France - Monkeypox outbreak 2022-2026

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05/07/2022

FOOD AND HUMAN NUTRITION


Monkey pox: what risk of transmission through food?


An increase in the number of people infected with the Monkeypox virus responsible for “monkey pox” has recently been recorded, in France as elsewhere, mainly in Europe. This virus can be transmitted by direct contact with a sick person, as well as by respiratory droplets. ANSES received an emergency request to also assess the risk of transmission of this virus through food.


A risk that cannot be completely excluded

To date, transmission of the virus by ingestion of contaminated food has not been proven.

On the basis of the data available, the Agency nevertheless indicates that the risk of transmission of the Monkeypox virus to humans through food cannot be excluded. A food can thus be contaminated directly by a sick person, in particular if the latter handles it when there are lesions or scabs on the skin. Food can also be contaminated after contact with a surface that is itself contaminated. Transmission to humans through the food could then occur by ingestion or handling of the contaminated food.

Apply good hygiene practices to prevent the risk of transmission

In general, in the event of infection with the virus, the authorities recommend self- isolation . The Agency recalls that when there are infected wounds on the hands, whatever their origin, one should neither handle food nor cook for other people. This also applies in the event of symptoms evoking monkey pox (rashes, fever, headaches, fatigue, muscle pain, etc.).

In addition, the Agency recommends that professionals in the catering or food industry:

1. make workers aware of the symptoms of this virus so that they can declare themselves quickly in the event of infection and allow the effective management of contact persons;
2. as the virus is persistent in the environment, apply good hygiene, cleaning and disinfection practices for equipment and premises to limit contamination in spaces that may have been frequented by infected people.

This referral follows that relating to the risk of transmission of the virus to pets .

https://www.anses.fr/fr/content/variole-du-singe-quel-risque-de-transmission-par-l%E2%80%99alimentation

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Case of monkeypox: update on July 5, 2022

Update on 05/07/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.

Posted on July 5, 2022
...

Case of monkeypox: update in France

As of July 05, 2022 at 2 p.m., 577 cases have been confirmed: 387 in Ile-de-France, 52 in Auvergne-Rhône-Alpes, 37 in Occitanie, 30 in New Aquitaine, 23 in Hauts-de-France, 21 in Provence -Alpes-Côte d'Azur, 8 in Normandy, 6 in Grand Est, 5 in Brittany, 4 in Pays-de-la-Loire, 3 in Bourgogne-Franche-Comté and 1 in Centre-Val de Loire.

As of July 4, 2022 at 2:00 p.m., the distribution by region of residence of the 552 confirmed cases that have been investigated is presented in Figure 1.

Figure 1. Confirmed cases of monkeypox (n=552), by region of residence, France, May-July 2022 (data as of 04/07/2022 – 2:00 p.m.)


Among these cases, 3 women and 1 child have been infected with the monkeypox virus since May 7, 2022, the date of the first case detected in France.

Confirmed adult cases are between 19 and 71 years old (median age: 35 years).

Symptom onset dates range between May 7, 2022 and July 01, 2022 (Figure 2). These cases were diagnosed a median of 6 days (range 0 to 22 days) after the onset of symptoms; therefore, data for the last week is not consolidated.

Figure 2. Confirmed cases of monkeypox (n=552), by date of onset of symptoms, France, May-July 2022 (data as of 04/07/2022 – 2:00 p.m.)


Among the cases investigated, 78% presented a genito-anal rash, 73% an eruption on another part of the body, 75% a fever and 72% lymphadenopathy.

Among the cases investigated, 29 are immunocompromised; 149 are HIV-positive (27%) and no cases have died.

To date, in France, 97% of cases for which sexual orientation is provided have occurred in men who have sex with men (MSM). Among the cases for which information is available, 75% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases investigated declare that they cannot identify the person who allegedly infected them; 100 are secondary cases, ie having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

Information and prevention actions

Given what has been observed in Europe on the disease, targeted communication was quickly implemented towards MSM people. The sexosafe.fr site, dedicated to the sexuality of MSM people, has been updated with a summary of knowledge on the subject and preventive measures. The messages recalling the symptoms and what to do in the event of symptoms were relayed via a digital campaign, posters and flyers and then actions in the field. Since June 17, the digital campaign has generated nearly 192,000 banner clicks and more than 173,000 visits to the sexosafe site. This device was supplemented with a poster campaign in places of conviviality with nearly 1,350 poster spaces. At the same time, posters, flyers and advice sheets were distributed thanks to associations, to the ARS and the Sexosafe teams present in the field, within the framework of the pride marches and in the places of conviviality MSM. To date, 1,514 posters and 57,500 flyers have been ordered.
Prevention actions are continuously adapted to the evolution of the situation and the state of knowledge.

1. Access the documents:
   • Sign smallpox info | Attach
   • Monkey pox info - Monkeypox | Flyer

In the usual absence of monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term monitoring of monkeypox by means of compulsory reporting is reinforced and information and alert messages are sent to health professionals . Exchanges are also continuing with other European countries, the WHO and the ECDC.

...
https://www.santepubliquefrance.fr/l...5-juillet-2022

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Case of monkeypox: update on July 7, 2022

Update on 07/07/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.


Posted on July 8, 2022

...
Case of monkeypox: update in France

As of July 07, 2022 at 12:00 p.m., 721 cases have been confirmed: 473 in Ile-de-France, 70 in Auvergne-Rhône-Alpes, 52 in Occitanie, 33 in New Aquitaine, 29 in Hauts-de-France, 28 in Provence -Alpes-Côte d'Azur, 11 in Normandy, 10 in Grand Est, 6 in Brittany, 4 in Pays-de-la-Loire, 3 in Bourgogne-Franche-Comté and 2 in Centre-Val de Loire.

As of 6 July 2022 at 12:00 p.m., the distribution by region of residence of the 652 confirmed cases residing in France which have been investigated is presented in figure 1. In addition, 4 additional cases reside abroad.

Figure 1. Confirmed cases of monkeypox (n=652), by region of residence, France, May-July 2022 (data as of 06/07/2022 – 12:00 p.m.)



Among these cases, a new pediatric case under 10 years old and a new female case were reported. In total, 2 children and 4 women have therefore been identified to date among all the cases infected with the monkeypox virus since May 7, 2022, the date of the first case detected in France.

Confirmed adult cases are between 19 and 71 years old (median age: 35 years).

Symptom onset dates range between May 7, 2022 and July 1, 2022 (Figure 2). These cases were diagnosed a median of 6 days (range 0 to 22 days) after the onset of symptoms; therefore, data for the last week is not consolidated.

Among the cases investigated, the median time to use the test per screening week has decreased since the start of the epidemic, going from 13 days in S18-2022 (May 2 to 8) to 5 days in S25-2022 (20 to June 26).

Figure 2. Confirmed cases of monkeypox (n=656), by date of onset of symptoms, France, May-July 2022 (data as of 06/07/2022 – 12:00 p.m.)



Among the cases investigated, 81% presented a genito-anal rash, 74% an eruption on another part of the body, 79% a fever and 75% lymphadenopathy.

Among the cases investigated, 34 are immunocompromised; 174 are HIV positive (27%). Among the HIV-free cases, 314 are on PreP (69%). No cases died.

To date, in France, 98% of cases for which sexual orientation is provided have occurred among men who have sex with men (MSM). Among the cases for which information is available, 75% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases investigated declare that they cannot identify the person who allegedly infected them; 118 are secondary cases, ie reporting having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Wednesday July 13, 2022.

Information and prevention actions

Given what has been observed in Europe on the disease, targeted communication was quickly implemented towards MSM people. sexosafe.fr website, dedicated to the sexuality of MSM people, has been updated with a summary of knowledge on the subject and prevention measures. The messages recalling the symptoms and what to do in the event of symptoms were relayed via a digital campaign. Since June 17, the digital campaign has generated nearly 220,817 clicks on the banners and more than 204,999 visits to the Sexosafe site. This device was supplemented with a poster campaign in places of conviviality with nearly 1,350 poster spaces. At the same time, posters, flyers and advice sheets were distributed thanks to associations, ARS and Sexosafe teams present in the field, as part of pride marches and in places where MSM meet. To date, 1,626 posters and 62,850 flyers have been ordered.

Prevention actions are continuously adapted to the evolution of the situation and the state of knowledge.

1. Access the documents:
   • Sign smallpox info | Attach
   • Monkey pox info - Monkeypox | Flyer

In the usual absence of monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term surveillance of monkeypox through the mandatory notification system is reinforced and information and alert messages are sent to health professionals. Exchanges are also continuing with other European countries, the WHO and the ECDC.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-variole-du-singe-point-de-situation-au-7-juillet-2022

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Monkeypox: a preventive vaccination offered to people most at risk of exposure


PRESS RELEASE - Posted on Jul 08, 2022


July 8, 2022

Faced with the spread of the Monkeypox virus , the kinetics of the epidemic and the difficulties of tracing the contacts of infected people, the General Directorate of Health contacted the High Authority for Health on the relevance of extending vaccination, which is currently reactive. . HAS recommends that preventive vaccination be offered to the groups most exposed to the virus: men who have sex with men and trans people who have multiple partners, people in prostitution, professionals working in places of consumption sexual. It can be considered on a case-by-case basis for professionals who have to take care of sick people.

To deal with the appearance of the first cases of Monkeypoxin France, the High Authority for Health recommended on May 20 a post-exposure reactive vaccination of people whose contact with an infected person is considered to be at risk of exposure. Since then, the number of cases has increased, with 577 confirmed cases as of July 5, including 387 in Ile-de-France. The cases remain, at this stage, not very serious, the disease progressing favorably in a few weeks. These data, established by Public Health France, show that these cases occurred mainly in men, and when this information is provided, in 97% of cases, they are men who have sex with men (MSM) and in 75% of cases of men reporting having had several partners in the weeks preceding the onset of symptoms. Seized by the General Directorate of Health,Monkeypox in order to determine to which populations it is relevant to extend vaccination, particularly in prevention, to limit the risk of contamination for people at risk of exposure to the virus.

Offer vaccination to people exposed through their sexual practices or their profession

The Monkeypox virus is transmitted by contact of the skin or mucous membranes with the damaged skin of an infected person (pimples or scabs) and by droplets (saliva, sneezing, sputter, etc.). Public Health France defines that a person is considered to be at risk of exposure when there has been direct unprotected physical contact (with damaged skin) or unprotected contact within 2 meters and for 3 cumulative hours on a period of 24 hours. However, contact tracing operationsencounter difficulties: impossibility of identifying the person who transmitted the virus, under-declaration of contact cases, in particular around anonymous sexual relations. HAS also took into consideration the efficacy data of available vaccines as well as the opinion of the National Agency for the Safety of Medicines and Health Products (ANSM) on the favorable risk-benefit of 3rd generation vaccines ⁱⁿ preexposure. It has also analyzed the recommendations of various foreign countries which have decided on preventive vaccination against Monkeypox : Germany, United Kingdom, Belgium, Spain, Australia, Canada, United States.

On the basis of these elements, in addition to post-exposure vaccination around a confirmed case, HAS recommends offering vaccination against Monkeypox in pre-exposure to people most exposed to the virus. These are prioritized as follows:

• Men who have sex with men (MSM) and trans people reporting multiple sexual partners;
• People in a situation of prostitution;
• Professionals in places of sexual consumption, regardless of the status of these places;

HAS does not recommend, at this stage, pre-exposure vaccination of healthcare professionals caring for sick people, the usual hygiene measures and the wearing of personal protective equipment making the risk of contamination very low in practice. Nevertheless, the HAS recommends that this vaccination can be considered on a case-by-case basis, depending on exposure, the existence of individual risk factors or at their request.

The HAS recalls that the vaccination schedule consists of two doses, 28 days apart, a reduced schedule to one dose for people who have already been vaccinated against smallpox. The characteristics of the two available vaccines allow their interchangeability: the second dose can thus be given with a different vaccine from the first. Finally, a spacing of doses of several weeks could be envisaged in the event of a tension in the supply of vaccines.

Finally, it emphasizes that compliance with simple hygiene and prevention measures makes it possible to avoid transmission and to protect oneself effectively from the virus and calls for them to be applied, whether in a hospital environment or at home, including after being vaccinated.

The HAS specifies that it will update its recommendations according to the new data available.

...

https://www.has-sante.fr/jcms/p_3351443/fr/monkeypox-une-vaccination-preventive-proposee-aux-personnes-les-plus-a-risque-d-exposition

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Case of monkeypox: update on July 12, 2022

Update on 07/12/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.


Posted on July 13, 2022

...
Case of monkeypox: update in France

As of July 12, 2022 at 2 p.m., 912 cases have been confirmed: 569 in Ile-de-France, 87 in Auvergne-Rhône-Alpes, 68 in Occitanie, 47 in New Aquitaine, 47 in Provence-Alpes-Côte d'Azur, 34 in Hauts-de-France, 18 in Grand Est, 13 in Normandy, 9 in Brittany, 8 in Centre-Val de Loire, 5 in Pays-de-la-Loire, 3 in Bourgogne-Franche-Comté and 4 cases in the stranger.

As of 11 July 2022 at 12:00 p.m., the distribution by region of residence of the 824 confirmed cases residing in France who have been investigated is presented in figure 1.

Figure 1. Confirmed cases of monkeypox (n=824), by region of residence, France, May-July 2022 (data as of 07/11/2022 – 12:00 p.m.)



The description of the 828 confirmed cases that have been investigated is given below.

Among all the confirmed cases, 5 female adult cases and 2 children are identified.

Adult cases are between 19 and 84 years old (median age: 36 years).

Symptom onset dates range between May 7, 2022 and July 7, 2022 (Figure 2). These cases were diagnosed a median of 6 days (range 0 to 22 days) after the onset of symptoms; therefore, data for the last week is not consolidated.

Among the cases investigated, the median time taken to use the test per screening week has fallen sharply since the start of the epidemic, going from 13 days in S18-2022 (May 2 to 8) to 4 days in S26-2022 ( June 27 to July 03).

Figure 2. Confirmed cases of monkeypox (n=828), by date of onset of symptoms, France, May-July 2022 (data as of 07/11/2022 – 12:00 p.m.)



Among the cases, 81% presented a genito-anal rash, 73% a rash on another part of the body, 78% a fever, 76% lymphadenopathy and 37% a sore throat.

Of the cases, 40 are immunocompromised; 211 are HIV positive (26%). Among the HIV-free cases, 403 are on PreP (70%). No case died.

To date, in France, 97% of cases for which sexual orientation is reported have occurred among men who have sex with men (MSM). Among the cases for which information is available, 75% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most cases report not being able to identify the person who allegedly infected them; 153 are secondary cases, ie reporting having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Wednesday July 20, 2022.
...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-variole-du-singe-point-de-situation-au-12-juillet-2022

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A second case of monkeypox detected in Corsica

Published on07/19/2022 at 7:44 p.m.
Written by Sebastien Bonifay

A person, who had been in contact at risk with a case on the continent, in turn developed monkey pox in Corsica.

The ARS wanted to be reassuring in its press release. Like the first case , detected on June 26, this new patient with the Monkeypox virus, which gives monkeypox, shows "no sign of seriousness" . This first person, who resided in Occitania, was repatriated to his home.

This second case was, we learn from the ARS, "already identified as a risk contact of a confirmed case outside Corsica" . According to the health agency, “early isolation, and the application of the recommended barrier measures, made it possible to avoid any risky contact” .
...

https://france3-regions.francetvinfo.fr/corse/un-deuxieme-cas-de-variole-du-singe-detecte-en-corse-2584188.html

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Case of monkeypox: update on July 19, 2022

Update on 07/19/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.

Posted on July 20, 2022
...

Update in France

Due to increased delays in collecting information on recently observed cases, the total number of confirmed cases published today includes catch-up data. The increase in the number of cases since the last report published is spread over the last few weeks and should not be interpreted as an exceptional increase, although an upward trend is nevertheless observed. Data for cases identified to date are presented as of the date of onset of symptoms or, if unknown, as of the date of report. This has no impact on patient information and care.

As of July 19, 2022 at 12:00 p.m., 1,453 confirmed cases have been identified in France; by department of residence, 678 cases reside in Ile-de-France, 111 in Occitanie, 103 in Auvergne-Rhône-Alpes, 65 in New Aquitaine, 55 in Provence-Alpes-Côte d'Azur, 41 in Hauts-de- France, 25 in Grand Est, 18 in Normandy, 15 in Pays-de-la-Loire, 9 in Bourgogne-Franche-Comté, 9 in Centre-Val de Loire, 9 in Brittany and 1 in Martinique. The region of residence is not given for 309 cases and 5 cases live abroad.

The distribution of cases by region of residence (when known) is shown in Figure 1 for cases residing in France. That by reporting region is shown in Figure 2.

Figure 1. Confirmed monkeypox cases (n=1,139 cases) by region of residence, France, May-July 2022 (data as of 07/19/2022 – 12:00 p.m.)


Figure 2. Confirmed monkeypox cases (n=1,440 cases) by reporting region, France, May-July 2022 (data as of 07/19/2022 – 12:00 p.m.)


The distribution of cases by symptom onset date (when known) is shown in Figure 3. The symptom onset date for these cases ranges between May 7, 2022 and July 15, 2022. They have were diagnosed a median of 6 days (between 0 and 23 days) after the onset of symptoms; therefore, data for the last week is not consolidated.

The reports received do not always mention the date of onset of symptoms or the date of diagnosis of the patient. As an alternative to this information, the distribution of cases according to their date of reporting is presented in Figure 4.

Figure 3. Confirmed cases of monkeypox (n=1,087 cases) by date of onset of symptoms, France, May-July 2022 (data as of 07/19/2022 – 12:00 p.m.)


Figure 4. Confirmed cases of monkeypox (n= 1,299 cases) by date of report, France, May-July 2022 (data as of 07/19/2022 – 12:00 p.m.)


All cases identified to date, except 6 adult females and 2 children, are adult males. Adult cases range in age from 18 to 84 (median age: 36).

Among the cases investigated, 78% presented a genito-anal rash, 72% an eruption on another part of the body, 76% a fever and 74% lymphadenopathy. No cases died.

The median time to use the test per screening week has decreased since the start of the epidemic: it fell from 13 days in S18-2022 (May 2 to 8) to 5 days in S26-2022 (July 4 to 10 ).

Among the cases investigated, 49 are immunocompromised; 274 (26%) are HIV positive. Among HIV-negative cases, 513 (69%) are on PreP.

To date, in France, 96% of cases for which sexual orientation is reported have occurred among men who have sex with men (MSM). Among the cases for which information is available, 74% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases questioned declare that they cannot identify the person who allegedly infected them; 212 are secondary cases, ie reporting having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Friday July 22, 2022.

Information and prevention actions

Given what has been observed in Europe on the disease, targeted communication was quickly implemented towards MSM people. The site sexosafe.fr,dedicated to the sexuality of MSM people, is regularly updated with a summary of knowledge on the subject and prevention measures. The messages recalling the symptoms and what to do in the event of symptoms were relayed via a digital campaign. Since June 17, the digital campaign has generated nearly 348,592 clicks on the banners and more than 292,993 visits to the Sexosafe site. This device was supplemented with a poster campaign in places of conviviality with nearly 1,350 poster spaces. And since a few days by broadcasting spots on community radios. At the same time, posters, flyers and advice sheets were distributed thanks to associations, ARS and Sexosafe teams present in the field, in the context of Pride marches and in places of MSM conviviality. To date, 2,657 posters and 80,100 flyers have been ordered.

In the days to come, a digital campaign on preventive vaccination and tools for the field will also be made available, following the publication of the opinion of the High Authority for Health of July 07.

Prevention actions are continuously adapted to the evolution of the situation and the state of knowledge.

• Access the documents:
  • Monkey pox info | Attach
  • Monkey pox info - Monkeypox | Flyer

In the usual absence of monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term monitoring of monkeypox by means of compulsory reporting is reinforced and information and alert messages are sent to health professionals . Exchanges are also continuing with other European countries, the WHO and the ECDC.

Monkeypox info service: a listening device to answer questions about monkeypox

Since Wednesday, July 13, a listening device has been open to answer questions raised by monkeypox. Subsidized by Public Health France and supported by SIS Association (Sexualités info service Association), the “Monkeypox info service” telephone line is accessible every day from 8 a.m. to 11 p.m., on the toll-free number 0 801 90 80 69 (free call and services, anonymous and confidential) This device is in charge of accompanying prevention messages and protective measures, of providing information on symptoms, treatments and vaccination, of advising and directing towards the care devices.

• Since the opening of the line, 879 requests have been processed on the Monkeypox info service line, 91% of them from men, with an average age of 39 years.
• Less than half of callers (41%) declare a risk of exposure and 12% of callers say they have the virus.
• The theme mainly mentioned is the means of prevention: 9 requests out of 10 relate to access to the vaccine. Among these requests related to the vaccine, the main concerns regarding the accessibility of vaccination and requests for addresses of vaccination centers.
• Callers also wonder about the symptoms, the risks of transmission and testify to their concerns about the transmission of the virus.

Learn more

Preventive vaccination against monkeypox

Faced with the spread of the Monkeypox virus (monkey pox), the High Authority for Health, seized by the Directorate General for Health, recommended in its opinion of July 7, 2022 that preventive vaccination be offered to the groups most exposed to the virus. .

Thus, since July 11, 2022, in addition to people who have had risky contact with a sick person, people falling within the indications retained by the HAS can make an appointment to be vaccinated throughout the country:

• Men who have sex with men reporting multiple sex partners.
• Trans people reporting multiple sexual partners.
• People in prostitution.
• Professionals working in places of sexual consumption.

Vaccination can also be considered on a case-by-case basis for health professionals who have to take care of sick people.
For more information on vaccination and access to vaccination sites:

• https://www.sante.fr/monkeypox
• https://www.sexosafe.fr/Variole-du-singe
• https://vaccination-info-service.fr/Les- Maladies-et-leurs-vaccins/Variole-du-singe-Monkeypox
• https://www.iledefrance.ars.sante.fr...-ile-de-france

...
https://www.santepubliquefrance.fr/l...9-juillet-2022

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Case of monkeypox: update on July 26, 2022

Update on 07/26/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.

Posted on July 27, 2022
...

Update in France

As of July 26, 2022 at 12 p.m., 1,837 confirmed cases have been identified in France. The cases most frequently resided in Ile-de-France (781 cases, i.e. 55% of cases whose region of residence is known), in Occitanie (151 cases, i.e. 11%) and in Auvergne-Rhône-Alpes (150 cases, i.e. 10%).

The distribution of cases by region of residence (when known) is shown in Figure 1 for cases residing in France. That by reporting region is shown in Figure 2.

The region of residence is not given for 407 cases and 6 cases live abroad.

Figure 1. Confirmed cases of monkeypox (n=1,424 cases) by region of residence, France, May-July 2022 (data as of 07/26/2022 – 12:00 p.m.)



Figure 2. Confirmed monkeypox cases (n=1,829 cases) by reporting region, France, May-July 2022 (data as of 07/26/2022 – 12:00 p.m.)


The distribution of cases by symptom onset date (when known) is shown in Figure 3. The case symptom onset date ranges from 7 May 2022 to 22 July 2022. They were diagnosed a median of 6 days (between 0 and 23 days) after the onset of symptoms; as a result and given the reporting deadlines, the data for the last few weeks is not consolidated.

The reports received do not always mention the date of onset of symptoms or the date of diagnosis of the patient. As an alternative to this information, the distribution of cases according to their date of reporting is presented in Figure 4.

Figure 3. Confirmed cases of monkeypox (n=1,349 cases) by week of onset of symptoms, France, May-July 2022 (data as of 07/26/2022 – 12:00 p.m.). The data for the last few weeks (in grey) are not fully consolidated.


Figure 4. Confirmed cases of monkeypox (n= 1,684 cases) by reporting week, France, May-July 2022 (data as of 07/26/2022 – 12:00 p.m.).


All cases identified to date are adult males except 12 adult females and 2 children. Adult cases have a median age of 36; 25% of adult cases are under 30 years old and 25% are between 43 and 84 years old.

Among the cases investigated, 76% presented a genito-anal rash, 72% an eruption on another part of the body, 76% a fever and 73% lymphadenopathy.

Forty cases (3.0%) were hospitalized because of their Monkeypox virus infection, including 34 (2.7%) for complications related to this diagnosis. No case died.

The median time to use the test per week of onset of symptoms has decreased since the start of the epidemic: it fell from 13 days in S18-2022 (May 2 to 8) to 5 days in S26-2022 (June 26 to July 3).

Among the cases investigated, 53 are immunocompromised (4.5% of the cases having responded); 318 are HIV positive (i.e. 26% of cases knowing their HIV status).
Among cases without HIV, 604 are on pre-exposure prophylaxis or “PrEP”* (i.e. 68% of respondents to the question).

To date, in France, 96% of cases for which sexual orientation is reported have occurred among men who have sex with men (MSM). Among the cases for which information is available, 74% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases questioned declare that they cannot identify the person who allegedly infected them; 255 are secondary cases, ie reporting having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Friday July 29, 2022.

*PrEP is an HIV preventive treatment intended for people who do not carry the virus and who are particularly exposed to it.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-variole-du-singe-point-de-situation-au-26-juillet-2022

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Case of monkeypox: update on July 28, 2022

Update on 07/28/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.

Posted on July 29, 2022
...

Update in France

As of July 28, 2022 at 12 p.m., 1,955 confirmed cases have been identified in France. The cases resided most frequently in Ile-de-France (814 cases or 53% of cases whose region of residence is known), in Occitanie (170 cases, or 11%) and in Auvergne-Rhône-Alpes (161 cases, i.e. 10%).

The distribution of cases by region of residence (when known) is shown in Figure 1 for cases residing in France. That by reporting region is shown in Figure 2.

The region of residence is not given for 406 cases and 7 cases live abroad.

Figure 1. Confirmed cases of monkeypox (n=1,542 cases) by region of residence, France, May-July 2022 (data as of 07/28/2022 – 12:00 p.m.)


Figure 2. Confirmed monkeypox cases (n=1,951 cases) by reporting region, France, May-July 2022 (data as of 07/28/2022 – 12:00 p.m.)


The distribution of cases by symptom onset date (when known) is shown in Figure 3. The case symptom onset date ranges from May 7, 2022 to July 22, 2022. diagnosed a median of 6 days (between 0 and 23 days) after the onset of symptoms; as a result and given the reporting deadlines, the data for the last few weeks is not consolidated.

The reports received do not always mention the date of onset of symptoms or the date of diagnosis of the patient. As an alternative to this information, the distribution of cases according to their date of reporting is presented in Figure 4.

Figure 3. Confirmed cases of monkeypox (n=1,452 cases) by week of onset of symptoms, France, May-July 2022 (data as of 07/28/2022 – 12:00 p.m.). The data for the last few weeks (in grey) are not fully consolidated.


Figure 4. Confirmed cases of monkeypox (n= 1,796 cases) by reporting week, France, May-July 2022 (data as of 07/28/2022 – 12:00 p.m.). Data for the last week (in grey) are not fully consolidated.


All cases identified to date are adult males, except 12 adult females and 2 children (under 15). Adult cases have a median age of 36; 25% of adult cases are under 30 years old and 25% are between 43 and 84 years old.

Among the cases investigated, 76% presented a genito-anal rash, 72% an eruption on another part of the body, 76% a fever and 72% lymphadenopathy.

Forty-two cases (2.9%) were hospitalized because of their Monkeypox virus infection, including 35 (2.6%) for complications related to this diagnosis. No cases died.

The median time to use the test by date of onset of symptoms has decreased since the start of the epidemic: it fell from 13 days in S18-2022 (May 2 to 8) to 5 days in S26-2022 (June 27 to July 3).

Among the cases investigated, 56 are immunocompromised (4.5% of the cases having responded); 338 are HIV positive (i.e. 26% of cases knowing their HIV status).

Among the non-HIV carriers, 631 are on pre-exposure prophylaxis or “PrEP”* (i.e. 67% of the non-HIV carriers who answered the question).

To date, in France, 96% of cases for which sexual orientation is reported have occurred among men who have sex with men (MSM). Among the cases for which information is available, 73% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases questioned declare that they cannot identify the person who allegedly infected them; 24% are secondary cases, ie they report having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Wednesday August 3, 2022.

*PrEP is an HIV preventive treatment intended for people who do not carry the virus and who are particularly exposed to it.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-variole-du-singe-point-de-situation-au-28-juillet-2022

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Case of monkeypox: update on August 2, 2022

Update on 02/08/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.

Posted on August 3, 2022
...

Update in France

As of August 2, 2022 at 12 p.m., 2,239 confirmed cases have been identified in France. The cases resided most frequently in Ile-de-France (845 cases or 50% of cases whose region of residence is known), in Occitanie (196 cases, or 12%) and in Auvergne-Rhône-Alpes (173 cases, i.e. 10%).

The distribution of cases by region of residence (when known) is shown in Figure 1 for cases residing in France. That by reporting region is shown in Figure 2.

The region of residence is not given for 543 cases and 7 cases live abroad.

Figure 1. Confirmed monkeypox cases (n=1,689 cases) by region of residence, France, May-August 2022 (data as of 02/08/2022 – 12:00 p.m.)



Figure 2. Confirmed monkeypox cases (n=2,234 cases) by reporting region, France, May-August 2022 (data as of 08/02/2022 – 12:00 p.m.)



The distribution of cases by symptom onset date (when known) is shown in Figure 3. The case symptom onset date ranges from May 7, 2022 to July 27, 2022. diagnosed a median of 6 days (between 0 and 23 days) after the onset of symptoms; as a result and given the reporting deadlines, the data for the last few weeks is not consolidated.

The reports received do not always mention the date of onset of symptoms or the date of diagnosis of the patient. As an alternative to this information, the distribution of cases according to their date of reporting is presented in Figure 4.

Figure 3. Confirmed cases of monkeypox (n=1,578 cases) by week of onset of symptoms, France, May-August 2022 (data as of 08/02/2022 – 12:00 p.m.). The data for the last few weeks (in grey) are not fully consolidated.



Figure 4. Confirmed cases of monkeypox (n= 2,087 cases) by reporting week, France, May-August 2022 (data as of 02/08/2022 – 12:00 p.m.).



All cases identified to date are adult males, except 15 adult females and 2 children (under 15). Adult cases have a median age of 36; 25% of adult cases are under 30 years old and 25% are between 43 and 84 years old.

Among the cases investigated, 75% presented a genito-anal rash, 71% an eruption on another part of the body, 76% a fever and 72% lymphadenopathy.
Forty-five cases (2.9%) were hospitalized because of their Monkeypox virus infection, including 37 (2.6%) for complications related to this diagnosis. In France, no deaths have been reported to date.

The median time to use the test by date of onset of symptoms has decreased since the start of the epidemic: it fell from 13 days in S18-2022 (May 2 to 8) to 5 days in S27-2022 (4 to July 10).

Of the cases investigated, 67 are immunocompromised (5.0% of cases responding); 358 are HIV positive (i.e. 26% of cases knowing their HIV status). Among the non-HIV carriers, 662 are on pre-exposure prophylaxis or “PrEP”* (i.e. 66% of the non-HIV carriers who answered the question).

To date, in France, 96% of cases for which sexual orientation is reported have occurred among men who have sex with men (MSM). Among the cases for which information is available, 72% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases questioned declare that they cannot identify the person who allegedly infected them; 24% are secondary cases, ie they report having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Friday, August 5, 2022.

*PrEP is an HIV preventive treatment for people who do not have HIV and are particularly at risk.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-variole-du-singe-point-de-situation-au-2-aout-2022

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Case of monkeypox: update on August 4, 2022

Update on 04/08/22 following the cases of monkey pox (Monkeypox) reported in France and around the world.

Posted on August 5, 2022
...

Cases of monkeypox (Monkeypox) not directly linked to travel to Central or West Africa or people returning from travel have been reported in Europe and around the world since the beginning of May 2022. Since this date , the epidemic affects a growing number of countries and the disease is the subject, in France and in Europe, of heightened surveillance.

The Director General of the WHO announced on Saturday July 23 that he was declaring a public health emergency of international concern regarding this epidemic. This is the organization's highest level of alert to trigger a series of actions by member countries.

In France, orthopoxvirus infections are subject to long-term monitoring through the mandatory notification system. Given the current epidemic, surveillance of these infections has been reinforced by Public Health France and information and alert messages have been sent to health professionals and the populations most at risk.

Update in France

As of August 4, 2022 at 12 p.m., 2,423 confirmed cases have been identified in France. The cases resided most frequently in Ile-de-France (862 cases or 49% of cases whose region of residence is known), in Occitanie (210 cases, or 12%) and in Auvergne-Rhône-Alpes (181 cases, i.e. 10%).

The distribution of cases by region of residence (when known) is shown in Figure 1 for cases residing in France. That by reporting region is shown in Figure 2.

The region of residence is not given for 653 cases and 8 cases live abroad.

Figure 1. Confirmed cases of monkeypox (n=1,762 cases) by region of residence, France, May-August 2022 (data as of 04/08/2022 – 12:00 p.m.)



Figure 2. Confirmed monkeypox cases (n=2,420 cases) by reporting region, France, May-August 2022 (data as of 08/04/2022 – 12:00 p.m.)



The distribution of cases by symptom onset date (when known) is shown in Figure 3. The case symptom onset date ranges from May 7, 2022 to July 30, 2022. diagnosed a median of 6 days (between 0 and 36 days) after the onset of symptoms; as a result and given the reporting deadlines, the data for the last few weeks is not consolidated.

The reports received do not always mention the date of onset of symptoms or the date of diagnosis of the patient. As an alternative to this information, the distribution of cases according to their date of reporting is presented in Figure 4.

Figure 3. Confirmed cases of monkeypox (n=1,643 cases) by week of onset of symptoms, France, May-August 2022 (data as of 08/04/2022 – 12:00 p.m.). The data for the last few weeks (in grey) are not fully consolidated.



Figure 4. Confirmed cases of monkeypox (n= 2,422 cases) by reporting week, France, May-August 2022 (data as of 04/08/2022 – 12:00 p.m.). Data for the last week (in grey) are not fully consolidated.



The reporting low observed in week 28 (July 11 to 17) can be explained by the public holiday (July 14).

All cases identified to date are adult males except 20 adult females and 2 children (under 15). Adult cases have a median age of 36; 25% of adult cases are under 30 years old and 25% are between 43 and 84 years old.

Among the cases investigated, 75% presented a genito-anal rash, 70% an eruption on another part of the body, 76% a fever and 72% lymphadenopathy.

Forty-seven cases (2.9%) were hospitalized because of their Monkeypox virus infection, including 39 (2.6%) for complications related to this diagnosis. In France, no deaths have been reported to date.

The median time to use the test by date of onset of symptoms has decreased since the start of the epidemic: it fell from 13 days in S18-2022 (May 2 to 8) to 5 days in S27-2022 (4 to July 10).

Of the cases investigated, 69 are immunocompromised (5.0% of cases responding); 369 are HIV positive (i.e. 26% of cases knowing their HIV status). Among non-HIV carriers, 677 are on pre-exposure prophylaxis or “PrEP”* (i.e. 65% of non-HIV carriers who answered the question).

To date, in France, 96% of cases for which sexual orientation is reported have occurred among men who have sex with men (MSM). Among the cases for which information is available, 72% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases questioned declare that they cannot identify the person who allegedly infected them; 24% are secondary cases, ie they report having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Wednesday 10 August.

*PrEP is an HIV preventive treatment for people who do not have HIV and are particularly at risk.

https://www.santepubliquefrance.fr/l...au-4-aout-2022

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Case of monkeypox: update on August 9, 2022

Update on 08/09/22 following the cases of monkey pox (Monkeypox in English) reported in France and around the world.

Posted on August 10, 2022
...

Update in France

As of August 9, 2022 at 12 p.m., 2,601 confirmed cases have been identified in France. The cases most frequently resided in Ile-de-France (885 cases or 47% of cases whose region of residence is known), in Occitanie (230 cases, or 12%) and in Auvergne-Rhône-Alpes (192 cases, i.e. 10%).

The distribution of cases by region of residence (when known) is shown in Figure 1 for cases residing in France. That by reporting region, when this is known, is shown in Figure 2.

The region of residence is not given for 699 cases and 10 cases live abroad.

Figure 1. Confirmed monkeypox cases (n=1,892 cases) by region of residence, France, May-August 2022 (data as of 08/09/2022 – 12:00 p.m.)



Figure 2. Confirmed monkeypox cases (n=2,600 cases) by reporting region, France, May-August 2022 (data as of 08/09/2022 – 12:00 p.m.)



The distribution of cases by symptom onset date (when known) is shown in Figure 3. The case symptom onset date ranges from May 7, 2022 to August 4, 2022. diagnosed a median of 6 days (between 0 and 36 days) after the onset of symptoms; as a result and given the reporting deadlines, the data for the last few weeks is not consolidated.
The reports received do not always mention the date of onset of symptoms or the date of diagnosis of the patient. As an alternative to this information, the distribution of cases according to their date of reporting is presented in Figure 4.

Figure 3. Confirmed monkeypox cases (n=1,766 cases) by week of onset of symptoms, France, May-August 2022 (data as of 08/09/2022 – 12:00 p.m.). The data for the last few weeks (in grey) are not fully consolidated.



Figure 4. Confirmed cases of monkeypox (n=2,600 cases) by reporting week, France, May-August 2022 (data as of 08/09/2022 – 12:00 p.m.). Data for the last week (in grey) is not fully consolidated.Data for the last few weeks (in grey) is not fully consolidated.



The reporting low observed in week 28 (July 11 to 17) can be explained by the public holiday (July 14).

All cases identified to date are adult males, except 23 adult females and 2 children (under 15). Adult cases have a median age of 36; 25% of adult cases are under 30 years old and 25% are 43 to 77 years old.

Among the cases investigated, 75% presented a genito-anal rash, 70% an eruption on another part of the body, 76% a fever and 72% lymphadenopathy.

Fifty-one cases (3%) were hospitalized because of their Monkeypox virus infection, including 43 (2.7%) for complications related to this diagnosis. In France, no deaths have been reported to date.

The median time to use the test by date of onset of symptoms has decreased since the start of the epidemic (Table 1).

Table 1. Median time to use the test in days (n=1,519 cases) by date of onset of symptoms, France, May-August 2022 (data as of 08/09/2022 – 12:00 p.m.)

S18	13
S19	9
S20	9.5
S21	8
S22	7
S23	6
S24	6
S25	6
S26	5
S27	5
S28	6
S29	5

*DDS: Symptom onset date. The data for the last few weeks (in grey) are not fully consolidated.

Among the cases investigated, 74 are immunocompromised (5.1% of the cases having responded); 385 are HIV positive (i.e. 25% of cases knowing their HIV status).

Among non-HIV carriers, 701 are on pre-exposure prophylaxis or “PrEP”** (i.e. 64% of non-HIV carriers who answered the question).

To date, in France, 95% of cases for which sexual orientation is given have occurred in men who have sex with men (MSM).

Among the cases for which information is available, 71% declare having had at least 2 sexual partners in the 3 weeks before the onset of symptoms.

Most of the cases questioned declare that they cannot identify the person who allegedly infected them; 24% are secondary cases, ie they report having been in contact with a case of monkeypox in the three weeks preceding the onset of symptoms.

The next update of this report will take place on Friday 12 August.

**PrEP is an HIV preventive treatment intended for people who do not have HIV and who are particularly at risk.

As of Thursday, August 11, surveillance is changing, only female, pediatric and serious cases will be investigated. Therefore, information on symptomatology and case profiles will no longer be updated at the next review.

Information and prevention actions

Given what has been observed in Europe on the disease, targeted communication was quickly implemented towards MSM people. The sexosafe.fr site, dedicated to the sexuality of MSM people, is regularly updated with a summary of knowledge on the subject and preventive measures. The messages recalling the symptoms and what to do in the event of symptoms were relayed via a digital campaign. Since June 17, the digital campaign has generated nearly 622,565 clicks on the banners and more than 491,314 visits to the Sexosafe site.
This device was supplemented with a poster campaign in places of conviviality with nearly 1,350 poster spaces. And for a few weeks by broadcasting spots on community radios. At the same time, posters, flyers and advice sheets were distributed thanks to associations, ARS and Sexosafe teams present in the field, as part of pride marches and in MSM meeting places. To date, 2,842 posters and 94,400 flyers have been ordered.
A digital campaign on preventive vaccination began on July 25 and tools for the field will also be made available in the coming days, following the publication of the opinion of the High Authority for Health on July 07 .
Prevention actions are continuously adapted to the evolution of the situation and the state of knowledge.

• Access documents

To facilitate access to information for vulnerable people in precarious situations, a pictorial tool, translated into 6 languages, developed with professionals working with these people is available on Santé Publique France .
The MOBCO newsletter n°7 compiled with actors in the field brings together a series of questions/answers on the subject of Monkeypox/monkey pox. It is aimed at professionals or volunteers in contact with people in precarious situations.

• Subscribe

Monkeypox info service: a listening device to answer questions about monkeypox

Since Wednesday, July 13, a listening device has been open to answer questions raised by monkeypox. Subsidized by Public Health France and carried by SIS Association, the “Monkeypox info service” telephone line is accessible every day from 8 a.m. to 11 p.m., on the toll-free number 0 801 90 80 69 (free, anonymous and confidential call and services). This system is in charge of accompanying prevention messages and protective measures, of providing information on symptoms, treatments and vaccination, of advising and of directing people to treatment systems.
Since the line opened, 5,007 interviews have been carried out on Monkeypox info service (median age: 39).

• 1,328 interviews were carried out in week 31 (versus 1,647 the previous week)
• 58% of calls come from Île-de-France (and mostly from Paris)
• As in previous weeks, the 25-39 age group remains in the majority among callers, but there is an increase in the proportion of people over 55 (19% of interviews vs 16% the previous week) and in that of under 25 (9% vs. 7%)
• Emergence of calls from healthcare professionals asking for help to obtain information and better guide their patients diagnosed positive for monkeypox (2% of calls in week 31)
• In order of importance, the interviews always primarily concern means of prevention (66% of interviews) and more particularly access to vaccination and the difficulties encountered by callers in obtaining an appointment, then general issues. psychological and relational (22% of interviews), and symptoms (21%)

Preventive vaccination against monkeypox

Faced with the spread of the Monkeypox virus (monkey pox), the High Authority for Health, seized by the Directorate General for Health, recommended in its opinion of July 7, 2022 that preventive vaccination be offered to the groups most exposed to the virus. .
Regarding the deployment of vaccination, 54,585 doses of 3rd generation vaccine were delivered by the Agency to the territories on 08/09/2022.
Since July 11, 2022, in addition to people who have had risky contact with a sick person, people falling within the indications retained by the HAS can make an appointment to be vaccinated throughout France:

• Men who have sex with men reporting multiple sex partners.
• Trans people reporting multiple sex partners.
• sex workers.
• Professionals working in places of sexual consumption.

Vaccination can also be considered on a case-by-case basis for health professionals who have to take care of sick people.
For more information on vaccination and access to vaccination sites:

• https://www.sante.fr/monkeypox
• https://www.sexosafe.fr/Variole-du-singe
• https://vaccination-info-service.fr/Les- Maladies-et-leurs-vaccins/Variole-du-singe-Monkeypox
• https://www.iledefrance.ars.sante.fr...-ile-de-france

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