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J Virol. Bilateral Entry and Release of Middle East Respiratory Syndrome-Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells.
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
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J Virol. 2013 Jul 3. [Epub ahead of print]
Bilateral Entry and Release of Middle East Respiratory Syndrome-Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells.
Tao X, Hill TE, Morimoto C, Peters CJ, Ksiazek TG, Tseng CT.
Source: Departments of Microbiology and Immunology.
Abstract
The newly emerged MERS-CoV infects human bronchial epithelial Calu-3 cells. Unlike SARS-CoV which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 hrs irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that differs markedly from SARS-CoV.
PMID: 23824802 [PubMed - as supplied by publisher]
-Bilateral Entry and Release of Middle East Respiratory Syndrome-Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells.
Tao X, Hill TE, Morimoto C, Peters CJ, Ksiazek TG, Tseng CT.
Source: Departments of Microbiology and Immunology.
Abstract
The newly emerged MERS-CoV infects human bronchial epithelial Calu-3 cells. Unlike SARS-CoV which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 hrs irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that differs markedly from SARS-CoV.
PMID: 23824802 [PubMed - as supplied by publisher]
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