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Euro Surveill. Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013
[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]
Eurosurveillance, Volume 18, Issue 50, 12 December 2013
Research articles
Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013
A Zhang<SUP>1</SUP><SUP>,2</SUP>, Y Huang<SUP>1</SUP><SUP>,2</SUP>, D Tian<SUP>1</SUP><SUP>,2</SUP>, E H Lau<SUP>2</SUP><SUP>,3</SUP>, Y Wan<SUP>1</SUP><SUP>,2</SUP>, X Liu<SUP>1</SUP><SUP>,2</SUP>, Y Dong<SUP>1</SUP>, Z Song<SUP>1</SUP>, X Zhang<SUP>1</SUP>, J Zhang<SUP>1</SUP>, M Bao<SUP>1</SUP>, M Zhou<SUP>1</SUP>, S Yuan<SUP>1</SUP>, J Sun<SUP>1</SUP>, Z Zhu<SUP>1</SUP>, Y Hu<SUP>1</SUP>, L Chen<SUP>1</SUP>, C Y Leung<SUP>3</SUP>, J T Wu<SUP>3</SUP>, Z Zhang<SUP>1</SUP>, Xiaoyan Zhang<SUP>1</SUP><SUP>,4</SUP>, J S Peiris <SUP>3</SUP>, J Xu <SUP>1</SUP><SUP>,4</SUP>
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<SUP>1</SUP>Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China - 2 These authors equally contributed to this work - 3 School of Public Health, The University of Hong Kong, Hong Kong, China - 4 State Key Laboratory for Infectious Disease Prevention and Control, China CDC, Beijing, China
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Citation style for this article: Zhang A, Huang Y, Tian D, Lau EH, Wan Y, Liu X, Dong Y, Song Z, Zhang X, Zhang J, Bao M, Zhou M, Yuan S, Sun J, Zhu Z, Hu Y, Chen L, Leung CY, Wu JT, Zhang Z, Zhang X, Peiris JS, Xu J. Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013 . Euro Surveill. 2013;18(50):pii=20657. Available online: http://www.eurosurveillance.org/View...rticleId=20657
Date of submission: 11 November 2013
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The novel avian influenza A(H7N9) infection has recently emerged to cause severe respiratory illness in China. The objectives of this study were to define the kinetics of the antibody responses in patients with influenza A(H7N9) disease and to correlate these kinetics with clinical outcome. Serial serum samples were obtained at intervals of three to four days from 18 patients with virologically confirmed A(H7N9) disease in Shanghai. We determined the kinetics of the haemagglutination inhibition (HI) and A(H7H9) pseudotype neutralisation antibody (Nab) responses and correlated these with clinical outcomes. Most patients had robust serological responses by both HI and Nab tests. Taking into account censoring due to time of testing and death, the median time from onset of illness to Nab titre ≥1:40 was 14 days (95% confidence interval (CI): 11?18 days) in the fatal cases and 10.5 days (95% CI: 7?12) in the survivors (p=0.003). The two groups did not differ in initial Nab titres, but the rate of increase in Nab titres was significantly faster for survivors by approximately 10-fold per 15 days (p=0.007). Early and rapid induction of Nab was correlated significantly with better clinical outcome.
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Eurosurveillance, Volume 18, Issue 50, 12 December 2013
Research articles
Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013
A Zhang<SUP>1</SUP><SUP>,2</SUP>, Y Huang<SUP>1</SUP><SUP>,2</SUP>, D Tian<SUP>1</SUP><SUP>,2</SUP>, E H Lau<SUP>2</SUP><SUP>,3</SUP>, Y Wan<SUP>1</SUP><SUP>,2</SUP>, X Liu<SUP>1</SUP><SUP>,2</SUP>, Y Dong<SUP>1</SUP>, Z Song<SUP>1</SUP>, X Zhang<SUP>1</SUP>, J Zhang<SUP>1</SUP>, M Bao<SUP>1</SUP>, M Zhou<SUP>1</SUP>, S Yuan<SUP>1</SUP>, J Sun<SUP>1</SUP>, Z Zhu<SUP>1</SUP>, Y Hu<SUP>1</SUP>, L Chen<SUP>1</SUP>, C Y Leung<SUP>3</SUP>, J T Wu<SUP>3</SUP>, Z Zhang<SUP>1</SUP>, Xiaoyan Zhang<SUP>1</SUP><SUP>,4</SUP>, J S Peiris <SUP>3</SUP>, J Xu <SUP>1</SUP><SUP>,4</SUP>
<SUP></SUP>
<SUP>1</SUP>Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China - 2 These authors equally contributed to this work - 3 School of Public Health, The University of Hong Kong, Hong Kong, China - 4 State Key Laboratory for Infectious Disease Prevention and Control, China CDC, Beijing, China
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Citation style for this article: Zhang A, Huang Y, Tian D, Lau EH, Wan Y, Liu X, Dong Y, Song Z, Zhang X, Zhang J, Bao M, Zhou M, Yuan S, Sun J, Zhu Z, Hu Y, Chen L, Leung CY, Wu JT, Zhang Z, Zhang X, Peiris JS, Xu J. Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013 . Euro Surveill. 2013;18(50):pii=20657. Available online: http://www.eurosurveillance.org/View...rticleId=20657
Date of submission: 11 November 2013
_________
The novel avian influenza A(H7N9) infection has recently emerged to cause severe respiratory illness in China. The objectives of this study were to define the kinetics of the antibody responses in patients with influenza A(H7N9) disease and to correlate these kinetics with clinical outcome. Serial serum samples were obtained at intervals of three to four days from 18 patients with virologically confirmed A(H7N9) disease in Shanghai. We determined the kinetics of the haemagglutination inhibition (HI) and A(H7H9) pseudotype neutralisation antibody (Nab) responses and correlated these with clinical outcomes. Most patients had robust serological responses by both HI and Nab tests. Taking into account censoring due to time of testing and death, the median time from onset of illness to Nab titre ≥1:40 was 14 days (95% confidence interval (CI): 11?18 days) in the fatal cases and 10.5 days (95% CI: 7?12) in the survivors (p=0.003). The two groups did not differ in initial Nab titres, but the rate of increase in Nab titres was significantly faster for survivors by approximately 10-fold per 15 days (p=0.007). Early and rapid induction of Nab was correlated significantly with better clinical outcome.
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