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Europe - 19 dead, 2000+ infected, 500 severe cases of E-coli - EHEC STEC hemolytic uremic syndrome

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  • Europe - 19 dead, 2000+ infected, 500 severe cases of E-coli - EHEC STEC hemolytic uremic syndrome

    Within a few days a rising number of acute infections with Enterohemorrhagic Escherichia coli (EHEC) have occurred in Germany, especially in the northern states of Germany (Lower Saxony and Bremen, recently Hessia as well). Enterohemorrhagic Escherichia coli (EHEC) can cause severe hemorrhagic colitis characterized by gastrointestinal symptoms and bloody diarrhea. Health officials reported a total of at least 80 persons with suspected or confirmed EHEC-infection, some of whom are treated at intensive care units because of hemolytic uremic syndrome and acute renal failure (7 patients have been admitted to the ICU of the University Hospital at L?beck on Sunday, May 22, 2011). Most of the acute infections seem to occur in female adults (EHEC-infections typically and predominantly occur in children). The source of the infection is unknown; Robert Koch-Institute is involved.


    Der hochgefährliche Ehec-Erreger breitet sich im Norden Deutschlands weiterhin schnell aus - vor allem erwachsene Frauen sind betroffen. Die Behörden suchen mit Hochdruck nach der Ursache: Inzwischen rückt Gemüse in den Fokus der Ermittler.


    22.05.2011

    EHEC-Erreger
    Zahl lebensgef?hrlicher Darminfekte im Norden steigt stark


    Der hochgef?hrliche EHEC-Erreger breitet sich im Norden Deutschlands weiterhin schnell aus - vor allem erwachsene Frauen sind betroffen. Die Beh?rden suchen mit Hochdruck nach der Ursache: Inzwischen r?ckt Gem?se in den Fokus der Ermittler.
    Hamburg/Hannover - Eine ungew?hnliche H?ufung schwerer Darminfektionen mit dem lebensgef?hrlichen EHEC-Erreger alarmiert die Gesundheitsbeh?rden in Deutschland. Mindestens 80 Menschen haben sich bislang mit dem lebensgef?hrlichen Darmbakterium infiziert, das sich schnell ausbreitet und au?ergew?hnlich schwere Krankheitsf?lle mit Nierenleiden hervorruft. Viele Patienten liegen auf Intensivstationen.
    In Niedersachsen und Bremen gibt es nach Ministeriumsangaben inzwischen jeweils fast 25 gemeldete Verdachtsf?lle, in Schleswig-Holstein und Hamburg jeweils rund 20. Hessen meldete Sonntagabend 16 Verdachtsf?lle, Mecklenburg-Vorpommern vier. Ein Gro?teil der Patienten wird in Kliniken behandelt. Allein in Bremerhaven w?rden derzeit etwa 20 F?lle behandelt, sagte ein Sprecher des nieders?chsischen Gesundheitsministeriums. Er sprach von einer "beunruhigenden H?ufung in so kurzer Zeit".
    Zu den Krankheitssymptomen geh?ren w?ssriger oder blutiger Durchfall, ?belkeit, Erbrechen und Bauchschmerzen. Als m?gliche Komplikation kommt es zu Nierenversagen, das zum Tod f?hren kann. Ein Sprecher des nieders?chsischen Sozialministeriums rief dazu auf, bei Symptomen sofort zu reagieren und zum Arzt zu gehen.
    Experten empfehlen gr?ndliche Hygiene in der K?che
    Gesundheitsexperten suchen unter Hochdruck nach der Quelle des Krankheitserregers. "Wir haben eindeutig eine ungew?hnliche Situation", sagte Epidemiologe G?rard Krause vom Robert Koch-Institut (RKI) in Berlin. Mittlerweile gehen die Experten davon aus, dass die Erreger durch ungewaschenes Gem?se oder Obst ?bertragen wurden. Zuerst hatten sie vor allem Rohmilch und Rindfleisch im Visier - das EHEC-Bakterium befindet sich oftmals im Kot von Nutztieren.
    Einen Hinweis auf Gem?se oder Obst als m?gliche ?bertr?ger sehen die Wissenschaftler darin, dass diesmal ?berraschenderweise besonders Frauen betroffen sind: "Die Frauen bereiten h?ufiger Lebensmittel zu, und da k?nnen sie sich m?glicherweise bei der Reinigung des Gem?ses oder anderer Lebensmittel infizieren", sagte RKI-Experte Krause. Das RKI empfiehlt, auch bei der Verarbeitung von Gem?se auf gute K?chenhygiene zu achten sowie Bretter und Messer gr?ndlich zu reinigen.
    Nach Angaben aus dem nieders?chsischen Sozialministerium ist noch unklar, ob es ?berhaupt einen gemeinsamen Erreger gibt. Experten vermuten dies. "Der Hauptanhaltspunkt ist das gemeinsame zeitliche Auftreten der F?lle", sagte ein Ministeriumssprecher. Die Ermittlung der Quelle f?r die Erkrankungen gestaltet sich nach Angaben des nieders?chsischen Ministeriums auch deswegen schwierig, weil die Erkrankten detailliert dazu befragt werden m?ssen, was sie in den letzten Tagen gegessen haben. Viele Patienten seien aber so schwer erkrankt, dass solche Befragungen gar nicht m?glich sind.
    EHEC-Keime (Enteroh?morrhagische Escherichia coli) treten in Deutschland immer wieder auf. Das RKI hat seit Einf?hrung der Meldepflicht 2001 bundesweit j?hrlich 800 bis 1200 Erkrankungen registriert, die aber oft einen leichteren Verlauf nahmen.

  • #2
    Germany - Super-bug (E.Coli sub-strain - EHEC) kills 3 - 400+ cases

    Source: http://www.timeslive.co.za/scitech/a...s-first-German

    Super-bug kills first German
    May 24, 2011 12:55 PM | By Sapa

    Germany reported its first death from a virulent super-bacterium that has spread through the north of the country in just a week, possibly via fresh produce sold in supermarkets.

    Hundreds of people have fallen gravely ill from the new sub-strain of E. coli. It causes internal bleeding, diarrhoea and kidney failure and is partly resistant to antibiotics, scientists said.

    An 83-year-old woman died of her infection in a hospital at Diepholz near Hanover, state health officials said. She was admitted to hospital in "mid-May." Lab tests showed she had enterohaemorrhagic Escherichia coli (EHEC), a dangerous form of E. coli.

    A second death, of a young woman in a hospital at Bremen, may have been caused by EHEC, officials said as lab tests were under way...

    Comment


    • #3
      Re: Super-bug (E.Coli sub-strain) kills first German

      May 24, 2011

      INTESTINAL GERM EHEC

      Diarrheal pathogen spreads rapidly

      In northern Germany, the EHEC suspected cases have doubled in one day. Two infected female pensioners were killed, the death of a young woman is being investigated.

      The dangerous diarrhea germ Ehec seems to have killed so far three people.

      One of the victims, a 83-year-old woman from Lower Saxony, had been hospitalized since mid-May because of bloody diarrhea, said the health ministry in Hanover.

      The laboratory evidence has shown an EHEC infection. In Bremen, died, according to the Health Authority, a young woman who had bloody diarrhea - a typical symptom after such an infection. The finding of a laboratory test is still pending, it said.

      - snip -

      Nationwide, the competent authorities were far more than 400 suspected cases and cases of illness. Alone in Schleswig-Holstein, the number had doubled, according to the State Health Department within one day to more than 200. "This development exceeds any historic measure," said the microbiologist Werner Solbach, University Hospital Schleswig-Holstein.

      Caused by the intestinal bacterial disease often heavy and is accompanied by renal failure, it said. Many patients had to intensive care units. Professionals of the health authorities and researchers are still looking for the cause of the infectious disease.

      More: Zeitonline

      Comment


      • #4
        Re: Super-bug (E.Coli sub-strain) kills first German - 2 more suspect deaths - 400 cases

        May 24, 2011

        Canteens closed, employees will be investigated

        The EHEC pathogen spreads further in Germany . The Robert Koch Institute, calls the number of patients alarming .

        Some snips from the article:


        "There is speculation that EHEC pathogens had been sprayed on manure on the vegetables. It is totally absurd, vegetables fertilized with manure," said the spokesman for the Chamber of Agriculture of North Rhine-Westphalia, Bernard Rüb.

        -----------------------

        The Robert Koch Institute (RKI) sees a "frightening" spread of dangerous intestinal bacteria EHEC in Germany. In the past few days more than 80 patients with a severe course been registered with kidney damage, said President Reinhard Burger Robert Koch Institute.

        This was "shocking many." That number are infected with the so-called HUS syndrome will usually be achieved within one year. Nor is it apparent that this development will be declining.

        -----------------------

        After the outbreak of EHEC pathogen in Germany the first with the dangerous intestinal germ infected people died: on Tuesday, two known deaths. A third victim was suspected of infection. However, it was unclear whether the intestinal infection in fact was the cause of death among the three women.

        welt.de

        Comment


        • #5
          Re: Super-bug (E.Coli sub-strain - EHEC) kills first German - 2 more suspect deaths - 400 cases

          Welt Online - LIVE-TICKER EHEC (German)

          17:05 The Numbers of EHEC infections rose again

          A survey by the news agency DPA showed there have been more than 460 confirmed and suspected cases. In Schleswig-Holstein the authorities recorded particularly large quantity of EHEC patients. There are about 100 people are infected with the virus, twice as many samples are still under consideration. "This development exceeds any historic measure," said the microbiologist Professor Werner Solbach, University Hospital Schleswig-Holstein.


          16.53 RKI-President warns of more deaths

          After the outbreak of the intestinal bacterium EHEC the Robert Koch Institute (RKI) expects other victims. So far, more than 80 were called HUS cases are known, "said Reinhard Burger Robert Koch Institute president. This hemolytic-uremic syndrome is the most serious complication of infection. "We must say clearly that we must reckon with more death," said Burger. The source of infection is still unknown.

          Comment


          • #6
            Re: Super-bug (E.Coli sub-strain - EHEC) kills first German - 2 more suspect deaths - 400 cases

            Translation Google

            Epidemie in Germania. Epidemic in Germany. A contagious bacteria killed two people.

            19:20, 24 Mai 2011 7:20 p.m., May 24, 2011 , Stirile Pro TV , Pro TV News

            Health authorities in Germany trying to discover the source of an outbreak of infection with the bacteria E-coli. There are already two dead, one patient in a coma and hundreds of other cases of illness. Many so severe that dialysis is needed.

            In many cases, patients went straight to intensive care and doctors expect the number of admittances to grow, as E-coli bacteria infection in an aggressive form, is contagious.

            There is an intestinal virus again, but what is exceptional in this epidemic is "large number of serious cases," said experts.

            "When the disease is discovered too late, then the therapy does not give any results, even dialysis," says Dr. Jan Kielstein, specilist dialysis at a hospital in Hanover.

            "It is important to identify the cause of these diseases in the table with a severe evolution. I still do not know when we will be able to find the causes," said Thomas Spieker, an expert in the Ministry of Health.

            Most of the sick are women, and experts say that inadequate washing raw vegetables and spread infection among housewives who prepare meals for their families. And unpasteurized milk or raw meat may be contaminated with E-coli battery.

            "Especially for those with low immunity, the disease can be fatal. Also, outcome may be fatal in children," warns Susanne Glasmacher, Robert-Koch Institute expert.

            Comment


            • #7
              Re: Super-bug (E.Coli sub-strain - EHEC) kills first German - 2 more suspect deaths - 400 cases

              Critical hours for E. coli outbreak in Germany - May 24, 2011

              Posted on behalf of Marian Turner

              The next 24 hours will be critical for scientists in Germany who are trying to understand if an outbreak of infections from a deadly strain of E. coli currently sweeping the country is a severe instance of a normal infection, or something different.

              Three women have died today from suspected infections with the bacteria enterohaemorrhagic Escherichia coli (EHEC) which causes dysentery-like, bloody diarrhoea, severe cramping and fever. Health authorities have registered a further 400 confirmed cases ? mostly young women. First cases emerged barely two weeks ago and authorities have been shocked at the rate at which this outbreak has spread.

              At least a hundred patients are being treated in hospital. The Robert Koch Institute, the national institute responsible for disease control, confirmed this morning that 80 patients with EHEC infection had gone on to develop the life-threatening haemolytic uraemic syndrome (HUS), which can lead to acute kidney failure.

              Today?s deaths were of two women in their 80s ? one of these has already been confirmed as an EHEC case - and one young woman.

              More...

              Comment


              • #8
                Re: Super-bug (E.Coli sub-strain - EHEC) kills first German - 2 more suspect deaths - 400 cases

                E. coli O104 cause of German outbreak; 3 dead, over 400 sick; fresh produce suspected

                Posted: May 24th, 2011 - 2:19pm by Doug Powell

                Klaus Stark, group leader of gastrointestinal infections and zoonotic diseases at the Robert Koch Institute (RKI) told Der Tagesspiegel that E. coli O104 appears to be the cause of an E. coli epidemic sweeping Germany, with at least three dead, over 400 sick including 80 cases of hemolytic uremic syndrome.

                "It looks right now like it is a type EHEC O104 cause of the disease."

                More...

                Comment


                • #9
                  Re: Rising number of acute EHEC-infections in Germany (May 22, 2011)

                  update (May 25, 2011):
                  3 deaths (at least one definitively confirmed by health officials: EHEC), over 400 sick including 80 cases of hemolytic uremic syndrome




                  Quote (Posted: May 24th, 2011 - 2:19pm by Doug Powell):

                  "Klaus Stark, group leader of gastrointestinal infections and zoonotic diseases at the Robert Koch Institute (RKI) told Der Tagesspiegel that E. coli O104 appears to be the cause of an E. coli epidemic sweeping Germany, with at least three dead, over 400 sick including 80 cases of hemolytic uremic syndrome."

                  additional link (German language only):
                  Von Tür zu Tür: Wie Seuchenexperten versuchen, die Quelle der EHEC-Infektion ausfindig zu machen. Einen ersten Hinweis gibt es in Frankfurt am Main.

                  Comment


                  • #10
                    Re: Germany - Super-bug (E.Coli sub-strain - EHEC) kills 3 - 400+ cases

                    From Robert Koch Institut (= German CDC)

                    Accumulation of life-threatening, hemolytic-uremic syndrome (HUS), caused by bacteria

                    Update 25.05.2011, 12:00

                    Since the second week of May more people are ill from bloody diarrhea and the so-called
                    hemolytic-uremic syndrome (HUS). The cases occurred mainly in northern Germany,
                    There are also preliminary reports from southern and eastern Germany.

                    The Robert Koch Institute has confirmed to the evening of May 24, 2011, approximately 140 cases of HUS,
                    including 3 deaths. The number of severe cases in a short period is very
                    unusual , also the affected age groups are not typical.

                    We have mainly adults, mostly women, are affected. Usually
                    mainly children developed this serious disease: In 2010, for example, the Robert Koch Institute confirmed 65 cases of HUS, 6 affected were older than 18 years.

                    The HUS is a severe and sometimes fatal complication in bacterial
                    intestinal infections which can occur with so-called enterohemorrhagic Escherichia coli (EHEC).
                    Each year, the Robert Koch Institute confirms about 1,000 cases of EHEC. The full picture of HUS is characterized
                    by acute renal failure, anemia in red blood cells by the decay and lack of
                    platelets. In 2010, the Robert Koch Institute cofirmed two deaths.

                    Read more - RKI

                    Comment


                    • #11
                      Re: Germany - Super-bug (E.Coli sub-strain - EHEC) kills 3 - 400+ cases

                      Snip from BBC news:

                      A Reuters news agency report suggests that the infection may be spread through contaminated vegetables, and the high number of affected young women points to a product more often bought or prepared by women.

                      Susan Huggett of the Medilys laboratories in Hamburg advised against eating pre-packaged or prepared salad, which might contain the bacterium.

                      She also recommended standard hygienic procedures such as washing hands before eating or cooking.

                      See also: http://www.flutrackers.com/forum/sho...02&postcount=3

                      Comment


                      • #12
                        Re: Rising number of acute EHEC-infections in Germany (May 22, 2011)

                        I merged 2 threads on this topic. The URL that is working for this thread is the one that started with german-docter's first post.

                        Thank you everyone.

                        Comment


                        • #13
                          Re: Rising number of acute EHEC-infections in Germany (May 22, 2011)

                          [Source: European Centre for Disease Prevention and Control (ECDC), full page: (LINK).]
                          Outbreak of Shiga toxin-producing E. coli in Germany



                          25 May 2011

                          Outbreak of Shiga toxin-producing E. coli in Germany
                          Epidemiological update, 25 May 2011


                          On 22 May, Germany reported a significant increase in the number of patients with haemolytic uremic syndrome (HUS) and bloody diarrhoea caused by Shiga toxin-producing E. coli (STEC).

                          Since the end of April, 138 cases of HUS have been reported.

                          While HUS, caused by STEC infections, is usually observed in children under 5 years of age, in this outbreak the great majority of cases are adults, with more than two thirds being women.

                          Two of the HUS cases have died. Preliminary diagnostic investigations indicate that serogroup O104 (Stx2-positve, eae-negative) might be the causative agent.

                          The source of the outbreak is under investigation, but contaminated food seems the most likely vehicle of infection. There is currently no indication that raw milk or meat is associated with the outbreak.

                          Most cases are from, or have a history of travel to the North of Germany (mainly Hamburg, Northern Lower Saxony, Mecklenburg-Western Pomerania).

                          Sweden is currently the only EU Member State reporting an unusual increase of STEC and HUS cases, and probable links with Germany are being investigated.

                          To date, this non-O157 STEC outbreak is limited to Germany, and there is no evidence that there is a risk for infection outside of the country.

                          Identification of the vehicle of infection will further determine the assessment of this risk. Rapid identification of potential cases linked to this outbreak, within Germany or among persons who have travelled to Germany since the beginning of May, is essential to prevent the development of severe disease.
                          STEC is a group of pathogenic Escherichia coli (E. coli) strains capable of producing Shiga toxins, with the potential to cause severe enteric and systemic disease in humans.

                          - -------

                          Comment


                          • #14
                            Re: Rising number of acute EHEC-infections in Germany (May 22, 2011)

                            Deutsche Welle May 26, 2011:

                            The German authorities have identified cucumbers from Spain as the source of a recent E. coli outbreak in northern Germany that has killed several. Germans have been advised not to eat cucumbers for the time being.



                            Germans told to avoid some vegetables in E.coli [EHEC] outbreak

                            Author: Mark Hallam (dapd, dpa, Reuters)

                            A German health organization says it's 'highly probable' that the recent spate of E.coli infections in Germany will be traced back to eating raw salads, tomatoes and cucumbers - possibly from northern Germany.

                            The precise cause of an outbreak of poisoning by the dangerous E.coli bacteria in Germany remains unclear, but the Robert Koch Institute - responsible for the monitoring of diseases and their prevention on behalf of the German government - said on Wednesday that raw vegetables and tomatoes from Northern Germany were strong candidates.
                            (?)
                            An 89-year-old woman in the northernmost state of Schleswig-Holstein, who passed away on Wednesday, was thought to be the second EHEC death, according to preliminary information from the state health ministry. Three other possible EHEC fatalities were being investigated elsewhere in the country. Authorities confirmed on Tuesday that an 83-year-old woman died of EHEC infection near Hanover.
                            (?)
                            One popular theory for the contamination is that farmers might have sprayed contaminated dung on their produce, possibly explaining the unusual vegetable source of the infection.
                            (?)

                            Comment


                            • #15
                              Re: Rising number of acute EHEC-infections in Germany (May 22, 2011)

                              From Gothenburg , Sweden - Machine translation

                              Thursday 26 May 2011

                              "I feel terrible"

                              Twelve golf travelers from the town have fallen ill with bowel disease EHEC in connection with a trip to northern Germany. Seriously ill.

                              On the trip, organized by Alingsås Golf Club were 30 passengers. They left Sweden for a couple weeks ago to play golf for four days in a small town outside Hamburg. Barely a week after returning home the first of them were hit with bloody diarrhea in what would later turn out to be bowel disease EHEC.

                              - I have never experienced anything similar. I am exhausted and still feel terribly bad, said Lena Broberg from a hospital bed in East Infection Clinic in Gothenburg.

                              GP.SE

                              Comment

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