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J VIrol. Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models
[Source: Journal of Virology, full page: (LINK). Abstract, edited.]
Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models
Jurre Y. Siegers a, Kirsty R. Short a, Lonneke M.E. Leijten a, Miranda de Graaf a, Monique I.J. Spronken a, Eefje J.A. Schrauwen a, Nicolle Marshall b, Anice C. Lowen b, G?lsah Gabriel c, Albert D.M.E Osterhaus a, Thijs Kuiken a and Debby van Riel a#
Author Affiliations: <SUP>a</SUP> Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands <SUP>b</SUP> Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA <SUP>c</SUP> Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
Published ahead of print 29 January 2014, doi: 10.1128/JVI.03190-13 <CITE>JVI.03190-13 </CITE>
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<CITE></CITE>ABSTRACT
We determined the attachment pattern of avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs and guinea pigs, and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This knowledge contributes to our knowledge on the different animal models for influenza.
FOOTNOTES
#Address correspondence to Debby van Riel, d.vanriel@erasmusmc.nl
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
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Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models
Jurre Y. Siegers a, Kirsty R. Short a, Lonneke M.E. Leijten a, Miranda de Graaf a, Monique I.J. Spronken a, Eefje J.A. Schrauwen a, Nicolle Marshall b, Anice C. Lowen b, G?lsah Gabriel c, Albert D.M.E Osterhaus a, Thijs Kuiken a and Debby van Riel a#
Author Affiliations: <SUP>a</SUP> Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands <SUP>b</SUP> Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA <SUP>c</SUP> Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
Published ahead of print 29 January 2014, doi: 10.1128/JVI.03190-13 <CITE>JVI.03190-13 </CITE>
<CITE></CITE>
<CITE></CITE>
<CITE></CITE>ABSTRACT
We determined the attachment pattern of avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs and guinea pigs, and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This knowledge contributes to our knowledge on the different animal models for influenza.
FOOTNOTES
#Address correspondence to Debby van Riel, d.vanriel@erasmusmc.nl
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
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