[Source: Emerging Microbes and Infections, full page: (LINK). Extract.]
Citation: Emerging Microbes & Infections (2013) 2, e41; doi:10.1038/emi.2013.41 - Published online 10 July 2013
Mild infection of a novel H7N9 avian influenza virus in children in Shanghai
Open
Xuelian Yu<SUP>1,*</SUP>, Xi Zhang<SUP>1,*</SUP>, Yi He<SUP>1,*</SUP>, Huanyu Wu<SUP>1</SUP>, Xia Gao<SUP>2</SUP>, Qichao Pan<SUP>1</SUP>, Jiaren Shen<SUP>1</SUP>, Jianming Zhu<SUP>2</SUP>, Hongyou Chen<SUP>1</SUP>, Yiyi Zhu<SUP>1</SUP>, Fan Wu<SUP>1</SUP>, Jianwei Wang<SUP>3</SUP> and Zhengan Yuan<SUP>1</SUP>
<SUP></SUP>
<SUP>1</SUP>Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201599, China <SUP>2</SUP>Shanghai Jinshan District Center for Disease Control and Prevention, Shanghai , China <SUP>3</SUP>MOH Key Laboratory of System Pathogen Biology and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Bejing 100730, China
Correspondence: ZA Yuan, E-mail: zayuan@scdc.sh.cn; JW Wang, E-mail: wangjw28@163.com
<SUP>*</SUP>These authors contributed equally to this paper.
Received 24 April 2013; Revised 20 May 2013; Accepted 6 June 2013
Dear Editor, Human infection by avian influenza virus (AIV) subtypes H7<SUP>1,2</SUP> and H9N2<SUP>3</SUP> has been reported in various countries over the past few years. Recent research reveals that AIV subtype H7 shares some properties with subtype H5, including causing severe disease in birds<SUP>4</SUP> and outbreaks involving large numbers of infected humans.<SUP>1,5</SUP> Since March 30th, 2013, a reassortment avian-origin influenza A (H7N9) virus characterized by a unique combination of gene segments identified among previous AIV subtype H7N3 (ZJ12), H7N9 (KO14) and H9N2 (BJ16) viruses<SUP>6</SUP> has caused a large number of human infections in China (33 infections, including 14 deaths in Shanghai). The sudden appearance of this disease with high case fatality and severe clinical manifestations has attracted substantial scientific and popular attention and has impacted human health and the economy. Given its wide and rapid spread within China, the newly defined influenza A virus H7N9 may possess pandemic potential. Efficient preparations should be made, but such efforts are complicated by the fact that the clinical traits regarding this new disease remain unclear.
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Citation: Emerging Microbes & Infections (2013) 2, e41; doi:10.1038/emi.2013.41 - Published online 10 July 2013
Mild infection of a novel H7N9 avian influenza virus in children in Shanghai
Open
Xuelian Yu<SUP>1,*</SUP>, Xi Zhang<SUP>1,*</SUP>, Yi He<SUP>1,*</SUP>, Huanyu Wu<SUP>1</SUP>, Xia Gao<SUP>2</SUP>, Qichao Pan<SUP>1</SUP>, Jiaren Shen<SUP>1</SUP>, Jianming Zhu<SUP>2</SUP>, Hongyou Chen<SUP>1</SUP>, Yiyi Zhu<SUP>1</SUP>, Fan Wu<SUP>1</SUP>, Jianwei Wang<SUP>3</SUP> and Zhengan Yuan<SUP>1</SUP>
<SUP></SUP>
<SUP>1</SUP>Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201599, China <SUP>2</SUP>Shanghai Jinshan District Center for Disease Control and Prevention, Shanghai , China <SUP>3</SUP>MOH Key Laboratory of System Pathogen Biology and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Bejing 100730, China
Correspondence: ZA Yuan, E-mail: zayuan@scdc.sh.cn; JW Wang, E-mail: wangjw28@163.com
<SUP>*</SUP>These authors contributed equally to this paper.
Received 24 April 2013; Revised 20 May 2013; Accepted 6 June 2013
Dear Editor, Human infection by avian influenza virus (AIV) subtypes H7<SUP>1,2</SUP> and H9N2<SUP>3</SUP> has been reported in various countries over the past few years. Recent research reveals that AIV subtype H7 shares some properties with subtype H5, including causing severe disease in birds<SUP>4</SUP> and outbreaks involving large numbers of infected humans.<SUP>1,5</SUP> Since March 30th, 2013, a reassortment avian-origin influenza A (H7N9) virus characterized by a unique combination of gene segments identified among previous AIV subtype H7N3 (ZJ12), H7N9 (KO14) and H9N2 (BJ16) viruses<SUP>6</SUP> has caused a large number of human infections in China (33 infections, including 14 deaths in Shanghai). The sudden appearance of this disease with high case fatality and severe clinical manifestations has attracted substantial scientific and popular attention and has impacted human health and the economy. Given its wide and rapid spread within China, the newly defined influenza A virus H7N9 may possess pandemic potential. Efficient preparations should be made, but such efforts are complicated by the fact that the clinical traits regarding this new disease remain unclear.
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