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J Virol. Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin.
[Source: US National Library of Medicine, full text: (LINK). Abstract, edited.]
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J Virol. 2013 May 22. [Epub ahead of print]
Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin.
Goff PH, Krammer F, Hai R, Seibert CW, Margine I, Garc?a-Sastre A, Palese P.
Source: Department of Microbiology.
Abstract
Severe human disease caused by the emerging H7N9 influenza virus in China warrants rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice are cross-reactive to a broad range of H7 subtype viruses and inhibit hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggests that cross-protective antibodies recognize conserved antigenic sites.
PMID: 23698299 [PubMed - as supplied by publisher]
-Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin.
Goff PH, Krammer F, Hai R, Seibert CW, Margine I, Garc?a-Sastre A, Palese P.
Source: Department of Microbiology.
Abstract
Severe human disease caused by the emerging H7N9 influenza virus in China warrants rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice are cross-reactive to a broad range of H7 subtype viruses and inhibit hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggests that cross-protective antibodies recognize conserved antigenic sites.
PMID: 23698299 [PubMed - as supplied by publisher]
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