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J Virol. Human H7N9 Influenza A Viruses Replicate in Swine Respiratory Tissue Explants.
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Virol. 2013 Sep 11. [Epub ahead of print]
Human H7N9 Influenza A Viruses Replicate in Swine Respiratory Tissue Explants.
Jones JC, Baranovich T, Zaraket H, Guan Y, Shu Y, Webby RJ, Webster RG.
Source: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Abstract
Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replicated efficiently in tracheas and bronchi of the explants, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.
PMID: 24027310 [PubMed - as supplied by publisher]
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J Virol. 2013 Sep 11. [Epub ahead of print]
Human H7N9 Influenza A Viruses Replicate in Swine Respiratory Tissue Explants.
Jones JC, Baranovich T, Zaraket H, Guan Y, Shu Y, Webby RJ, Webster RG.
Source: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Abstract
Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replicated efficiently in tracheas and bronchi of the explants, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.
PMID: 24027310 [PubMed - as supplied by publisher]
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