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J Virol. Identification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development.
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
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J Virol. 2013 Jul 3. [Epub ahead of print]
Identification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development.
Du L, Zhao G, Kou Z, Ma C, Sun S, Poon VK, Lu L, Wang L, Debnath AK, Zheng BJ, Zhou Y, Jiang S.
Source: Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Abstract
A novel human coronavirus (MERS-CoV) caused outbreaks of SARS-like illness with high mortality rate, raising concerns of its pandemic potential. Dipeptidyl peptidase-4 (DPP4) was recently identified as its receptor. Here we showed that residues 377-662 in S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP4 protein, and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as MERS-CoV vaccine.
PMID: 23824801 [PubMed - as supplied by publisher]
-Identification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development.
Du L, Zhao G, Kou Z, Ma C, Sun S, Poon VK, Lu L, Wang L, Debnath AK, Zheng BJ, Zhou Y, Jiang S.
Source: Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Abstract
A novel human coronavirus (MERS-CoV) caused outbreaks of SARS-like illness with high mortality rate, raising concerns of its pandemic potential. Dipeptidyl peptidase-4 (DPP4) was recently identified as its receptor. Here we showed that residues 377-662 in S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP4 protein, and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as MERS-CoV vaccine.
PMID: 23824801 [PubMed - as supplied by publisher]
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