Nat. Com. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

[tetano]

Nat Commun. 2014 Jan 24;5:3142. doi: 10.1038/ncomms4142.
Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus.
Cui L1, Liu D2, Shi W3, Pan J4, Qi X1, Li X5, Guo X6, Zhou M6, Li W7, Li J8, Haywood J9, Xiao H10, Yu X8, Pu X8, Wu Y9, Yu H6, Zhao K6, Zhu Y6, Wu B6, Jin T11, Shi Z6, Tang F6, Zhu F6, Sun Q7, Wu L7, Yang R12, Yan J9, Lei F13, Zhu B9, Liu W9, Ma J7, Wang H6, Gao GF14.
Author information
Abstract

Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment.

PMID:
24457975
[PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24457975

[Giuseppe]

Re: Nat. Com. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

[Source: Nature Communication, full page: (LINK). Abstract, edited.]


Nat Commun. 2014 Jan 24;5:3142. doi: 10.1038/ncomms4142.

Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus.

Cui L<SUP>1</SUP>, Liu D<SUP>2</SUP>, Shi W<SUP>3</SUP>, Pan J<SUP>4</SUP>, Qi X<SUP>1</SUP>, Li X<SUP>5</SUP>, Guo X<SUP>6</SUP>, Zhou M<SUP>6</SUP>, Li W<SUP>7</SUP>, Li J<SUP>8</SUP>, Haywood J<SUP>9</SUP>, Xiao H<SUP>10</SUP>, Yu X<SUP>8</SUP>, Pu X<SUP>8</SUP>, Wu Y<SUP>9</SUP>, Yu H<SUP>6</SUP>, Zhao K<SUP>6</SUP>, Zhu Y<SUP>6</SUP>, Wu B<SUP>6</SUP>, Jin T<SUP>11</SUP>, Shi Z<SUP>6</SUP>, Tang F<SUP>6</SUP>, Zhu F<SUP>6</SUP>, Sun Q<SUP>7</SUP>, Wu L<SUP>7</SUP>, Yang R<SUP>12</SUP>, Yan J<SUP>9</SUP>, Lei F<SUP>13</SUP>, Zhu B<SUP>9</SUP>, Liu W<SUP>9</SUP>, Ma J<SUP>7</SUP>, Wang H<SUP>6</SUP>, Gao GF<SUP>14</SUP>.

Author information: <SUP>1</SUP>1] Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Province, China [2]. <SUP>2</SUP>1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China [2] Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China [3]. <SUP>3</SUP>1] School of Basic Medical Sciences, Taishan Medical College, Shandong Province, China [2] CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China [3]. <SUP>4</SUP>1] Hangzhou Center for Disease Control and Prevention, Zhejiang Province, China [2]. <SUP>5</SUP>1] Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong Province, China [2] University of Chinese Academy of Sciences, Beijing, China. <SUP>6</SUP>Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Province, China. <SUP>7</SUP>Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. <SUP>8</SUP>Hangzhou Center for Disease Control and Prevention, Zhejiang Province, China. <SUP>9</SUP>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. <SUP>10</SUP>Tianjin Institute of Biotechnology, Chinese Academy of Sciences, Tianjin, China. <SUP>11</SUP>BGI-Shenzhen, Shenzhen, Guangdong Province, China. <SUP>12</SUP>Beijing Institute of Microbiology and Epidemiology, Beijing, China. <SUP>13</SUP>CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. <SUP>14</SUP>1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China [2] University of Chinese Academy of Sciences, Beijing, China [3] Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China [4] Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.


Abstract

Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment.


PMID: 24457975 [PubMed - in process]


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