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Science. Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine (Science, Abstract, edited)
[Source: Science, (LINK). Abstract, edited.]
Science 18 June 2010: Vol. 328. no. 5985, p. 1529
DOI: 10.1126/science.1189132
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
D. Vijaykrishna,1,2,*, L. L. M. Poon,1,* H. C. Zhu,1,2 S. K. Ma,1 O. T. W. Li,1 C. L. Cheung,1 G. J. D. Smith,1,2,J. S. M. Peiris,1, Y. Guan1,2,
The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.
1 State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
2 International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong 515031, China.
* These authors contributed equally to this work.
Present address: Duke-NUS Graduate Medical School, Singapore.
To whom correspondence should be addressed. E-mail: malik@hkucc.hku.hk (J.S.M.P.); yguan@hkucc.hku.hk (Y.G.)
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[Source: Science, (LINK). Abstract, edited.]
Science 18 June 2010: Vol. 328. no. 5985, p. 1529
DOI: 10.1126/science.1189132
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
D. Vijaykrishna,1,2,*, L. L. M. Poon,1,* H. C. Zhu,1,2 S. K. Ma,1 O. T. W. Li,1 C. L. Cheung,1 G. J. D. Smith,1,2,J. S. M. Peiris,1, Y. Guan1,2,
The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.
1 State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
2 International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong 515031, China.
* These authors contributed equally to this work.
Present address: Duke-NUS Graduate Medical School, Singapore.
To whom correspondence should be addressed. E-mail: malik@hkucc.hku.hk (J.S.M.P.); yguan@hkucc.hku.hk (Y.G.)
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