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Re: UK Genetic Evaluation thread
> According to the narrative, these sequences have apparently been
> processed through a program of your authorship?
mixin uses my mutatm.exe to extract the mutations
several other programs are at http://magictour.free.fr/seq
or on request
> Clear indications of severity markers and Vaccine Escape domains are available as are
> indications of drug resistance.
these are not specific to substrains but occur independently on several backgrounds
> Some outdated material has been produced and analysed to little effect due to scarcity
> and unreliable parameters.
sequencing gets plentiful and cheap ... someone should do a better analysis and publish it
> Such small point factors are unreliable for many reasons, but, most importantly, due to
> various synergies among combinations of polymorphisms, some that produce little net
> effect and others that produce multiplicative effect. The record is observable on these matters.
we do what we can. I have not yet seen that analysis.
Once the data is available we can also easily test it for combinations
> Calculations based on selected combinations of polymorphisms chosen by frequency /
> absence on a background among other factors may provide comparisons that feedback
> to the choice of SNPs to include on that calculation. Due to sparsity of data and clinical
> meta-data, the calculations must be iterated and interpreted with a high level of
> earnestness and objectivity.
should be possible. We should also include info on the antigenic situation of
the population before infection
> The data have been produced by HPA and provided in spreadsheet format.
> Transparency and timely reporting is not occurring, nor do we expect valid
> data in the near term.
average age this season = ?
average age last season = ?
> Though novelty and divergency is now the norm in the UK reservoir, one of the strains
> that was previously found in a robust form during the late Australia winter season is
> easily trackable.
which one ? (use mixin letters above)
> Emergence began in late 2009 in the United States of the most frequent background and
> continued via domaining during the early part of 2010 and the summer in the
> Northern Hemisphere, translating well into the winter in the Southern Hemisphere.
did it "emerge" and spread from USA in late 2009 ? Where was it before ?
> According to the narrative, these sequences have apparently been
> processed through a program of your authorship?
mixin uses my mutatm.exe to extract the mutations
several other programs are at http://magictour.free.fr/seq
or on request
> Clear indications of severity markers and Vaccine Escape domains are available as are
> indications of drug resistance.
these are not specific to substrains but occur independently on several backgrounds
> Some outdated material has been produced and analysed to little effect due to scarcity
> and unreliable parameters.
sequencing gets plentiful and cheap ... someone should do a better analysis and publish it
> Such small point factors are unreliable for many reasons, but, most importantly, due to
> various synergies among combinations of polymorphisms, some that produce little net
> effect and others that produce multiplicative effect. The record is observable on these matters.
we do what we can. I have not yet seen that analysis.
Once the data is available we can also easily test it for combinations
> Calculations based on selected combinations of polymorphisms chosen by frequency /
> absence on a background among other factors may provide comparisons that feedback
> to the choice of SNPs to include on that calculation. Due to sparsity of data and clinical
> meta-data, the calculations must be iterated and interpreted with a high level of
> earnestness and objectivity.
should be possible. We should also include info on the antigenic situation of
the population before infection
> The data have been produced by HPA and provided in spreadsheet format.
> Transparency and timely reporting is not occurring, nor do we expect valid
> data in the near term.
average age this season = ?
average age last season = ?
> Though novelty and divergency is now the norm in the UK reservoir, one of the strains
> that was previously found in a robust form during the late Australia winter season is
> easily trackable.
which one ? (use mixin letters above)
> Emergence began in late 2009 in the United States of the most frequent background and
> continued via domaining during the early part of 2010 and the summer in the
> Northern Hemisphere, translating well into the winter in the Southern Hemisphere.
did it "emerge" and spread from USA in late 2009 ? Where was it before ?
) I covered it in post 
. Where I put California/7 in my last post it should have been B/Brisbane/60/2008-like virus which is the 2010/11 Northern Hemisphere Type B component of the Trivalent Vaccine.
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