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  • Egypt: Viral mutations

    Viral mutations



    The WHO is continuing to warn against the threat posed by Avian Flu. But is anyone listening?
    <hr noshade="noshade"> <!-- STORY --> The World Health Organisation (WHO) has issued a series of alerts, many specifically directed at developing countries, warning about the ongoing danger posed by the prevalence of Avian Flu, reports Reem Leila. The warnings coincide with a WHO report revealing that in Vietnam Avian Flu has moved one step closer towards mutating into a strain capable of human to human transmission. However, Egyptian Health Ministry official spokesman, Abdel-Rahman Shahin, disagrees with the report saying the Vietnam mutation "was a result of tests conducted by Vietnamese scientists on a limited number of poultry".
    According to Zuheir Hallaj, WHO representative and director of communicable disease control, the world remains at high risk from a potential H5N1 pandemic. Egypt, together with other countries which have seen major outbreaks of the disease, is under increasing pressure from the international community to control the spread of the virus among poultry. Hallaj believes that the only way to end the flu virus is to prevent any direct contact between humans and the virus. "People must stop dealing, directly or indirectly, with infected birds," he argues.

    Despite the limitations of existing models they all indicate, according to Shahin, that national health systems will be able to cope with any potential morbidity and mortality from the disease.
    Hussein Khalafallah, head of Directorate of Veterinary Medicine (DVM), believes that while the H5N1 bird flu virus has witnessed a further mutation, developing a more virulent poultry infecting strain, it is some way from becoming capable of human to human transmission, though the changes are worrying.

    Since 2006 there have been 38 recorded cases of the H5N1 Avian Flu virus infecting humans in Egypt. Fifteen of the victims died.
    Khalafallah points out that while poultry has a body temperature of 106 degrees Fahrenheit humans have an average temperature of 98.6 degrees Fahrenheit. The nose and throat, where flu viruses usually enter, is even cooler, at 91.4 degrees Fahrenheit. "While normally bird flu has difficulty developing in the nose or throat of humans this latest mutation allows H5N1 to survive in the cooler temperatures of the human upper respiratory tract."
    Hamid Samaha, head of the General Authority for Veterinary Services at the Ministry of Agriculture, says the ongoing campaign to combat bird flu has succeeded in reducing the incidence of infection among domestic poultry, with only three sites testing positive in August.

    While bird flu has been effectively contained some cases continue among home-raised chickens, Shahin told Al-Ahram Weekly. Last week 30 birds were culled in Minya after testing positive. Samples were taken for analysis from people who had been in direct and indirect contact with the bird, none of which recorded positive results. Since the outbreak of bird flu in Egypt in February 2006, 3,645 people have been tested for Avian Flu.

    The World Bank has granted $7.14 million to Egypt to be used in implementing measures to prevent the spread of Avian Flu and in purchasing equipment necessary to detect the virus and protect health workers. Samaha notes that the financial assistance provided by the World Bank will allow Egypt to improve health security when culling and disposing of infected birds as well as training workers to deal with the virus. In addition to developing a more efficient system to report outbreaks, the funds will allow central laboratory tests in Cairo to meet international standards.

  • #2
    Re: Egypt: Viral mutations

    Thanks, AnneZ!
    Last week 30 birds were culled in Minya after testing positive. Samples were taken for analysis from people who had been in direct and indirect contact with the bird, none of which recorded positive results.
    This outbreak has not been reported anywhere on the Egyptian government's bf website:


    Nor have I seen it reported in the four Egyptian newspapers that I (now) regularly "read" daily: Masrawy, Al Masry Al Youm [Egypt Today], Al Messa [The Evening Gazette] and Al Wafd [The Delegation]. Of course, it might've been reported elsewhere, especially in a local Minya newspaper -- who knows.
    ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

    Comment


    • #3
      Re: Egypt: Viral mutations

      Originally posted by Theresa42 View Post
      Thanks, AnneZ!This outbreak has not been reported anywhere on the Egyptian government's bf website:


      Nor have I seen it reported in the four Egyptian newspapers that I (now) regularly "read" daily: Masrawy, Al Masry Al Youm [Egypt Today], Al Messa [The Evening Gazette] and Al Wafd [The Delegation]. Of course, it might've been reported elsewhere, especially in a local Minya newspaper -- who knows.
      Positives usually trump negatives, so reports of 30 backyard chickens testing positive for H5N1 are likely to be true.

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      • #4
        Re: Egypt: Viral mutations

        Originally posted by niman View Post
        Positives usually trump negatives, so reports of 30 backyard chickens testing positive for H5N1 are likely to be true.
        Absolutely. It just bugs me that the Egyptian gov't hasn't reported this on their website -- as they haven't for many, many other outbreaks either.

        Nor do they seem to have reported ANY H5N1 outbreak to the OIE since March 2006. Aaargh.

        Edit: More here >> http://www.flutrackers.com/forum/showthread.php?t=39745
        ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

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        • #5
          Re: Egypt: Viral mutations

          Originally posted by Theresa42 View Post
          Absolutely. It just bugs me that the Egyptian gov't hasn't reported this on their website -- as they haven't for many, many other outbreaks either.

          Nor do they seem to have reported ANY H5N1 outbreak to the OIE since March 2006. Aaargh.

          Edit: More here >> http://www.flutrackers.com/forum/showthread.php?t=39745
          I would not expect OIE reporting to change. There are more H5N1 patient and poultry outbreaks in Egypt than anywhere outside of Asia, and many of the H5N1 sequences have been released.

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          • #6
            Re: Egypt: Viral mutations

            Originally posted by niman View Post
            I would not expect OIE reporting to change. There are more H5N1 patient and poultry outbreaks in Egypt than anywhere outside of Asia, and many of the H5N1 sequences have been released.
            Ok. I won't hold my breath then.
            ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

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            • #7
              Re: Egypt: Viral mutations

              Perhaps in this case holding your breath Theresa is the right thing to do.
              Please do not ask me for medical advice, I am not a medical doctor.

              Avatar is a painting by Alan Pollack, titled, "Plague". I'm sure it was an accident that the plague girl happened to look almost like my twin.
              Thank you,
              Shannon Bennett

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              • #8
                Re: Egypt: Viral mutations

                Originally posted by Theresa42 View Post
                Ok. I won't hold my breath then.
                Waiting for OIE isn't a good idea, but I think you will here more about this outbreak soon.

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                • #9
                  Re: Egypt: Viral mutations

                  Originally posted by Shannon View Post
                  Perhaps in this case holding your breath Theresa is the right thing to do.
                  Ha! Can't I just ask everyone else to, please, hold their breaths instead?! [ Another ]
                  ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

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                  • #10
                    Re: Egypt: Viral mutations

                    Commentary at

                    Comment


                    • #11
                      Re: Egypt: Viral mutations

                      Originally posted by niman View Post
                      Commentary

                      H5N1 Re-emergence in Minya Egypt

                      Recombinomics Commentary
                      November 3, 2007

                      Last week 30 birds were culled in Minya after testing positive

                      The above comments suggest H5N1 has re-emerged in Egypt again. This is not a surprise. The first H5N1 reported in Africa was a healthy teal in the Nile Delta. The sample was collected in December, 2005, prior to acknowledgement by any country in the Middle East or Africa or any country in western Europe.

                      The teal in the Nile Delta was not a surprise because of the proximity to overlapping flyways and earlier reports of H5N1 in Siberia, Mongolia, and eastern European countries bordering the Black Sea.

                      The detection in December, 2005 was followed by human cases in the Middle East, including Turkey and Egypt, as well as approximately 50 countries in Europe, the Middle East, and Africa. In Egypt, after H5N1 reports declined over the summer, it re-emerged in the fall of 2006 and peaked in early 2007.

                      Thus, after a decline, a re-emergence was expected. The re-emergence was also signaled by recent reports of H5N1 in Krasnodar, which followed a large outbreak in Germany and adjacent countries over the summer.

                      The sequences of the new infections should be of interest. In 2007, the H5N1 in Egypt was more complex than early 2006. Included were isolates with changes in or near the receptor binding domain, as well as oseltamivir (Tamiflu) resistance (in the Ghabiya cluster). The M230I change adjacent to the receptor binding domain was linked to fatal infections in patients. Milder cases were reported in central and southern Egypt. The cases included sequences with a 3 PB deletion as well as a novel cleavage site previously seen in Mongolia.

                      In addition, many of the 2007 isolates had acquired NA G743A, which was appended onto multiple genetic backgrounds in Egypt, as well as 2007 isolates in Moscow and Ghana. The same acquisition by the recent Krasnodar isolate suggests that more G743A acquisitions will be found this season.

                      Moreover, the Krasnodar sequence was most closely related to earlier isolates from Mongolia and Tyva, which matches the description of the H5N1 found in wild birds and poultry in Germany this summer. These outbreaks in Germany and Krasnodar may lead to similar acquisitions in Egypt this season.


                      .
                      "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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