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Risk Anal. 2011 Feb 1. doi: 10.1111/j.1539-6924.2010.01575.x. [Epub ahead of print]
Quantitative Links Between Arsenic Exposure and Influenza A (H1N1) Infection-Associated Lung Function Exacerbations Risk.
Liao CM, Chio CP, Cheng YH, Hsieh NH, Chen WY, Chen SC.
Abstract
The objective of this study was to link arsenic exposure and influenza A (H1N1) infection-induced respiratory effects to assess the impact of arsenic-contaminated drinking water on exacerbation risk of A (H1N1)-associated lung function. The homogeneous Poisson process was used to approximate the related processes between arsenic exposure and influenza-associated lung function exacerbation risk. We found that (i) estimated arsenic-induced forced expiratory volume in 1 second (FEV(1) ) reducing rates ranged from 0.116 to 0.179 mL/μg for age 15-85 years, (ii) estimated arsenic-induced A (H1N1) viral load increasing rate was 0.5 mL/μg, (iii) estimated A (H1N1) virus-induced FEV(1) reducing rate was 0.10 mL/logTCID50, and (iv) the relationship between arsenic exposure and A (H1N1)-associated respiratory symptoms scores (RSS) can be described by a Hill model. Here we showed that maximum RSS at day 2 postinfection for Taiwan, West Bengal (India), and the United States were estimated to be in the severe range of 0.83, 0.89, and 0.81, respectively, indicating that chronic arsenic exposure and A (H1N1) infection together are most likely to pose potential exacerbations risk of lung function, although a 50% probability of lung function exacerbations risk induced by arsenic and influenza infection was within the mild and moderate ranges of RSS at day 1 and 2 postinfection. We concluded that avoidance of drinking arsenic-containing water could significantly reduce influenza respiratory illness and that need will become increasingly urgent as the novel H1N1 pandemic influenza virus infects people worldwide.
? 2011 Society for Risk Analysis.
PMID: 21284682 [PubMed - as supplied by publisher]
Quantitative Links Between Arsenic Exposure and Influenza A (H1N1) Infection-Associated Lung Function Exacerbations Risk.
Liao CM, Chio CP, Cheng YH, Hsieh NH, Chen WY, Chen SC.
Abstract
The objective of this study was to link arsenic exposure and influenza A (H1N1) infection-induced respiratory effects to assess the impact of arsenic-contaminated drinking water on exacerbation risk of A (H1N1)-associated lung function. The homogeneous Poisson process was used to approximate the related processes between arsenic exposure and influenza-associated lung function exacerbation risk. We found that (i) estimated arsenic-induced forced expiratory volume in 1 second (FEV(1) ) reducing rates ranged from 0.116 to 0.179 mL/μg for age 15-85 years, (ii) estimated arsenic-induced A (H1N1) viral load increasing rate was 0.5 mL/μg, (iii) estimated A (H1N1) virus-induced FEV(1) reducing rate was 0.10 mL/logTCID50, and (iv) the relationship between arsenic exposure and A (H1N1)-associated respiratory symptoms scores (RSS) can be described by a Hill model. Here we showed that maximum RSS at day 2 postinfection for Taiwan, West Bengal (India), and the United States were estimated to be in the severe range of 0.83, 0.89, and 0.81, respectively, indicating that chronic arsenic exposure and A (H1N1) infection together are most likely to pose potential exacerbations risk of lung function, although a 50% probability of lung function exacerbations risk induced by arsenic and influenza infection was within the mild and moderate ranges of RSS at day 1 and 2 postinfection. We concluded that avoidance of drinking arsenic-containing water could significantly reduce influenza respiratory illness and that need will become increasingly urgent as the novel H1N1 pandemic influenza virus infects people worldwide.
? 2011 Society for Risk Analysis.
PMID: 21284682 [PubMed - as supplied by publisher]
