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Weekly U.S. Influenza Surveillance Report
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Updated February 9, 2024
Key Updates for Week 5, ending February 3, 2024
Seasonal influenza activity remains elevated nationally with increases in some parts of the country. Viruses
Clinical Lab 15.8%
(Trend
)
positive for influenza
this week
Public Health Lab
The most frequently reported influenza viruses this week were influenza A(H1N1)pdm09.
Virus Characterization
Genetic and antigenic characterization and antiviral susceptibility are summarized in this report. Illness
Outpatient Respiratory Illness 4.4%
(Trend)
of visits to a health care provider this week were for respiratory illness
(above baseline).
Outpatient Respiratory Illness: Activity Map
This week 11 jurisdictions experienced moderate activity and 25 jurisdictions experienced high or very high activity.
FluSurv-NET 51.5 per 100,000
cumulative hospitalization rate.
NHSN Hospitalizations 11,073 (Trend
)
patients admitted to hospitals with influenza this week.
NCHS Mortality 0.8%
(Trend)
of deaths attributed to influenza this week.
Pediatric Deaths 8
influenza-associated deaths were reported
this week for a total of 74 deaths this season.
All data are preliminary and may change as more reports are received.
Directional arrows indicate changes between the current week and the previous week. Additional information on the arrows can be found at the bottom of this page.
A description of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component is available on the surveillance methods page.
Additional information on the current and previous influenza seasons for each surveillance component are available on FluView Interactive.
Key Points
Nationally, the percentage of respiratory specimens testing positive for influenza in clinical laboratories remained stable (change of <0.5 percentage points) compared to the previous week, but trends varied by region. Regions 3, 5, and 7 reported an increase in percent positivity, Region 1 remained stable and regions 2, 4, 6, 8, 9, and 10 reported a decrease. The regions with the highest percent positivity were regions 6 (29.5%), 7 (20.7%), 8 (18.4%), and 5 (18.1%). Since Week 40, influenza A(H1N1)pdm09 has been the predominant virus circulating in all regions. However, the distribution of circulating viruses varies by region, particularly in regions 5 and 7 where influenza B activity has been increasing. For regional and state level data and age group distribution, please visit FluView Interactive. Viruses known to be associated with recent receipt of live attenuated influenza vaccine (LAIV) or found upon further testing to be a vaccine virus are not included, as they are not circulating influenza viruses. Clinical Laboratories
The results of tests performed by clinical laboratories nationwide are summarized below. Data from clinical laboratories (the percentage of specimens tested that are positive for influenza virus) are used to monitor whether influenza activity is increasing or decreasing.
View Chart Data | View Full Screen Public Health Laboratories
The results of tests performed by public health laboratories nationwide are summarized below. Data from public health laboratories are used to monitor the proportion of circulating influenza viruses that belong to each influenza subtype/lineage.
View Chart Data | View Full Screen
Additional virologic surveillance information for current and past seasons:
Surveillance Methods | FluView Interactive: National, Regional, and State Data or Age Data Influenza Virus Characterization
CDC performs genetic and antigenic characterization of U.S. viruses submitted from state and local public health laboratories according to the Right Size Roadmap submission guidance. These data are used to compare how similar the currently circulating influenza viruses are to the reference viruses representing viruses contained in the current influenza vaccines. The data are also used to monitor evolutionary changes that continually occur in influenza viruses circulating in humans. CDC also tests susceptibility of circulating influenza viruses to antiviral medications including the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) and the PA endonuclease inhibitor baloxavir.
CDC has genetically characterized 1,725 influenza viruses collected since October 1, 2023.
CDC antigenically characterizes influenza viruses by hemagglutination inhibition (HI) (H1N1pdm09, H3N2, B/Victoria, and B/Yamagata viruses) or neutralization-based HINT (H3N2 viruses) using antisera that ferrets make after being infected with reference viruses representing the 2023-2024 Northern Hemisphere recommended cell or recombinant-based vaccine viruses. Antigenic differences between viruses are determined by comparing how well the antibodies made against the vaccine reference viruses recognize the circulating viruses that have been grown in cell culture. Ferret antisera are useful because antibodies raised against a particular virus can often recognize small changes in the surface proteins of other viruses. In HI assays, viruses with similar antigenic properties have antibody titer differences of less than or equal to 4-fold when compared to the reference (vaccine) virus. In HINT, viruses with similar antigenic properties have antibody neutralization titer differences of less than or equal to 8-fold. Viruses selected for antigenic characterization are a subset representing the genetic changes in the surface proteins seen in genetically characterized viruses.
Influenza A Viruses
Influenza B Viruses
Assessment of Virus Susceptibility to Antiviral Medications
CDC assesses susceptibility of influenza viruses to the antiviral medications including the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) and the PA endonuclease inhibitor baloxavir using next generation sequence analysis supplemented by laboratory assays. Information about antiviral susceptibility test methods can be found at U.S. Influenza Surveillance: Purpose and Methods | CDC.
Viruses collected in the U.S. since October 01, 2023, were tested for antiviral susceptibility as follows:
One A(H1N1)pdm09 virus had NA-H275Y amino acid substitution and showed highly reduced inhibition by oseltamivir and peramivir. One (H1N1)pdm09 virus had NA-S247N and NA-I223V amino acid substitutions and showed reduced inhibition by oseltamivir. One A(H3N2) virus had PA-I38T amino acid substitution and showed reduced susceptibility to baloxavir.
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A(H1N1)pdm09 and influenza A(H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, use of these antivirals for treatment and prevention of influenza A virus infection is not recommended and data from adamantane resistance testing are not presented. Outpatient Respiratory Illness Surveillance
The U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) monitors outpatient visits for respiratory illness referred to as influenza-like illness [ILI (fever plus cough or sore throat)], not laboratory-confirmed influenza and will therefore capture respiratory illness visits due to infection with pathogens that can present with similar symptoms, including influenza viruses, SARS-CoV-2, and RSV. It is important to evaluate syndromic surveillance data, including that from ILINet, in the context of other sources of surveillance data to obtain a more complete and accurate picture of influenza, SARS-CoV-2, and other respiratory virus activity. CDC is providing integrated information about COVID-19, influenza, and RSV activity on a website that is updated weekly. Information about other respiratory virus activity can be found on CDC’s National Respiratory and Enteric Virus Surveillance System (NREVSS) website. Outpatient Respiratory Illness Visits
Nationwide, during Week 5, 4.4% of patient visits reported through ILINet were due to respiratory illness that included fever plus a cough or sore throat, also referred to as ILI. This has remained stable (change of ≤ 0.1 percentage points) compared to Week 4 and has remained above the national baseline of 2.9% since Week 44. The percentage of visits for ILI increased in regions 2, 5, 6, 7, and 10, decreased in regions 4 and 9, and remained stable in regions 1, 3, and 8 in Week 5 compared to Week 4. All regions remain above their region-specific baselines this week. Multiple respiratory viruses are co-circulating, and the relative contribution of influenza virus infection to ILI varies by location.
Outpatient Respiratory Illness Visits by Age Group
About 70% of ILINet participants provide both the number of patient visits for respiratory illness and the total number of patient visits for the week broken out by age group. Data from this subset of providers are used to calculate the percentages of patient visits for respiratory illness by age group.
The percentage of visits for respiratory illness reported in ILINet increased in the 5-24 years age group (change of > 0.1 percentage points), decreased in the 25-49 years and 50-64 years age groups, and remained stable in the 0-4 and 65+ years age groups during Week 5 compared to Week 4.
Outpatient Respiratory Illness Activity Map
Data collected in ILINet are used to produce a measure of ILI activity* by state/jurisdiction and Core Based Statistical Areas (CBSA).
*Data collected in ILINet may disproportionally represent certain populations within a jurisdiction or CBSA, and therefore, may not accurately depict the full picture of influenza activity for the entire jurisdiction or CBSA. Differences in the data presented here by CDC and independently by some health departments likely represent differing levels of data completeness with data presented by the health department likely being the more complete.
Additional information about medically attended visits for ILI for current and past seasons:
Surveillance Methods | FluView Interactive: National, Regional, and State Data or ILI Activity Map Hospitalization Surveillance
FluSurv-NET
The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in 14 states and represents approximately 9% of the U.S. population. FluSurv-NET hospitalization data are preliminary. As data are received each week, prior case counts and rates are updated accordingly.
A total of 15,743 laboratory-confirmed influenza-associated hospitalizations were reported by FluSurv-NET sites between October 1, 2023, and February 03, 2024. The weekly hospitalization rate observed in Week 5 was 2.7 per 100,000 population. The weekly hospitalization rate observed during Week 52 is the third highest peak weekly rate observed during all seasons going back to 2010-2011 following the 2014-2015 and 2017-2018 seasons. The overall cumulative hospitalization rate was 51.5 per 100,000 population. This cumulative hospitalization rate is the third highest cumulative hospitalization rate when compared against previous end-of-season rates for Week 5, following the 2017-2018 season (59.9) and 2022-2023 season (59.2). Cumulative in-season hospitalization rates observed in Week 5 from 2010-2011 through 2021-2022 ranged from 0.6 to 44.1.
When examining rates by age, the highest cumulative hospitalization rate per 100,000 population was among adults aged 65 years and older (138.7), followed by adults aged 50-64 years (63.5) and children aged 0-4 years (54.0). When examining age-adjusted rates by race and ethnicity, the highest rate of hospitalization per 100,000 population was among non-Hispanic Black persons (95.7), followed by Hispanic persons (48.9), non-Hispanic American Indian or Alaska Native persons (68.5), non-Hispanic White persons (34.6), and non-Hispanic Asian/Pacific Islander persons (29.1).
Among 15,743 hospitalizations, 13,854 (88.0%) were associated with influenza A virus, 1,747 (11.1%) with influenza B virus, 29 (0.2%) with influenza A virus and influenza B virus co-infection, and 113 (0.7%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 2,279 (75.8%) were A(H1N1) pdm09 and 727 (24.2%) were A(H3N2). Based on preliminary data, of the 785 laboratory-confirmed influenza-associated hospitalizations with more complete data admitted through November 2023, 4.0% (95% CI: 2.3%-5.7%) also tested positive for SARS-CoV-2.
Among 613 hospitalized adults with information on underlying medical conditions, 94.4% had at least one reported underlying medical condition, the most commonly reported were hypertension, cardiovascular disease, metabolic disorder, and obesity. Among 910 hospitalized women of childbearing age (15-49 years) with information on pregnancy status, 18.2% were pregnant. Among 409 hospitalized children with information on underlying medical conditions, 70.4% had at least one reported underlying medical condition; the most commonly reported was asthma, followed by obesity and neurologic disease.
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In this figure, cumulative rates for all seasons prior to the 2023-2024 season reflect end-of-season rates. For the 2023-2024 season, rates for recent hospitals admissions are subject to reporting delays. As hospitalization data are reviewed each week, prior case counts and rates are updated accordingly.
View Full Screen
In this figure, weekly rates for all seasons prior to the 2023-24 season reflect end-of-season rates. For the 2023-24 season, rates for recent hospital admissions are subject to reporting delays and are shown as a dashed line for the current season. As hospitalization data are received each week, prior case counts and rates are updated accordingly.
Additional FluSurv-NET hospitalization surveillance information for current and past seasons and additional age groups:
Surveillance Methods |FluView Interactive: Rates by Age, Sex, and Race/Ethnicity or Data on Patient Characteristics | RESP-NET Interactive National Healthcare Safety Network (NHSN) Hospitalization Surveillance
Hospitals report to NHSN the weekly number of patients admitted with laboratory-confirmed influenza. During Week 5, 11,073 patients with laboratory-confirmed influenza were admitted to a hospital. The number of patients admitted to a hospital with laboratory-confirmed influenza for Week 5 decreased compared to Week 4 (change of >5%) nationally. The number of hospitalizations increased in regions 1, 5, and 7, remained stable in Region 6, and decreased in regions 2, 3, 4, 8, 9, and 10 this week compared to Week 4.
View Chart Data | View Full Screen
Additional NHSN Hospitalization Surveillance information:
Surveillance Methods | Additional Data | FluView Interactive Mortality Surveillance
National Center for Health Statistics (NCHS) Mortality Surveillance
Based on NCHS mortality surveillance data available on February 8, 2024, 0.8% of the deaths that occurred during the week ending February 3, 2024 (Week 5), were due to influenza. This percentage decreased (≥ 0.1 percentage point change) compared to Week 4. The data presented are preliminary and may change as more data are received and processed.
Additional pneumonia, influenza and COVID-19 mortality surveillance information for current and past seasons:
Surveillance Methods | FluView Interactive Influenza-Associated Pediatric Mortality
Eight influenza-associated pediatric deaths occurring during the 2023-2024 season were reported to CDC during Week 5. The deaths occurred between Week 51 of 2023 (the week ending December 23, 2023) and Week 5 of 2024 (the week ending February 3, 2024). Seven deaths were associated with influenza A viruses. Four of the influenza A viruses had subtyping performed; three were A(H1N1) viruses and one was an A(H3) virus. One death was associated with influenza B virus with no lineage determined.
A total of 74 influenza-associated pediatric deaths occurring during the 2023-2024 season have been reported to CDC.
Additional pediatric mortality surveillance information for current and past seasons:
Surveillance Methods | FluView Interactive Trend Indicators
Increasing:
Decreasing:
Stable: Indicators Status by System
Clinical Labs: Up or down arrows indicate a change of greater than or equal to 0.5 percentage points in the percent of specimens positive for influenza compared to the previous week.
Outpatient Respiratory Illness (ILINet): Up or down arrows indicate a change of greater than 0.1 percentage points in the percent of visits due to respiratory illness (ILI) compared to the previous week.
NHSN Hospitalizations: Up or down arrows indicate change of greater than or equal to 5% of the number of patients admitted with laboratory-confirmed influenza compared to the previous week.
NCHS Mortality: Up or down arrows indicate change of greater than 0.1 percentage points of the percent of deaths due to influenza compared to the previous week. Reference Footnotes
1U.S. Influenza Surveillance: Purpose and Methods (2023 Oct). Centers for Disease Control and Prevention. https://www.cdc.gov/flu/weekly/overview.htm#ILINet.
2Grohskopf LA, Blanton LH, Ferdinands JM, Chung JR, Broder KR, Talbot HK. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2023–24 Influenza Season. MMWR Recomm Rep 2023;72(No. RR-2):1–25. DOI: http://dx.doi.org/10.15585/mmwr.rr7202a1
3Influenza Antiviral Medications: Summary for Clinicians (2023 Sept). Centers for Disease Control and Prevention. https://www.cdc.gov/flu/professional...clinicians.htm.
Additional National and International Influenza Surveillance Information
FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics.
National Institute for Occupational Safety and Health: Monthly surveillance data on the prevalence of health-related workplace absenteeism among full-time workers in the United States are available from NIOSH.
U.S. State and local influenza surveillance: Select a jurisdiction below to access the latest local influenza information.
https://www.cdc.gov/flu/weekly/index.htm
Updated February 9, 2024
Key Updates for Week 5, ending February 3, 2024
Seasonal influenza activity remains elevated nationally with increases in some parts of the country. Viruses
Clinical Lab 15.8%
(Trend
)positive for influenza
this week
Public Health Lab
The most frequently reported influenza viruses this week were influenza A(H1N1)pdm09.
Virus Characterization
Genetic and antigenic characterization and antiviral susceptibility are summarized in this report. Illness
Outpatient Respiratory Illness 4.4%
(Trend
)of visits to a health care provider this week were for respiratory illness
(above baseline).
Outpatient Respiratory Illness: Activity Map
This week 11 jurisdictions experienced moderate activity and 25 jurisdictions experienced high or very high activity.
FluSurv-NET 51.5 per 100,000
cumulative hospitalization rate.
NHSN Hospitalizations 11,073 (Trend
)patients admitted to hospitals with influenza this week.
NCHS Mortality 0.8%
(Trend
)of deaths attributed to influenza this week.
Pediatric Deaths 8
influenza-associated deaths were reported
this week for a total of 74 deaths this season.
All data are preliminary and may change as more reports are received.
Directional arrows indicate changes between the current week and the previous week. Additional information on the arrows can be found at the bottom of this page.
A description of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component is available on the surveillance methods page.
Additional information on the current and previous influenza seasons for each surveillance component are available on FluView Interactive.
Key Points
- Seasonal influenza activity remains elevated nationally with increases in some parts of the country, particularly regions 5 and 7.
- Nationally, percent positivity for influenza overall remained stable. However, percent positivity for influenza A decreased slightly and percent positivity for influenza B increased slightly, driven primarily by activity in regions 5 and 7.
- Outpatient respiratory illness has been above baseline1 nationally since November and is above baseline in all 10 HHS regions.
- The number of weekly flu hospital admissions decreased slightly compared to last week.
- During Week 5, of the 819 viruses reported by public health laboratories, 623 (76.1%) were influenza A and 196 (23.9%) were influenza B. Of the 400 influenza A viruses subtyped during Week 5, 270 (67.5%) were influenza A(H1N1) and 130 (32.5%) were A(H3N2).
- Eight influenza-associated pediatric deaths were reported during Week 5, bringing the 2023-2024 season total to 74 pediatric deaths.
- CDC estimates that there have been at least 22 million illnesses, 250,000 hospitalizations, and 15,000 deaths from flu so far this season.
- CDC recommends that everyone 6 months and older get an annual flu vaccine as long as influenza viruses are spreading.2 Vaccination can still provide benefit this season.
- There also are prescription flu antiviral drugs that can treat flu illness; those should be started as early as possible and are especially important for higher risk patients.3
- Flu viruses are among several viruses contributing to respiratory disease activity. CDC is providing updated, integrated information about COVID-19, flu, and RSV activity on a weekly basis.
Nationally, the percentage of respiratory specimens testing positive for influenza in clinical laboratories remained stable (change of <0.5 percentage points) compared to the previous week, but trends varied by region. Regions 3, 5, and 7 reported an increase in percent positivity, Region 1 remained stable and regions 2, 4, 6, 8, 9, and 10 reported a decrease. The regions with the highest percent positivity were regions 6 (29.5%), 7 (20.7%), 8 (18.4%), and 5 (18.1%). Since Week 40, influenza A(H1N1)pdm09 has been the predominant virus circulating in all regions. However, the distribution of circulating viruses varies by region, particularly in regions 5 and 7 where influenza B activity has been increasing. For regional and state level data and age group distribution, please visit FluView Interactive. Viruses known to be associated with recent receipt of live attenuated influenza vaccine (LAIV) or found upon further testing to be a vaccine virus are not included, as they are not circulating influenza viruses. Clinical Laboratories
The results of tests performed by clinical laboratories nationwide are summarized below. Data from clinical laboratories (the percentage of specimens tested that are positive for influenza virus) are used to monitor whether influenza activity is increasing or decreasing.
| No. of specimens tested | 96,379 | 1,868,917 |
| No. of positive specimens (%) | 15,192 (15.8%) | 191,459 (10.2%) |
| Positive specimens by type | ||
| Influenza A | 10,453 (68.8%) | 150,153 (78.4%) |
| Influenza B | 4,739 (31.2%) | 41,296 (21.6%) |
View Chart Data | View Full Screen Public Health Laboratories
The results of tests performed by public health laboratories nationwide are summarized below. Data from public health laboratories are used to monitor the proportion of circulating influenza viruses that belong to each influenza subtype/lineage.
| No. of specimens tested | 2,790 | 68,366 |
| No. of positive specimens | 819 | 21,004 |
| Positive specimens by type/subtype | ||
| Influenza A | 623 (76.1%) | 17,303 (82.4%) |
| Subtyping Performed | 400 (64.2%) | 13,955 (80.7%) |
| (H1N1)pdm09 | 270 (67.5%) | 10,972 (78.6%) |
| H3N2 | 130 (32.5%) | 2,983 (21.4%) |
| H3N2v | 0 (0.0%) | 0 (0.0%) |
| Subtyping not performed | 223 (35.8%) | 3,348 (19.3%) |
| Influenza B | 196 (23.9%) | 3,701 (17.6%) |
| Lineage testing performed | 99 (50.5%) | 2,949 (79.7%) |
| Yamagata lineage | 0 (0.0%) | 0 (0.0%) |
| Victoria lineage | 99 (100%) | 2,949 (100%) |
| Lineage not performed | 97 (49.5%) | 752 (20.3%) |
View Chart Data | View Full Screen
Additional virologic surveillance information for current and past seasons:
Surveillance Methods | FluView Interactive: National, Regional, and State Data or Age Data Influenza Virus Characterization
CDC performs genetic and antigenic characterization of U.S. viruses submitted from state and local public health laboratories according to the Right Size Roadmap submission guidance. These data are used to compare how similar the currently circulating influenza viruses are to the reference viruses representing viruses contained in the current influenza vaccines. The data are also used to monitor evolutionary changes that continually occur in influenza viruses circulating in humans. CDC also tests susceptibility of circulating influenza viruses to antiviral medications including the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) and the PA endonuclease inhibitor baloxavir.
CDC has genetically characterized 1,725 influenza viruses collected since October 1, 2023.
| A/H1 | 815 | ||||
| 6B.1A.5a | 815 (100%) | 2a | 225 (27.6%) | ||
| 2a.1 | 590 (72.4%) | ||||
| A/H3 | 458 | ||||
| 3C.2a1b.2a | 458 (100%) | 2a.1b | 1 (0.2%) | ||
| 2a.3a | 1 (0.2%) | ||||
| 2a.3a.1 | 455 (99.3%) | ||||
| 2b | 1 (0.2%) | ||||
| B/Victoria | 452 | ||||
| V1A | 452 (100%) | 3a.2 | 452 (100%) | ||
| B/Yamagata | 0 | ||||
| Y3 | 0 | Y3 | 0 (0%) |
Influenza A Viruses
- A (H1N1)pdm09: 107 A(H1N1)pdm09 viruses were antigenically characterized by HI, and all were well-recognized (reacting at titers that were within 4-fold of the homologous virus titer) by ferret antisera to cell-grown A/Wisconsin/67/2022-like reference viruses representing the A(H1N1)pdm09 component for the cell- and recombinant-based influenza vaccines.
- A (H3N2): 110 A(H3N2) viruses were antigenically characterized by HI or HINT, and all were well-recognized (reacting at titers that were within 4-fold of the homologous virus titer in HI or reacting at titers that were less than or equal to 8-fold of the homologous virus in HINT) by ferret antisera to cell-grown A/Darwin/6/2021-like reference viruses representing the A(H3N2) component for the cell- and recombinant-based influenza vaccines.
Influenza B Viruses
- B/Victoria: Sixty-one influenza B/Victoria-lineage virus were antigenically characterized by HI, and all were well-recognized (reacting at titers that were within 4-fold of the homologous virus titer) by ferret antisera to cell-grown B/Austria/1359417/2021-like reference viruses representing the B/Victoria component for the cell- and recombinant-based influenza vaccines.
- B/Yamagata: No influenza B/Yamagata-lineage viruses were available for antigenic characterization.
Assessment of Virus Susceptibility to Antiviral Medications
CDC assesses susceptibility of influenza viruses to the antiviral medications including the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) and the PA endonuclease inhibitor baloxavir using next generation sequence analysis supplemented by laboratory assays. Information about antiviral susceptibility test methods can be found at U.S. Influenza Surveillance: Purpose and Methods | CDC.
Viruses collected in the U.S. since October 01, 2023, were tested for antiviral susceptibility as follows:
| Neuraminidase Inhibitors | Oseltamivir | Viruses Tested | 1723 | 816 | 460 | 447 |
| Reduced Inhibition | 1 (0.1%) | 1 (0.1%) | 0 (0.0%) | 0 (0.0%) | ||
| Highly Reduced Inhibition | 1 (0.1%) | 1 (0.1%) | 0 (0.0%) | 0 (0.0%) | ||
| Peramivir | Viruses Tested | 1723 | 816 | 460 | 447 | |
| Reduced Inhibition | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| Highly Reduced Inhibition | 1 (0.1%) | 1 (0.1%) | 0 (0.0%) | 0 (0.0%) | ||
| Zanamivir | Viruses Tested | 1723 | 816 | 460 | 447 | |
| Reduced Inhibition | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| Highly Reduced Inhibition | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| PA Cap-Dependent Endonuclease Inhibitor | Baloxavir | Viruses Tested | 1682 | 793 | 450 | 439 |
| Decreased Susceptibility | 1 (0.1%) | 0 (0.0%) | 1 (0.2%) | 0 (0.0%) |
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A(H1N1)pdm09 and influenza A(H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, use of these antivirals for treatment and prevention of influenza A virus infection is not recommended and data from adamantane resistance testing are not presented. Outpatient Respiratory Illness Surveillance
The U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) monitors outpatient visits for respiratory illness referred to as influenza-like illness [ILI (fever plus cough or sore throat)], not laboratory-confirmed influenza and will therefore capture respiratory illness visits due to infection with pathogens that can present with similar symptoms, including influenza viruses, SARS-CoV-2, and RSV. It is important to evaluate syndromic surveillance data, including that from ILINet, in the context of other sources of surveillance data to obtain a more complete and accurate picture of influenza, SARS-CoV-2, and other respiratory virus activity. CDC is providing integrated information about COVID-19, influenza, and RSV activity on a website that is updated weekly. Information about other respiratory virus activity can be found on CDC’s National Respiratory and Enteric Virus Surveillance System (NREVSS) website. Outpatient Respiratory Illness Visits
Nationwide, during Week 5, 4.4% of patient visits reported through ILINet were due to respiratory illness that included fever plus a cough or sore throat, also referred to as ILI. This has remained stable (change of ≤ 0.1 percentage points) compared to Week 4 and has remained above the national baseline of 2.9% since Week 44. The percentage of visits for ILI increased in regions 2, 5, 6, 7, and 10, decreased in regions 4 and 9, and remained stable in regions 1, 3, and 8 in Week 5 compared to Week 4. All regions remain above their region-specific baselines this week. Multiple respiratory viruses are co-circulating, and the relative contribution of influenza virus infection to ILI varies by location.
Outpatient Respiratory Illness Visits by Age Group
About 70% of ILINet participants provide both the number of patient visits for respiratory illness and the total number of patient visits for the week broken out by age group. Data from this subset of providers are used to calculate the percentages of patient visits for respiratory illness by age group.
The percentage of visits for respiratory illness reported in ILINet increased in the 5-24 years age group (change of > 0.1 percentage points), decreased in the 25-49 years and 50-64 years age groups, and remained stable in the 0-4 and 65+ years age groups during Week 5 compared to Week 4.
Outpatient Respiratory Illness Activity Map
Data collected in ILINet are used to produce a measure of ILI activity* by state/jurisdiction and Core Based Statistical Areas (CBSA).
| Week 5 (Week ending Feb. 3, 2024) |
Week 4 (Week ending Jan. 27, 2024) |
Week 5 (Week ending Feb. 3, 2024) |
Week 4 (Week ending Jan. 27, 2024) |
|
| Very High | 6 | 5 | 14 | 17 |
| High | 19 | 14 | 97 | 93 |
| Moderate | 11 | 13 | 123 | 112 |
| Low | 10 | 9 | 181 | 182 |
| Minimal | 8 | 14 | 279 | 306 |
| Insufficient Data | 1 | 0 | 235 | 219 |
*Data collected in ILINet may disproportionally represent certain populations within a jurisdiction or CBSA, and therefore, may not accurately depict the full picture of influenza activity for the entire jurisdiction or CBSA. Differences in the data presented here by CDC and independently by some health departments likely represent differing levels of data completeness with data presented by the health department likely being the more complete.
Additional information about medically attended visits for ILI for current and past seasons:
Surveillance Methods | FluView Interactive: National, Regional, and State Data or ILI Activity Map Hospitalization Surveillance
FluSurv-NET
The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in 14 states and represents approximately 9% of the U.S. population. FluSurv-NET hospitalization data are preliminary. As data are received each week, prior case counts and rates are updated accordingly.
A total of 15,743 laboratory-confirmed influenza-associated hospitalizations were reported by FluSurv-NET sites between October 1, 2023, and February 03, 2024. The weekly hospitalization rate observed in Week 5 was 2.7 per 100,000 population. The weekly hospitalization rate observed during Week 52 is the third highest peak weekly rate observed during all seasons going back to 2010-2011 following the 2014-2015 and 2017-2018 seasons. The overall cumulative hospitalization rate was 51.5 per 100,000 population. This cumulative hospitalization rate is the third highest cumulative hospitalization rate when compared against previous end-of-season rates for Week 5, following the 2017-2018 season (59.9) and 2022-2023 season (59.2). Cumulative in-season hospitalization rates observed in Week 5 from 2010-2011 through 2021-2022 ranged from 0.6 to 44.1.
When examining rates by age, the highest cumulative hospitalization rate per 100,000 population was among adults aged 65 years and older (138.7), followed by adults aged 50-64 years (63.5) and children aged 0-4 years (54.0). When examining age-adjusted rates by race and ethnicity, the highest rate of hospitalization per 100,000 population was among non-Hispanic Black persons (95.7), followed by Hispanic persons (48.9), non-Hispanic American Indian or Alaska Native persons (68.5), non-Hispanic White persons (34.6), and non-Hispanic Asian/Pacific Islander persons (29.1).
Among 15,743 hospitalizations, 13,854 (88.0%) were associated with influenza A virus, 1,747 (11.1%) with influenza B virus, 29 (0.2%) with influenza A virus and influenza B virus co-infection, and 113 (0.7%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 2,279 (75.8%) were A(H1N1) pdm09 and 727 (24.2%) were A(H3N2). Based on preliminary data, of the 785 laboratory-confirmed influenza-associated hospitalizations with more complete data admitted through November 2023, 4.0% (95% CI: 2.3%-5.7%) also tested positive for SARS-CoV-2.
Among 613 hospitalized adults with information on underlying medical conditions, 94.4% had at least one reported underlying medical condition, the most commonly reported were hypertension, cardiovascular disease, metabolic disorder, and obesity. Among 910 hospitalized women of childbearing age (15-49 years) with information on pregnancy status, 18.2% were pregnant. Among 409 hospitalized children with information on underlying medical conditions, 70.4% had at least one reported underlying medical condition; the most commonly reported was asthma, followed by obesity and neurologic disease.
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In this figure, cumulative rates for all seasons prior to the 2023-2024 season reflect end-of-season rates. For the 2023-2024 season, rates for recent hospitals admissions are subject to reporting delays. As hospitalization data are reviewed each week, prior case counts and rates are updated accordingly.
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In this figure, weekly rates for all seasons prior to the 2023-24 season reflect end-of-season rates. For the 2023-24 season, rates for recent hospital admissions are subject to reporting delays and are shown as a dashed line for the current season. As hospitalization data are received each week, prior case counts and rates are updated accordingly.
Additional FluSurv-NET hospitalization surveillance information for current and past seasons and additional age groups:
Surveillance Methods |FluView Interactive: Rates by Age, Sex, and Race/Ethnicity or Data on Patient Characteristics | RESP-NET Interactive National Healthcare Safety Network (NHSN) Hospitalization Surveillance
Hospitals report to NHSN the weekly number of patients admitted with laboratory-confirmed influenza. During Week 5, 11,073 patients with laboratory-confirmed influenza were admitted to a hospital. The number of patients admitted to a hospital with laboratory-confirmed influenza for Week 5 decreased compared to Week 4 (change of >5%) nationally. The number of hospitalizations increased in regions 1, 5, and 7, remained stable in Region 6, and decreased in regions 2, 3, 4, 8, 9, and 10 this week compared to Week 4.
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Additional NHSN Hospitalization Surveillance information:
Surveillance Methods | Additional Data | FluView Interactive Mortality Surveillance
National Center for Health Statistics (NCHS) Mortality Surveillance
Based on NCHS mortality surveillance data available on February 8, 2024, 0.8% of the deaths that occurred during the week ending February 3, 2024 (Week 5), were due to influenza. This percentage decreased (≥ 0.1 percentage point change) compared to Week 4. The data presented are preliminary and may change as more data are received and processed.
Additional pneumonia, influenza and COVID-19 mortality surveillance information for current and past seasons:
Surveillance Methods | FluView Interactive Influenza-Associated Pediatric Mortality
Eight influenza-associated pediatric deaths occurring during the 2023-2024 season were reported to CDC during Week 5. The deaths occurred between Week 51 of 2023 (the week ending December 23, 2023) and Week 5 of 2024 (the week ending February 3, 2024). Seven deaths were associated with influenza A viruses. Four of the influenza A viruses had subtyping performed; three were A(H1N1) viruses and one was an A(H3) virus. One death was associated with influenza B virus with no lineage determined.
A total of 74 influenza-associated pediatric deaths occurring during the 2023-2024 season have been reported to CDC.
Additional pediatric mortality surveillance information for current and past seasons:
Surveillance Methods | FluView Interactive Trend Indicators
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Stable:
Indicators Status by SystemClinical Labs: Up or down arrows indicate a change of greater than or equal to 0.5 percentage points in the percent of specimens positive for influenza compared to the previous week.
Outpatient Respiratory Illness (ILINet): Up or down arrows indicate a change of greater than 0.1 percentage points in the percent of visits due to respiratory illness (ILI) compared to the previous week.
NHSN Hospitalizations: Up or down arrows indicate change of greater than or equal to 5% of the number of patients admitted with laboratory-confirmed influenza compared to the previous week.
NCHS Mortality: Up or down arrows indicate change of greater than 0.1 percentage points of the percent of deaths due to influenza compared to the previous week. Reference Footnotes
1U.S. Influenza Surveillance: Purpose and Methods (2023 Oct). Centers for Disease Control and Prevention. https://www.cdc.gov/flu/weekly/overview.htm#ILINet.
2Grohskopf LA, Blanton LH, Ferdinands JM, Chung JR, Broder KR, Talbot HK. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2023–24 Influenza Season. MMWR Recomm Rep 2023;72(No. RR-2):1–25. DOI: http://dx.doi.org/10.15585/mmwr.rr7202a1
3Influenza Antiviral Medications: Summary for Clinicians (2023 Sept). Centers for Disease Control and Prevention. https://www.cdc.gov/flu/professional...clinicians.htm.
Additional National and International Influenza Surveillance Information
FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics.
National Institute for Occupational Safety and Health: Monthly surveillance data on the prevalence of health-related workplace absenteeism among full-time workers in the United States are available from NIOSH.
U.S. State and local influenza surveillance: Select a jurisdiction below to access the latest local influenza information.
https://www.cdc.gov/flu/weekly/index.htm
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