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J Infect Dis. Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study
<CITE><ABBR>[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]</ABBR></CITE>
<CITE><ABBR></ABBR></CITE>
<CITE><ABBR></ABBR></CITE><CITE><ABBR>J Infect Dis.</ABBR> (2013) doi: 10.1093/infdis/jit430 - </CITE>First published online: August 9, 2013
Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study
Shigui Yang 1,3,*, Yu Chen 1,3,*, Dawei Cui 1, Hangping Yao 1,3, Jianzhou Lou 1, Zhaoxia Huo 1, Guoliang Xie 1, Fei Yu 1, Shufa Zheng 1, Yida Yang 1, Yixin Zhu 1, Xiaoqing Lu 1, Xiaoli Liu 1, Siu-Ying Lau 2,3, Jasper Fuk-Woo Chan 2, Kelvin Kai-Wang To 2, Kwok-Yung Yuen 2,3, Honglin Chen 2,3,# and Lanjuan Li 1,3,#
Author Affiliations: <SUP>1</SUP>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003,China <SUP>2</SUP>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China <SUP>3</SUP>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China
#Correspondence: Lanjuan Li at the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China or at ljli@zju.edu.cn, or Honglin Chen at State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China, or at hlchen@hku.hk
* These authors equally contributed to this work.
Abstract
Serological surveillance conducted in H7N9 outbreak areas of China found no sero-positivity for antibodies specific for avian-origin H7N9 virus among 1129 individuals of the general population, whereas greater than 6% among 396 poultry workers were positive (HI titers ≥80), confirming that infected poultry is the principal source of human infections and subclinical infections are possible. Elevated antibodies to the H7N9 virus were found in 65.8% (25/38) of survival cases but only in 28.6% (2/7) of fatal cases after an interval of 10-14 days, suggesting the presence of antibodies may improve clinical outcome in infected patients.
Received June 7, 2013. Revision received July 2, 2013. Accepted July 12, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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<CITE><ABBR></ABBR></CITE>
<CITE><ABBR></ABBR></CITE><CITE><ABBR>J Infect Dis.</ABBR> (2013) doi: 10.1093/infdis/jit430 - </CITE>First published online: August 9, 2013
Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study
Shigui Yang 1,3,*, Yu Chen 1,3,*, Dawei Cui 1, Hangping Yao 1,3, Jianzhou Lou 1, Zhaoxia Huo 1, Guoliang Xie 1, Fei Yu 1, Shufa Zheng 1, Yida Yang 1, Yixin Zhu 1, Xiaoqing Lu 1, Xiaoli Liu 1, Siu-Ying Lau 2,3, Jasper Fuk-Woo Chan 2, Kelvin Kai-Wang To 2, Kwok-Yung Yuen 2,3, Honglin Chen 2,3,# and Lanjuan Li 1,3,#
Author Affiliations: <SUP>1</SUP>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003,China <SUP>2</SUP>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China <SUP>3</SUP>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China
#Correspondence: Lanjuan Li at the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China or at ljli@zju.edu.cn, or Honglin Chen at State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China, or at hlchen@hku.hk
* These authors equally contributed to this work.
Abstract
Serological surveillance conducted in H7N9 outbreak areas of China found no sero-positivity for antibodies specific for avian-origin H7N9 virus among 1129 individuals of the general population, whereas greater than 6% among 396 poultry workers were positive (HI titers ≥80), confirming that infected poultry is the principal source of human infections and subclinical infections are possible. Elevated antibodies to the H7N9 virus were found in 65.8% (25/38) of survival cases but only in 28.6% (2/7) of fatal cases after an interval of 10-14 days, suggesting the presence of antibodies may improve clinical outcome in infected patients.
Received June 7, 2013. Revision received July 2, 2013. Accepted July 12, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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