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  • Two more Indonesians have bird flu

    Two more Indonesians have bird flu
    Tue Feb 6, 2007 7:56am ET
    By Achmad Sukarsono

    JAKARTA (Reuters) - Two more Indonesians were confirmed to have bird flu on Tuesday and Pakistan reported its first case in a year after finding the deadly virus in a small flock of chickens near the capital Islamabad.

    Concern has grown since the H5N1 virus flared again in Asia in recent months, spreading through poultry flocks in South Korea, Japan, Thailand and Vietnam.

    The H5N1 virus has spread into the Middle East, Africa and Europe since it reemerged in Asia in 2003 and outbreaks have now been detected in birds in around 50 countries.

    On Monday, Britain killed 160,000 turkeys following the discovery of bird flu on a turkey farm in eastern England. South Korea and Hong Kong on Tuesday joined Japan and Russia in banning British poultry.

    In Indonesia, which has the highest human bird flu death toll, the latest human case was a girl from an upscale Jakarta neighborhood who had caught a wild bird which died two days later, Joko Suyono of the health ministry's bird flu center said.

    The other was a West Java man who lived in an area where many poultry had died.

    Indonesia, where many people keep chickens in their backyards, has had 63 human deaths from the highly pathogenic H5N1 bird flu virus, six of them this year.

    The government has stepped up efforts to stamp out the virus which is endemic in poultry in most of the provinces in the country of 17,000 islands where most bird flu victims have caught the disease from contact with infected fowl.

    "CONTAINED"

    In Pakistan, Mohammad Afzal, Livestock Commissioner at the Ministry of Agriculture, said all the chickens in the flock of about 40 birds at a house in Rawalpindi, a city adjoining Islamabad, had died or been culled as a result of H5N1.

    "It has been contained and there is no danger of the spread of this virus because there are no poultry farms near this house," he told Reuters.

    Pakistan's first reported cases of H5N1 bird flu were found in chickens in February last year in North West Frontier Province. In all, about 40,000 chickens were culled. There have been no human cases in Pakistan.

    The two new Indonesian cases came as Jakarta said it had stopped sharing human genetic samples of the most deadly strain of bird flu with foreign laboratories because it wanted to keep control of the intellectual property rights of the H5N1 strain.

    "We can't share samples for free. There should be rules of the game for it," said the health ministry's spokeswoman, Lily Sulistyowati.

    "Just imagine they could research, use and patent the Indonesia strain. We can't give the samples but we can share data in the gene bank."

    Sulistyowati said Indonesia would sign a Memorandum of Understanding with U.S. medical products maker Baxter International on Wednesday to collaborate on making a human bird flu vaccine.

    "The vaccine is to prevent poultry-to-human infection. That's what we need for the current situation and not for the future pandemic," she said.

    Baxter confirmed it expected to conclude a "framework for future collaboration" with Indonesia this week, but said it would still abide by World Health Organization rules on sharing virus samples, the Financial Times newspaper said.

    No comment was immediately available from Baxter.

    (Additional reporting by Mita Valina Liem in JAKARTA, Kang Shinye in Seoul and Nao Nakanishi in HONG KONG)

    ? Reuters 2007. All Rights Reserved.

  • #2
    Re: Two more Indonesians have bird flu

    Bird Flu Kills Egyptian Girl, Infects Two Indonesians (Update1)

    By Karima Anjani and Dania Saadi

    Feb. 6 (Bloomberg) -- Bird flu killed an Egyptian girl and infected two more people in Indonesia. The virus also reemerged in poultry in Russia and may have killed a woman in Azerbaijan.

    The H5N1 strain of avian influenza has resurfaced in the U.K., Japan and at least seven other countries in Asia, Europe and Africa the past two months, increasing the risk of human infection and providing chances for the virus to mutate into a pandemic form.

    In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.

    ``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.

    The H5N1 virus is known to have infected 271 people in 11 countries, killing 165 of them, since 2003, the World Health Organization estimates. The virus is a threat mainly to birds at the moment, though it may mutate and gain the ability to spread between people, experts say.

    Indonesia, the world's fourth-most-populous country, has recorded 63 fatalities, 21 more than any other nation. The other patient confirmed today to have tested positive for the H5N1 virus was hospitalized in the city of Bandung in West Java province, Suyono said.

    Pandemic Vaccines

    The disease entered the U.K. earlier this week when turkeys died at a farm in Suffolk, prompting tighter security measures across Europe.

    ``The events in recent weeks, especially outbreaks in the U.K. and Hungary, call for even more vigilance,'' French Prime Minister Dominique de Villepin said in a statement today.

    More than a dozen drug companies worldwide are using H5N1 as the basis for vaccines that would protect people from a pandemic sparked by the virus.

    Indonesia wants vaccine makers to seek permission to use viruses collected there to secure access to the shots produced, said Triono Soendoro, director-general of the National Institute of Health Research and Development.

    ``What we want to avoid happening is being in a position of not being able to afford to buy the vaccines made from our own strain,'' Soendoro said in an interview today. If a pandemic occurs, ``we have to give shots to the poor and the government has to pay that cost. It will be a burden on our budget.''

    Egyptian Case

    The Indonesian government decided Dec. 20 to restrict access to its live H5N1 viruses after Melbourne-based CSL Ltd. began developing a vaccine based on material collected from an Indonesian patient. Indonesian officials now want companies to sign a so-called material transfer agreement before specimens are released, Soendoro said.

    Egypt's health ministry said a 17-year-old girl who died Feb. 4 in the southern province of Fayoum, about 100 kilometers (62 miles) south of Cairo, was the country's 20th human H5N1 case and 12th fatality.

    Health authorities weren't able to give her Roche Holding AG's Tamiflu antiviral medicine before she died, ministry spokeswoman Sayid Abbas said over the telephone today.

    Tests in Russia

    In Russia, the virus killed 45 domestic poultry on farms in Krasnodar territory, Itar-Tass said yesterday, citing Irina Voronkova, an adviser to the head of the regional consumer rights protection agency.

    The H5N1 infections are the first in the southern territory this year, the report said. In 2006, more than 300,000 birds died of the virus on one poultry farm, it said.

    Tests for the virus are being run on a 38-year-old woman from Azerbaijan's Neftchala region who died late yesterday, the Azeri-Press Information Agency said.

    The woman died at the Scientific Institute of Lung Diseases after being hospitalized on Feb. 2 with pneumonia, the news agency reported on its Web site, citing Khayyam Amado, the institute's head physician.

    A survey by state veterinary service officials on Feb. 3 found no mass poultry deaths suggestive of avian flu in the village where the woman lived, it said. Poultry samples were sent to the Republic Veterinary Laboratory for testing and results will be reported soon, the news agency said.

    To contact the reporter on this story: Karima Anjani in Jakarta at

    Comment


    • #3
      Re: Two more Indonesians have bird flu

      Commentary at

      Comment


      • #4
        Re: Two more Indonesians have bird flu

        Originally posted by niman View Post
        Commentary

        Wild Bird Linkage with H5N1 Positive Case in Jakarta
        Recombinomics Commentary
        February 6, 2007


        In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.

        ``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.

        The above comments provide a link between a confirmed H5N1 case (15F) in Jakarta with a wild bird. The girl lived in an upscale neighborhood in Jakarta, and the failure to link the case to domestic poultry is similar to the circumstances surrounding first H5N1 cluster in Tangerang, adjacent to Jakarta.

        The initial case in July, 2005 involved H5N1 with a novel cleavage site, RESRRKKR. In all but one human isolate on Java, including sequences reported for this year, the same cleavage site has been reported. Attempts to link this novel cleavage site and associated changes in all 8 gene segments has had limited success.

        Last fall 91 H5N1 positive poultry samples were sent to a WHO affiliated lab in Australia. Approximately 50 sequences were made public, and only three had the novel cleavage site. Two were from chickens on Sumatra. The only bird sample from Java was from a duck in Indramayu, isolated a year ago. However, this sequence was similar to a small subset of human cases. The vast majority of human isolates, include those from Indramayu, were distinct. Those sequences matched each other, as well as a cat sequence from Indramayu.

        The failure to match the human sequences to additional bird isolates is likely linked to limited testing of other sources of H5N1. Recent media reports describe H5N1 sequences or antibodies in dogs and cats in Bali. H5N1 sequences from wild birds in Indonesia have not been reported.

        Thus, although human H5N1 sequences have been reported in Indonesia since July, 2005, there have been no matches between a human isolate and a nearby bird isolate, although the death of nearby poultry is frequently cited in WHO updates on confirmed human cases.

        The isolation and sequencing of H5N1 from wild birds in Indonesia would be useful.

        .
        "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

        Comment


        • #5
          Indonesia reports 2 more people down with bird flu

          Can someone verify if these are in fact *new* or is this just a delayed report?

          Indonesia reports 2 more people down with bird flu
          Thursday, February, 8 2007

          JAKARTA: Two more Indonesians have been positively diagnosed with bird flu, but both are still alive, Health Minister Siti Fadillah Supari said Wednesday.

          ?Presently there is an addition of two more cases so that the total currently stands at 83 infected, 63 of them dead,? Supari told journalists at her office.

          Indonesia is the country worst affected by the deadly H5N1 strain of avian influenza, and has seen the worst of a recent resurgence of the virus, with outbreaks in poultry in Vietnam, Thailand, South Korea and Japan.

          China reported its first human case in six months in January and Egypt recorded its 11th death.

          Supari gave no details on the identity or origin of the two new Indonesian patients or whether they had a recent history of close contact with infected birds or poultry.

          But she said both were alive, even describing one as ?very much healthy.?

          The vast majority of bird-flu cases in Indonesia have stemmed from contact with infected poultry.

          According to the World Health Organization, a total of 166 people have died of bird flu since 2003, out of 272 infections.

          Scientists fear bird flu will mutate into a form easily transmissible between humans, sparking a pandemic that could potentially kill millions.

          Comment


          • #6
            Re: Two more Indonesians have bird flu

            These two individuals are most likely those mentioned in the above posts. The February 3, 2007, WHO table of cumulative cases shows 81 cases with 63 deaths in Indonesia. The people discussed above would be numbers 82 and 83, as suggested by quote from the Health Minister.

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