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JAMA Open: Excess All-Cause Mortality in China After Ending the Zero COVID Policy - EID Journal Estimate

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  • JAMA Open: Excess All-Cause Mortality in China After Ending the Zero COVID Policy - EID Journal Estimate

    JAMA Open: Excess All-Cause Mortality in China After Ending the Zero COVID Policy




    #17,636



    In China, `bad news' - like the number of pigs lost to ASF, the number of human infections with avian flu (H5N6, H5N1, H3N8, etc.), when and where COVID first appeared, or China's true GDP - are treated as issues of national security, and are either hidden, heavily redacted, or made up out of whole cloth by the CCP.

    During the first 3 years of the COVID pandemic, China - with a population of 1.4 billion - only admitted to 5242 deaths from the virus. Less than half of what the city of Hong Kong (pop. 7 million) had reported.


    While they attributed this remarkable success to their `Zero-COVID' policies, few outside observers put much stock in those numbers. By last December, the wheels had come off, the public was near revolt, and China was forced to abandon `Zero-COVID'.

    As a form of damage control, China created very narrow definitions for what qualified as a `COVID-related death' (see China: NHC - Only Respiratory Failure Due to COVID to Be Counted As A COVID Death).


    Five days later (Dec. 25th, 2023) China simply stopped reporting COVID numbers altogether (see China: NHC Will No Longer Release Daily COVID Figures). Since then we've seen some outside attempts to quantify the impact of COVID on China last winter, but the full story will probably never be truly known.

    Yesterday, a new investigative report was published by JAMA Open, which estimates 1.87 million excess deaths in China in the two months following the collapse of Zero COVID. I've only reproduced the Abstract below, so follow the link to read the report in its entirety.

    I'll have a postscript when you return.

    Original Investigation
    Infectious Diseases
    August 24, 2023
    Excess All-Cause Mortality in China After Ending the Zero COVID Policy
    Hong Xiao, PhD1; Zhicheng Wang, PhD2; Fang Liu, MD2; et alJoseph M. Unger, PhD, MS1 Author Affiliations Article Information JAMA Netw Open. 2023;6(8):e2330877. doi:10.1001/jamanetworkopen.2023.30877
    Key Points

    Question Was the sudden end of China’s zero COVID policy associated with an increase in population all-cause mortality?

    Findings In this cohort study across all regions in mainland China, an estimated 1.87 million excess deaths occurred among individuals 30 years and older during the first 2 months after the end of China’s zero COVID policy. Excess deaths predominantly occurred among older individuals and were observed across all provinces in mainland China, with the exception of Tibet.

    Meaning These findings suggest that the sudden lifting of the zero COVID policy in China was associated with significant increases in all-cause mortality.

    Abstract

    Importance In China, the implementation of stringent mitigation measures kept COVID-19 incidence and excess mortality low during the first years of the pandemic. However, China’s decision to end its dynamic zero COVID policy (a proactive strategy that deploys mass testing and strict quarantine measures to stamp out any outbreak before it can spread) in December 2022 resulted in a surge in COVID-19 incidence and hospitalizations. Despite worldwide attention given to this event, the actual impact of this sudden shift in policy on population mortality has not been empirically estimated.

    Objective To assess the association of the sudden shift in China’s dynamic zero COVID policy with mortality using empirical and syndromic surveillance data.

    Design, Setting, and Participants This cohort study analyzed published obituary data from 3 universities in China (2 in Beijing and 1 in Heilongjiang) and search engine data from the Baidu index (BI; weighted frequency of unique searches for a given keyword relative to the total search volume on the Baidu search engine) in each region of China from January 1, 2016, to January 31, 2023. Using an interrupted time-series design, analyses estimated the relative change in mortality among individuals 30 years and older in the universities and the change in BI for mortality-related terms in each region of China from December 2022 to January 2023. Analysis revealed a strong correlation between Baidu searches for mortality-related keywords and actual mortality burden. Using this correlation, the relative increase in mortality in Beijing and Heilongjiang was extrapolated to the rest of China, and region-specific excess mortality was calculated by multiplying the proportional increase in mortality by the number of expected deaths. Data analysis was performed from February 10, 2023, to March 5, 2023.

    Exposure The end to the dynamic zero COVID policy in December 2022 in China.

    Main Outcomes and Measures Monthly all-cause mortality by region.

    Results An estimated 1.87 million (95% CI, 0.71 million-4.43 million; 1.33 per 1000 population) excess deaths occurred among individuals 30 years and older in China during the first 2 months after the end of the zero COVID policy. Excess deaths predominantly occurred among older individuals and were observed across all provinces in mainland China except Tibet.

    Conclusions and Relevance In this cohort study of the population in China, the sudden lifting of the zero COVID policy was associated with significant increases in all-cause mortality. These findings provide valuable insights for policy makers and public health experts and are important for understanding how the sudden propagation of COVID-19 across a population may be associated with population mortality.


    (Continue . . . )



    All nations, to one extent or another, attempt to `manage' bad news. Some just do it more pervasively, and more effectively, than others. And since the COVID pandemic, it has become more `acceptable'.

    We get suspiciously little news on MERS-CoVout of the Middle East, very little surveillance and reporting on avian flu from Asia, Africa, and the Middle East, and 90% of countries no
    longer regularly report on COVID cases, hospitalizations, or deaths
    .


    Some of this can be attributed to the limited ability many countries still have for surveillance (see Lancet Preprint: National Surveillance for Novel Diseases - A Systematic Analysis of 195 Countries), but a lot of it appears to be based on economic, societal, or political considerations.

    While there may be some temporary advantages to these policies, eventually another global public health crisis will emerge, and we risk being caught flat-footed and unprepared.


    Again.

    https://afludiary.blogspot.com/2023/...tality-in.html
    Last edited by Michael Coston; August 29, 2023, 06:14 AM.
    All medical discussions are for educational purposes. I am not a doctor, just a retired paramedic. Nothing I post should be construed as specific medical advice. If you have a medical problem, see your physician.

  • #2
    EID Journal: Estimate of COVID-19 Deaths, China, December 2022–February 2023





    #17,644

    During the first 3 years of the COVID pandemic, China - with a population of 1.4 billion - only admitted to 5242 deaths from the virus. While many countries attempt to `manage' bad news, China has elevated that skill set into an art form.While there were persistent (albeit, unverifiable) reports of crematoriums running 24/7, hospitals overrun, and estimates of hundreds of millions of infections over the next couple of months - officially - COVID was mild and deaths were relatively few.

    Last week, in JAMA Open: Excess All-Cause Mortality in China After Ending the Zero COVID Policy. we saw an estimate of roughly 1.87 million excess deaths in China in the two months following the collapse of Zero COVID.

    Today we've a slightly more conservative estimate published in the CDC's EID journal. While their estimate was 1.41 million deaths over 60 days, that was more than 17-fold higher than `officially' reported by China (n=82,000).

    Due to its length, I've only reproduced some excerpts. Follow the link to read the report in full. I'll have a postscript after the break.

    Volume 29, Number 10—October 2023
    Dispatch

    Estimate of COVID-19 Deaths, China, December 2022–February 2023
    Zhanwei Du, Yuchen Wang, Yuan Bai, Lin Wang, Benjamin John Cowling, and Lauren Ancel Meyers
    Abstract

    China announced a slight easing of its zero-COVID rules on November 11, 2022, and then a major relaxation on December 7, 2022. We estimate that the ensuing wave of SARS-CoV-2 infections caused 1.41 million deaths in China during December 2022–February 2023, substantially higher than that reported through official channels.


    For almost 3 years, China maintained a zero-COVID policy that effectively suppressed SARS-CoV-2 transmission. China began rolling back those rules on November 11, 2022, and ended most restrictions on December 7, 2022 (China Focus, 2023,
    link , in response to the reduced severity of the Omicron variant or the growing socioeconomic and political costs of the restrictions. COVID-19 immediately surged; China reported nearly 82,000 COVID-19–related deaths during December 16, 2022–February 17, 2023 (1).

    In December 2022, China disbanded its national COVID testing system and twice modified its criteria for classifying COVID-19–related deaths (2,3). The resulting uncertainties in reported occurrences and low official death counts have spurred speculation that official mortality reports from China substantially underestimate the full burden of the December 2022–January 2023 wave (4).

    In early December of 2022, the Chinese Center for Disease Control and Prevention (China CDC) launched a sentinel household surveillance program, tracking SARS-CoV-2 test positivity in 420,000 people in 22 provinces across China (
    5). We used those data to estimate a plausible range for the total number of COVID-19–related deaths during December 2022–January 2023. We classified a death as COVID-19–related if it occurred within 28 days of confirmed infection (6).

    (SNIP)

    Conclusions

    COVID-19 deaths are related to a variety of health complications, including septic shock, multiorgan failure, respiratory failure, heart failure, and secondary infections (8). China’s official reports may underestimate the COVID-19 death toll by a factor of 17 (95% CrI 14–22). Our analyses suggest that, in barely a month, COVID-19 killed >1 million persons in China.
    The difference between China’s official mortality reports and our estimates may stem from delays in hospital reporting (
    9), omission of deaths happening outside of hospitals (2), gaps in China’s vital registration system (4), or intentional reclassification after the insurance industry in China largely stopped covering COVID-19 in December 2022 (South China Morning Post, December 17, 2022, LINK).

    (SNIP)
    Our findings rely on the validity of data from the China CDC’s sentinel household surveillance program, which might have some quality issues (e.g., double counting of persons who test multiple times). China CDC reports include graphs of daily positivity in this sample that enable rapid approximation of epidemic trends on a national scale (5). In addition, we assume that reported vaccinations were the only source of prior immunity and that all infections were by Omicron variants; surveillance data suggest that only 0.4% of specimens collected during this period were not Omicron (5).

    In summary, our study suggests that the official mortality reports from China substantially underestimate the full burden of the December 2022–January 2023 COVID-19 wave, raising concerns about the accuracy and transparency of China’s reporting system, as well as potential underestimation of reports from other countries that limit data collection and reporting. The decision to relax China’s zero-COVID policies without adequate measures to protect high-risk populations had severe consequences. Other countries prioritized vaccines for older age groups and other vulnerable populations (13), and many studies have indicated that targeting medical countermeasures and protective measures toward groups with high infection-fatality rates can be life and cost saving (14,15). We expect that the true toll of COVID-19 in China will become clearer as additional epidemiologic data become available.

    Dr. Du is a research assistant professor in the School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. He develops mathematical models to elucidate the transmission dynamics, surveillance, and control of infectious diseases.




    We will probably never know the full impact of COVID on China - or the rest of the world - because there are so many economic and political incentives for officials (from local level up to the national level) to downplay the numbers.

    Officially, roughly 7 million people have died from SARS-CoV-2 globally since December 2019, but the real number is likely 2 or 3 times higher. Today, 90% of countries no longer regularly report COVID hospitalizations or deaths to the WHO on a regular basis.

    While `sanitized' numbers may be good for the economy, or help politicians get re-elected, they can also mask new and emerging threats. But that isn't really a problem until it happens, and in the meantime, we can party like its 2019.



    All medical discussions are for educational purposes. I am not a doctor, just a retired paramedic. Nothing I post should be construed as specific medical advice. If you have a medical problem, see your physician.

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