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J Infect Dis. An animal model of MERS produced by infection of Rhesus Macaques with MERS coronavirus
[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
An animal model of MERS produced by infection of Rhesus Macaques with MERS coronavirus
Yanfeng Yao 1, Linlin Bao 1, Wei Deng 1, Lili Xu 1, Fengdi Li 1, Qi Lv 1, Pin Yu 1, Ting Chen 1, Yanfeng Xu 1, Hua Zhu 1, Jing Yuan 1, Songzhi Gu 1, Qiang Wei 1, Honglin Chen 2, Kwok-Yung Yuen 2 and Chuan Qin 1,*
Author Affiliations: <SUP>1</SUP>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China; <SUP>2</SUP>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and the Research Centre of Infection and Immunology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;
*Corresponding author. Mailing address: Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, No.5, Panjiayuan Nanli, Chaoyang District, Beijing, China. Phone: (086)-10-67761942. Fax: (086)-10-67761943. E-mail: qinchuan@pumc.edu.cn
<CITE><ABBR>J Infect Dis.</ABBR> (2013) doi: 10.1093/infdis/jit590 - </CITE>First published online: November 11, 2013
Abstract
In 2012, a novel coronavirus associated with severe respiratory disease, MERS-CoV (previously known as human coronavirus-EMC or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
Received August 22, 2013. Revision received September 16, 2013. Accepted September 26, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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An animal model of MERS produced by infection of Rhesus Macaques with MERS coronavirus
Yanfeng Yao 1, Linlin Bao 1, Wei Deng 1, Lili Xu 1, Fengdi Li 1, Qi Lv 1, Pin Yu 1, Ting Chen 1, Yanfeng Xu 1, Hua Zhu 1, Jing Yuan 1, Songzhi Gu 1, Qiang Wei 1, Honglin Chen 2, Kwok-Yung Yuen 2 and Chuan Qin 1,*
Author Affiliations: <SUP>1</SUP>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China; <SUP>2</SUP>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and the Research Centre of Infection and Immunology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;
*Corresponding author. Mailing address: Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, No.5, Panjiayuan Nanli, Chaoyang District, Beijing, China. Phone: (086)-10-67761942. Fax: (086)-10-67761943. E-mail: qinchuan@pumc.edu.cn
<CITE><ABBR>J Infect Dis.</ABBR> (2013) doi: 10.1093/infdis/jit590 - </CITE>First published online: November 11, 2013
Abstract
In 2012, a novel coronavirus associated with severe respiratory disease, MERS-CoV (previously known as human coronavirus-EMC or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
Received August 22, 2013. Revision received September 16, 2013. Accepted September 26, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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