, α1 GABAA subunits were expressed on alveolar macrophages and blood monocytes. In mice, influenza induced dynamic changes in immune cell GABAA subunit expression: α1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells. Following influenza viral infection, diazepam delayed weight loss on day 3 but later increased weight loss. Viral load was unaffected but increased bacterial superinfection was noted on day 10.
Copyright ? 2015. Published by Elsevier B.V.
KEYWORDS:
Benzodiazepine; GABA; Immune; Infection
PMID: 25903735 [PubMed - in process]