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J Clin Med
. 2024 Nov 28;13(23):7242.
doi: 10.3390/jcm13237242. High-Density Lipoprotein Predicts Intrahospital Mortality in Influenza
Matthias Wolfgang Heinzl 1 2 , Markus Freudenthaler 1 3 , Paul Fellinger 4 , Lisa Kolenchery 1 2 , Michael Resl 1 2 , Carmen Klammer 1 2 , Florian Obendorf 1 , Lukas Schinagl 1 , Thomas Berger 1 , Margot Egger 3 5 , Benjamin Dieplinger 3 , Martin Clodi 1 2 3
Affiliations
Background: Although it is known that high-density lipoprotein (HDL) exerts important anti-inflammatory effects and that low HDL plasma concentrations represent a negative prognostic marker in bacterial infections and sepsis, not much is known about possible implications of HDL in acute viral infections such as influenza. Methods: We performed a retrospective, single-centre analysis of influenza patients hospitalised during the 2018/19 and 2019/20 influenza seasons and analysed the impact of HDL concentrations on inflammation and mortality. Results: 199 influenza patients (173 male patients) were admitted during the 2018/19 and 2019/20 influenza seasons with a mortality rate of 4.5%. HDL was significantly lower in deceased patients (median HDL 21 (IQR 19-25) vs. 35 (IQR 28-44) mg/dL; p = 0.005). Low HDL correlated with increased inflammation and HDL was an independent negative predictor regarding mortality after correction for age and the number of comorbidities both overall (OR = 0.890; p = 0.008) and in male patients only (OR = 0.891; p = 0.009). Conclusions: Low HDL upon hospital admission is associated with increased inflammation and is an independent predictor for increased mortality in male patients with influenza A.
Keywords: HDL; acute viral infection; anti-inflammatory; influenza; lipid scavenging; lipoproteins.
. 2024 Nov 28;13(23):7242.
doi: 10.3390/jcm13237242. High-Density Lipoprotein Predicts Intrahospital Mortality in Influenza
Matthias Wolfgang Heinzl 1 2 , Markus Freudenthaler 1 3 , Paul Fellinger 4 , Lisa Kolenchery 1 2 , Michael Resl 1 2 , Carmen Klammer 1 2 , Florian Obendorf 1 , Lukas Schinagl 1 , Thomas Berger 1 , Margot Egger 3 5 , Benjamin Dieplinger 3 , Martin Clodi 1 2 3
Affiliations
- PMID: 39685701
- DOI: 10.3390/jcm13237242
Background: Although it is known that high-density lipoprotein (HDL) exerts important anti-inflammatory effects and that low HDL plasma concentrations represent a negative prognostic marker in bacterial infections and sepsis, not much is known about possible implications of HDL in acute viral infections such as influenza. Methods: We performed a retrospective, single-centre analysis of influenza patients hospitalised during the 2018/19 and 2019/20 influenza seasons and analysed the impact of HDL concentrations on inflammation and mortality. Results: 199 influenza patients (173 male patients) were admitted during the 2018/19 and 2019/20 influenza seasons with a mortality rate of 4.5%. HDL was significantly lower in deceased patients (median HDL 21 (IQR 19-25) vs. 35 (IQR 28-44) mg/dL; p = 0.005). Low HDL correlated with increased inflammation and HDL was an independent negative predictor regarding mortality after correction for age and the number of comorbidities both overall (OR = 0.890; p = 0.008) and in male patients only (OR = 0.891; p = 0.009). Conclusions: Low HDL upon hospital admission is associated with increased inflammation and is an independent predictor for increased mortality in male patients with influenza A.
Keywords: HDL; acute viral infection; anti-inflammatory; influenza; lipid scavenging; lipoproteins.