MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

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<!-- content area --> <!-- body area --> Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection --- California, April--May, 2009

Since April 15 and 17, 2009, when the first two cases of novel influenza A (H1N1) infection were identified from two southern California counties, novel influenza A (H1N1) cases have been documented throughout the world, with most cases occurring in the United States and Mexico (1--3). In the United States, early reports of illnesses associated with novel influenza A (H1N1) infection indicated the disease might be similar in severity to seasonal influenza, with the majority of patients not requiring hospitalization and only rare deaths reported, generally in persons with underlying medical conditions (2,3). As of May 17, 2009, 553 novel influenza A (H1N1) cases, including 333 confirmed and 220 probable cases, had been reported in 32 of 61 local health jurisdictions in California. Of the 553 patients, 30 have been hospitalized. No fatal cases associated with novel influenza A (H1N1) infection had been reported in California. This report summarizes the 30 hospitalized cases as of May 17, including a detailed description of four cases that illustrate the spectrum of illness severity and underlying risk factors. This preliminary overview indicates that, although the majority of hospitalized persons infected with novel influenza A (H1N1) recovered without complications, certain patients had severe and prolonged disease. All hospitalized patients with novel influenza A (H1N1) infection should be monitored carefully and treated with antiviral therapy, including patients who seek care >48 hours after illness onset (4,5).
Summary of Hospitalized Cases
Beginning on April 20, 2009, the California Department of Public Health (CDPH) and local health departments in Imperial and San Diego counties worked with hospital infection-control practitioners to initiate enhanced surveillance for hospitalized cases of laboratory-confirmed or probable novel influenza A (H1N1) infection at all 25 hospitals in the two counties. Three days later, on April 23, 2009, CDPH extended this surveillance statewide. Cases are reported as either probable (defined as detection of influenza A by real-time reverse transcription--polymerase chain reaction [rRT-PCR] that is unsubtypable for human influenza virus subtypes H1 or H3) or confirmed (defined as positive by CDC protocol for rRT-PCR for novel influenza A H1N1).* Approximately 96% of unsubtypable California specimens subsequently have been confirmed as novel influenza A (H1N1) at CDC or at the CDPH Viral and Rickettsial Disease Laboratory (VRDL).?
For this report, a hospitalized case was defined as a confirmed or probable case of novel influenza A (H1N1) infection in a patient who was hospitalized for ≥24 hours. Of the 30 hospitalized patients, 26 were confirmed and four were probable (confirmatory testing is in progress); symptom onset ranged from April 3 to May 9. The cases were reported from 11 counties, most of which are located in southern or central California. The largest number of patients, (15 [50%]) resided in San Diego and Imperial counties. Of the 26 patients for whom information on ethnicity was available, 17 (65%) were Hispanic. Ages of the 30 patients ranged from 27 days to 89 years, with a median age of 27.5 years; 21 (70%) were female. Four (13%) patients had traveled to Mexico in the 7 days before onset of illness. None of the 30 patients reported exposure to swine or a known confirmed case of novel influenza A (H1N1) infection.
The most common admission diagnoses were pneumonia and dehydration. Nineteen patients (64%) had underlying medical conditions; the most common were chronic lung disease (e.g., asthma and chronic obstructive pulmonary disease), conditions associated with immunosuppresion, chronic cardiac disease (e.g., congenital heart disease and coronary artery disease), diabetes, and obesity. The most common symptoms were fever, cough, vomiting, and shortness of breath; diarrhea was uncommon. Of the 25 patients who had chest radiographs, 15 (60%) had abnormalities suggestive of pneumonia, including 10 with multilobar infiltrates and five with unilobar infiltrates. Six patients were admitted to the intensive care unit (ICU), and four required mechanical ventilation. Five patients were pregnant. Two of these developed complications, including spontaneous abortion and premature rupture of the membranes; the fetuses were at 13 and 35 weeks gestation, respectively.
Of the 24 patients tested for influenza A in the hospital, the rapid antigen test was positive in 16 and negative in five; three patients tested positive by other methods (direct immunofluorescent antibody [two patients] and culture [one patient]). None of the 30 patients had microbiologic evidence of secondary bacterial infection by blood, urine, or sputum cultures (or endotracheal aspirate or bronchoalveolar lavage cultures in the case of intubated patients). Fifteen (50%) received antiviral treatment with oseltamivir; for five patients, treatment was initiated within 48 hours of onset of symptoms. Among the 15 not treated with antivirals, six sought care >48 hours after illness onset. Of the 22 patients with available history, six (27%) had received seasonal influenza vaccination. As of May 17, 23 patients had been discharged to home, with a median length of hospital stay of 4 days (range: 1--10 days). Seven patients remained in the hospital, with median lengths of stay of 15 days (range: 4--167 days) (Tables 1 and 2).
Case Reports
Patient 3. An infant girl aged 5 months was born prematurely at 27 weeks in early December 2008 with intrauterine growth retardation and congenital heart disease with patent ductus arteriosus and ventricular septal defect. The infant had a complicated hospital course in the neonatal ICU after birth, including development of bronchopulmonary dysplasia and respiratory distress syndrome requiring prolonged mechanical ventilation and multiple courses of steroids, several episodes of clinical sepsis and pneumonia, and chronic anemia and thrombocytopenia. By the fifth month, the infant had been weaned from the ventilator and was doing well on high-flow nasal cannula oxygen. However, on hospital day number 150, she developed a new nonproductive cough and fever, with a new infiltrate of the right lung on chest radiograph that progressed to complete opacification of both lung fields. Multiple blood, urine, and sputum cultures were unrevealing; rapid antigen test was positive for influenza A, with subsequent confirmation at the CDPH VRDL for novel influenza A (H1). The source of the infant's infection is still under investigation. The infant was reintubated and started on broad spectrum antibiotics and oseltamivir at a dose of 2 mg/kg every 12 hours, 3 days after fever. As of May 14, the patient remained hospitalized in critical condition.
Patient 16. A previously healthy woman aged 29 years, who was 28 weeks pregnant, sought care at an emergency department on April 26 with complaints of subjective fever, productive cough, and increasing shortness of breath during the preceding 10 days. Upon initial evaluation, the patient's vital signs were notable for low grade fever (99.6?F [37.6?C]), a respiratory rate of 38 breaths per minute, blood pressure of 112/57 mmHg, heart rate of 104 beats per minute, and oxygen saturation of 87% on room air. A chest radiograph revealed bilateral perihilar interstitial infiltrates with mediastinal lymphadenopathy. Her complete blood count and chemistries were normal except for an elevated white blood cell count of 11.4 cells/mm3 with a differential of 42% segmented neutrophils, 45% bands, and 9% lymphocytes. The patient was admitted to the ICU and started on broad spectrum antibiotics (azithromycin and ceftriaxone). Serial fetal ultrasounds were normal. Multiple blood, urine, and sputum cultures were unrevealing; rapid antigen test was positive for influenza A, with subsequent confirmation of novel influenza A (H1N1) at the CDPH VRDL. She was not treated with antiviral medications. She gradually improved and was discharged on amoxicillin after 9 days.
Patient 18. A man aged 32 years with a history of obstructive sleep apnea sought care at an emergency department on May 5 with a 3-day history of fever, chills, and productive cough. The patient reported he had been taking amoxicillin for a diagnosis of sinusitis, following complaints of vertigo and dizziness, for the past 2 weeks. His vital signs showed a temperature of 99.1?F (37.3?C), blood pressure of 89/58 mmHg, and heart rate of 84 beats per minute. Physical exam of the chest showed good air movement bilaterally, although chest radiograph revealed bilateral infiltrates. His complete blood count and chemistries were normal except for an elevated white blood cell count of 13.8 cells/mm3 with a differential of 94% segmented neutrophils and 4% lymphocytes. An arterial blood gas showed respiratory acidosis and hypoxemia with pO2 of 80 mm Hg on room air. The patient was admitted to the ICU on empiric broad spectrum antibiotics and required intubation on the second hospital day for worsening hypoxemia. Initial microbiologic workup and influenza rapid antigen tests were negative; the patient was started on oseltamivir on hospital day 2. A repeat rapid antigen test and bronchoalveolar lavage viral culture were positive for influenza A, with subsequent confirmation of novel influenza A (H1N1). The patient improved, was extubated on hospital day 5, and was discharged on hospital day 10.
Patient 29. A woman aged 87 years with multiple medical problems, including recently diagnosed breast cancer with possible abdominal metastasis, hypertension, diabetes mellitus, coronary artery disease, cerebrovascular disease, chronic renal insufficiency, and obesity, was brought for care at an emergency department on April 21 after being found unconscious by her daughter. The patient had reported onset of fever, cough, and weakness 2 days before admission and also new onset of orthopnea and bilateral leg swelling. She was wheelchair bound and had no recent history of travel or known contact with ill persons.. In the emergency room the patient was afebrile, with a blood pressure of 57/39 mmHg, pulse 57, respiratory rate of 14 breaths per minute, and oxygen saturation of 87% on room air. Electrocardiogram was suggestive of non Q-wave myocardial infarction. Chest radiograph showed bilateral pneumonia and congestive heart failure with marked cardiomegaly. Her laboratory abnormalities included an elevated white blood cell count of 13.4 cells/mm3, mild anemia with a hematocrit of 34%, a mildly elevated creatinine at 1.8 mg/dL, alanine aminotransferase of 36 units/L and aspartate aminotransferase of 160 units/L, and markedly elevated troponin and creatinine kinase levels of 29.43 ng/mL and 653 IU/L, respectively. The patient went into respiratory arrest and was subsequently intubated and started on low dose dopamine, and admitted to the ICU with a diagnosis of myocardial infarction, congestive heart failure, pneumonia and presumed sepsis. A chest computed tomography (CT) scan showed complete atelectasis of the right middle lobe, bilateral ground glass opacities of the upper lobes, and bilateral pleural effusions. A subsequent bronchoscopy identified a large cauliflower-shaped mass in the right lower lobe airway. Multiple blood, urine, and sputum cultures were unrevealing; rapid antigen test was positive for influenza A, with subsequent confirmation of novel influenza A (H1N1) at the CDPH VRDL. The patient remains hospitalized in critical condition under intensive care.
Reported by: J Louie, MD, K Winter, MPH, K Harriman, PhD, D Vugia, MD, C Glaser, MD, B Matyas, MD, D Schnurr, PhD, H Guevara, MS, CY Pan, E Saguar, R Berumen, E Hunley, S Messenger, PhD, C Preas, D Hatch, MD, G Chavez, MD, California Dept of Public Health. P Kriner, MPH, K Lopez, MD, Imperial County Public Health Dept; D Sunega, D Rexin, San Diego County Health and Human Svcs; Los Angeles County Swine Flu Surveillance Team, Los Angeles County Dept of Public Health; S Roach, J Kempf, Tulare County Health and Human Svcs Agency; R Gonzalez, L Morgan, MPH, San Bernardino County Dept of Public Health, California. N Barnes, MS, L Berman, MS, S Emery, MPH, B Shu, MD, KH Wu, PhD, J Villanueva, PhD, S Lindstrom, PhD, Influenza Div; D Sugarman, MD, M Patel, MD, J Jaeger, MD, E Meites, MD, N Dharan, MD, EIS officers, CDC.
Editorial Note:

Initial surveillance for hospitalized cases of novel influenza A (H1N1) infection in California indicates that the majority of patients were discharged after short hospital stays. Previously healthy patients without underlying chronic medical conditions recovered with an uncomplicated hospital course and a median length of stay of 2.5 days (range: 1--7 days). Although one third of hospitalized patients had abnormal chest radiographs with multilobar infiltrates, only 9% were treated with oseltamivir; nonetheless, most had favorable outcomes. Of five pregnant women, two developed serious sequelae; however, the role that preceding infection with novel influenza A (H1N1) played in these outcomes is unclear.
Certain hospitalized patients in California experienced severe disease and prolonged hospital courses. Of note, three of the six California patients admitted to an ICU continue to require prolonged intensive care. Extremes in age and multiple and debilitating underlying medical conditions might be contributing to the severity of illness in these patients. Although chronic underlying medical conditions and pregnancy classically are associated with a greater risk for complications for seasonal influenza (6), one patient (patient 18) who was relatively healthy with only mild chronic pulmonary disease required intensive care and mechanical ventilation. More data are needed regarding which populations are at greatest risk for hospitalization and severe sequelae after infection with novel influenza A (H1N1).
As of May 15, 2009, 9% of approximately 11,600 clinical specimens submitted for testing to California public health laboratories since April 27, 2009, were positive by rRT-PCR for influenza A; of those, 23% and 28% were subtyped as seasonal influenza A/H1 and A/H3, respectively. These results indicate that seasonal influenza viruses continue to circulate throughout California and might be a cause of influenza-like illness and positive results from rapid antigen tests. Although rapid antigen test results were positive in 67% of tested cases in this series, anecdotal reports from other cases confirmed at CDPH VRDL, tested mostly in the outpatient setting, suggest that false positive and negative results are common. Accordingly, CDPH has emphasized the importance of testing influenza viruses in the state with rRT-PCR. CDPH also has advised clinicians in California to collect respiratory specimens for rRT-PCR testing, subtyping, and further characterization at public health laboratories from patients who are hospitalized or who die with febrile respiratory illness.
Additional information regarding California testing guidelines is available at http://ww2.cdph.ca.gov/programs/vrdl/pages/diagnostictestingforswineinfluenzaA(H1).aspx. Additional information regarding novel influenza A (H1N1) treatment guidance and other CDC recommendations is available at http://www.cdc.gov/h1n1flu/guidance.
References

1. CDC. Swine influenza A (H1N1) infection in two children---southern California, March--April 2009. MMWR 2009;58:400--2.
2. Dawood FS, Jain S, Finelli L, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;361[online]. Available at http://content.nejm.org/cgi/content/full/nejmoa0903810.
3. CDC. Outbreak of swine-origin influenza A (H1N1) virus infection---Mexico, March--April 2009. MMWR 2009;58:467--70.
4. CDC. Novel influenza A (H1N1) virus infections in three pregnant women---United States, April--May 2009. MMWR 2009;58:497--500.
5. McGeer A, Green KA, Plevneshi A, et al; Toronto Invasive Bacterial Diseases Network. Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada. Clin Infect Dis 2007;45:1568--75.
6. CDC. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008. MMWR 2008;57(No. RR-7).

* Additional information available at http://www.who.int/csr/resources/pub.../en/index.html.
? Additional information available at http://ww2.cdph.ca.gov/programs/vrdl/pages/enhancedsurveillanceforinfluenzaa(h1).aspx.

<table class="data-table"> <tbody> <tr> <th class="header-row" scope="col" colspan="3"> TABLE 1. Case characteristics for 30 hospitalized patients with novel influenza A (H1N1) --- California, April 15, 2009--May 17, 2009
</th> </tr> <tr> <th class="column-head" scope="col"> Case characteristic
</th> <th class="column-head" scope="col"> No.
</th> <th class="column-head" scope="col"> (%)
</th> </tr> <tr> <td class="data-row" scope="row"> Age group (yrs)
</td> <td class="data-row">
</td> <td class="data-row">
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> <5
</td> <td class="data-row" align="right"> 6
</td> <td class="data-row" align="right"> (20)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> 5-19
</td> <td class="data-row" align="right"> 7
</td> <td class="data-row" align="right"> (23)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> 20-39
</td> <td class="data-row" align="right"> 8
</td> <td class="data-row" align="right"> (27)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> 40-59
</td> <td class="data-row" align="right"> 4
</td> <td class="data-row" align="right"> (13)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> >60
</td> <td class="data-row" align="right"> 5
</td> <td class="data-row" align="right"> (17)
</td> </tr> <tr> <td class="space-row" scope="row"> Chronic comorbid illness*
</td> <td class="space-row" align="right">
</td> <td class="space-row" align="right">
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Chronic lung disease?
</td> <td class="data-row" align="right"> 11
</td> <td class="data-row" align="right"> (37)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Other immunosuppression?
</td> <td class="data-row" align="right"> 6
</td> <td class="data-row" align="right"> (20)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Chronic cardiac disease?
</td> <td class="data-row" align="right"> 5
</td> <td class="data-row" align="right"> (17)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Diabetes mellitus
</td> <td class="data-row" align="right"> 4
</td> <td class="data-row" align="right"> (13)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Obesity
</td> <td class="data-row" align="right"> 4
</td> <td class="data-row" align="right"> (13)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Seizure disorder
</td> <td class="data-row" align="right"> 3
</td> <td class="data-row" align="right"> (10)
</td> </tr> <tr> <td class="space-row" scope="row"> Pregnancy
</td> <td class="space-row" align="right"> 5
</td> <td class="space-row" align="right"> (17)
</td> </tr> <tr> <td class="space-row" scope="row"> Symptoms and signs
</td> <td class="space-row" align="right">
</td> <td class="space-row" align="right">
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Fever
</td> <td class="data-row" align="right"> 29
</td> <td class="data-row" align="right"> (97)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Cough
</td> <td class="data-row" align="right"> 23
</td> <td class="data-row" align="right"> (77)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Vomiting
</td> <td class="data-row" align="right"> 14
</td> <td class="data-row" align="right"> (46)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Shortness of breath
</td> <td class="data-row" align="right"> 13
</td> <td class="data-row" align="right"> (43)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Chills
</td> <td class="data-row" align="right"> 11
</td> <td class="data-row" align="right"> (37)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Sore throat
</td> <td class="data-row" align="right"> 10
</td> <td class="data-row" align="right"> (33)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Body aches
</td> <td class="data-row" align="right"> 10
</td> <td class="data-row" align="right"> (33)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Rhinorrhea
</td> <td class="data-row" align="right"> 9
</td> <td class="data-row" align="right"> (30)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Headache
</td> <td class="data-row" align="right"> 5
</td> <td class="data-row" align="right"> (17)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Conjunctivitis
</td> <td class="data-row" align="right"> 3
</td> <td class="data-row" align="right"> (10)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Diarrhea
</td> <td class="data-row" align="right"> 3
</td> <td class="data-row" align="right"> (10)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Altered mental status
</td> <td class="data-row" align="right"> 2
</td> <td class="data-row" align="right"> (7)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Generalized weakness
</td> <td class="data-row" align="right"> 2
</td> <td class="data-row" align="right"> (7)
</td> </tr> <tr> <td class="space-row" scope="row"> Clinical findings and course
</td> <td class="space-row" align="right">
</td> <td class="space-row" align="right">
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Infiltrates on chest radiograph**
</td> <td class="data-row" align="right"> 15
</td> <td class="data-row" align="right"> (60)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Intensive-care unit admission
</td> <td class="data-row" align="right"> 6
</td> <td class="data-row" align="right"> (20)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Mechanical ventilation
</td> <td class="data-row" align="right"> 4
</td> <td class="data-row" align="right"> (13)
</td> </tr> <tr> <td class="data-inset-cell" scope="row"> Antiviral treatment
</td> <td class="data-row" align="right"> 15
</td> <td class="data-row" align="right"> (50)
</td> </tr> <tr> <td class="footnote-row" colspan="3" scope="row"> * Conditions listed are not mutually exclusive; certain patients had multiple underlying chronic diseases.
? Includes asthma, chronic obstructive pulmonary disorder, bronchopulmonary dysplasia/respiratory distress syndrome, bronchiolitis obliterans organizing pneumonia, Sjogren syndrome, and obstructive sleep apnea.
? Includes congenital heart disease, atrial fibrillation, status-post aortic valve replacement, and coronary artery disease.
? Includes immunosuppressive drugs, cancer, and congenital immunodeficiency.
** Out of 25 cases with chest radiographs.
</td> </tr> </tbody> </table>


<table class="data-table"> <tbody> <tr> <th class="header-row" scope="col" colspan="11"> TABLE 2. Detailed clinical characteristics for 30 hospitalized patients with novel influenza A (H1N1) --- California, April 15, 2009--May 17, 2009 (Continued)
</th> </tr> <tr> <th class="column-head" scope="col"> Patient no.
</th> <th class="column-head" scope="col"> Age
</th> <th class="column-head" scope="col"> Sex
</th> <th class="column-head" scope="col"> Underlying conditions*
</th> <th class="column-head" scope="col"> Admission diagnosis
</th> <th class="column-head" scope="col"> Abnormal complete blood count values
</th> <th class="column-head" scope="col"> Chest radiographic findings
</th> <th class="column-head" scope="col"> Intensive-care unit admission
</th> <th class="column-head" scope="col"> Mechanical ventilation
</th> <th class="column-head" scope="col"> Antiviral treatment
</th> <th class="column-head" scope="col"> Length of stay
</th> </tr> <tr> <td class="text-row" scope="row"> 1
</td> <td class="text-row"> 27 days
</td> <td class="text-row"> F
</td> <td class="text-row"> None
</td> <td class="text-row"> Rule out sepsis
</td> <td class="text-row"> None
</td> <td class="text-row"> Normal
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 3 days
</td> </tr> <tr> <td class="text-row" scope="row"> 2
</td> <td class="text-row"> 6 wks
</td> <td class="text-row"> M
</td> <td class="text-row"> None
</td> <td class="text-row"> Pneumonia
</td> <td class="text-row"> Anemia?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 6 days
</td> </tr> <tr> <td class="text-row" scope="row"> 3
</td> <td class="text-row"> 5 mos
</td> <td class="text-row"> F
</td> <td class="text-row"> Prematurity, intrauterine growth retardation, bronchopulmonary dysplasia, congenital heart disease, chronic corticosteroid administration
</td> <td class="text-row"> Respiratory Distress Syndrome, prematurity
</td> <td class="text-row"> Leukocytosis,? anemia?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> Yes
</td> <td class="text-row"> Yes
</td> <td class="text-row"> None
</td> <td class="text-row"> Still hospitalized: day 167
</td> </tr> <tr> <td class="text-row" scope="row"> 4
</td> <td class="text-row"> 17 mos
</td> <td class="text-row"> M
</td> <td class="text-row"> None
</td> <td class="text-row"> Pneumonia respiratory failure
</td> <td class="text-row"> Leukocytosis,? lymphopenia?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 2 days
</td> </tr> <tr> <td class="text-row" scope="row"> 5
</td> <td class="text-row"> 3 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> None
</td> <td class="text-row"> Dehydration
</td> <td class="text-row"> None
</td> <td class="text-row"> Not done
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 1 day
</td> </tr> <tr> <td class="text-row" scope="row"> 6
</td> <td class="text-row"> 3 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> T-cell immunodeficiency
</td> <td class="text-row"> Pneumonia
</td> <td class="text-row"> Leukocytosis,? anemia?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> Yes
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 5 days
</td> </tr> <tr> <td class="text-row" scope="row"> 7
</td> <td class="text-row"> 7 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Asthma, obesity
</td> <td class="text-row"> Asthma exacerbation
</td> <td class="text-row"> Leukopenia**
</td> <td class="text-row"> Unilobar infiltrate
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 4 days
</td> </tr> <tr> <td class="text-row" scope="row"> 8
</td> <td class="text-row"> 9 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> Asthma
</td> <td class="text-row"> Dehydration
</td> <td class="text-row"> Leukopenia** Lymphopenia?
</td> <td class="text-row"> Hyperinflation, perivascular cuffing
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 5 days
</td> </tr> <tr> <td class="text-row" scope="row"> 9
</td> <td class="text-row"> 15 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> Seizure disorder
</td> <td class="text-row"> Dehydration
</td> <td class="text-row"> Lymphopenia?
</td> <td class="text-row"> Normal
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 1 day
</td> </tr> <tr> <td class="text-row" scope="row"> 10
</td> <td class="text-row"> 15 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> Cerebral palsy, asthma, seizure disorder
</td> <td class="text-row"> Fever, seizure
</td> <td class="text-row"> Thrombocytopenia??
</td> <td class="text-row"> Multilobar infiltrates
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> Still hospitalized: day 11
</td> </tr> <tr> <td class="text-row" scope="row"> 11
</td> <td class="text-row"> 17 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Pregnancy
</td> <td class="text-row"> Not available
</td> <td class="text-row"> Not available
</td> <td class="text-row"> Not available
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 5 days
</td> </tr> <tr> <td class="text-row" scope="row"> 12
</td> <td class="text-row"> 19 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> None
</td> <td class="text-row"> Acute pharyngitis
</td> <td class="text-row"> Lymphopenia?
</td> <td class="text-row"> Normal
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 1 day
</td> </tr> <tr> <td class="text-row" scope="row"> 13
</td> <td class="text-row"> 19 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Pregnancy
</td> <td class="text-row"> Rule out sepsis
</td> <td class="text-row"> Lymphopenia?
</td> <td class="text-row"> Not done
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 2 days
</td> </tr> <tr> <td class="text-row" scope="row"> 14
</td> <td class="text-row"> 21 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> None
</td> <td class="text-row"> Dehydration
</td> <td class="text-row"> None
</td> <td class="text-row"> Normal
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 2 days
</td> </tr> <tr> <td class="text-row" scope="row"> 15
</td> <td class="text-row"> 26 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> None
</td> <td class="text-row"> Pneumonia, respiratory failure
</td> <td class="text-row"> None
</td> <td class="text-row"> Unilobar infiltrate
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 2 days
</td> </tr> <tr> <td class="text-row" scope="row"> 16
</td> <td class="text-row"> 29 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Pregnancy
</td> <td class="text-row"> Pneumonia
</td> <td class="text-row"> Leukocytosis?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> Yes
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 9 days
</td> </tr> <tr> <td class="text-row" scope="row"> 17
</td> <td class="text-row"> 30 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Diabetes melitus, obesity
</td> <td class="text-row"> Viral syndrome, vomiting
</td> <td class="text-row"> None
</td> <td class="text-row"> None
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 1 day
</td> </tr> <tr> <td class="text-row" scope="row"> 18
</td> <td class="text-row"> 32 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> Obstructive sleep apnea
</td> <td class="text-row"> Respiratory failure
</td> <td class="text-row"> Leukocytosis,? lymphopenia?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> Yes
</td> <td class="text-row"> Yes
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 8 days
</td> </tr> </tbody> </table>

<table class="data-table"> <tbody><tr> <th class="header-row" scope="col" colspan="11"> TABLE 2. (Continued) Detailed clinical characteristics for 30 hospitalized patients with novel influenza A (H1N1) --- California, April 15, 2009--May 17, 2009
</th> </tr> <tr> <th class="column-head" scope="col"> Patient no.
</th> <th class="column-head" scope="col"> Age
</th> <th class="column-head" scope="col"> Sex
</th> <th class="column-head" scope="col"> Underlying conditions*
</th> <th class="column-head" scope="col"> Admission diagnosis
</th> <th class="column-head" scope="col"> Abnormal complete blood count values
</th> <th class="column-head" scope="col"> Chest radiographic findings
</th> <th class="column-head" scope="col"> Intensive-care unit admission
</th> <th class="column-head" scope="col"> Mechanical ventilation
</th> <th class="column-head" scope="col"> Antiviral treatment
</th> <th class="column-head" scope="col"> Length of stay
</th> </tr> <tr> <td class="text-row" scope="row"> 19
</td> <td class="text-row"> 34 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Asthma, pregnancy
</td> <td class="text-row"> Dehydration
</td> <td class="text-row"> Leukopenia,** thrombocytopenia??
</td> <td class="text-row"> None
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 7 days
</td> </tr> <tr> <td class="text-row" scope="row"> 20
</td> <td class="text-row"> 35 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> None
</td> <td class="text-row"> Pneumonia
</td> <td class="text-row"> Leukocytosis,? anemia?
</td> <td class="text-row"> Not done
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 7 days
</td> </tr> <tr> <td class="text-row" scope="row"> 21
</td> <td class="text-row"> 35 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Down syndrome, congenital heart defect, congenital T-cell deficiency
</td> <td class="text-row"> Pneumonia, respiratory failure
</td> <td class="text-row"> Lymphopenia,? thrombocytopenia??
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 4 days
</td> </tr> <tr> <td class="text-row" scope="row"> 22
</td> <td class="text-row"> 40 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Asthma, HTN, obesity
</td> <td class="text-row"> Pneumonia, respiratory failure
</td> <td class="text-row"> Leukocytosis,? anemia?
</td> <td class="text-row"> Bilateral infiltrates
</td> <td class="text-row"> Yes
</td> <td class="text-row"> Yes
</td> <td class="text-row"> None
</td> <td class="text-row"> Still hospitalized: day 18
</td> </tr> <tr> <td class="text-row" scope="row"> 23
</td> <td class="text-row"> 41 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Autoimmune hepatitis/biliary cirrhosis s/p liver transplant, HTN, obesity
</td> <td class="text-row"> Viral syndrome
</td> <td class="text-row"> Leukopenia,? anemia,? thrombocytopenia??
</td> <td class="text-row"> Unilobar infiltrate
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 6 days
</td> </tr> <tr> <td class="text-row" scope="row"> 24
</td> <td class="text-row"> 42 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Asthma, gastrointestinal reflux, pregnancy
</td> <td class="text-row"> Premature rupture of membranes, pre-eclampsia
</td> <td class="text-row"> None
</td> <td class="text-row"> Not done
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 4 days
</td> </tr> <tr> <td class="text-row" scope="row"> 25
</td> <td class="text-row"> 49 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> Aortic valve replacement, HTN, lupus nephritis, seizure disorder
</td> <td class="text-row"> Fever
</td> <td class="text-row">
</td> <td class="text-row"> Not available
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> Still hospitalized: day 15
</td> </tr> <tr> <td class="text-row" scope="row"> 26
</td> <td class="text-row"> 69 yrs
</td> <td class="text-row"> M
</td> <td class="text-row"> COPD, HTN, atrial fibrillation
</td> <td class="text-row"> Respiratory distress
</td> <td class="text-row"> Leukopenia?
</td> <td class="text-row"> Normal
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> Still hospitalized: day 13
</td> </tr> <tr> <td class="text-row" scope="row"> 27
</td> <td class="text-row"> 72 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> COPD, BOOP, DM, atrial fibrillation, HTN, chronic corticosteroid administration
</td> <td class="text-row"> Respiratory distress
</td> <td class="text-row"> Leukocytosis?
</td> <td class="text-row"> Unilobar infiltrate
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> None
</td> <td class="text-row"> 10 days
</td> </tr> <tr> <td class="text-row" scope="row"> 28
</td> <td class="text-row"> 73 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> COPD, HTN
</td> <td class="text-row"> Respiratory distress
</td> <td class="text-row"> Lymphopenia?
</td> <td class="text-row"> Normal
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> 3 days
</td> </tr> <tr> <td class="text-row" scope="row"> 29
</td> <td class="text-row"> 87 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> CAD, COPD, HTN, breast cancer
</td> <td class="text-row"> Pneumonia, respiratory failure
</td> <td class="text-row"> Leukocytosis,? anemia?
</td> <td class="text-row"> Bilateral infiltrates and pleural effusions
</td> <td class="text-row"> Yes
</td> <td class="text-row"> Yes
</td> <td class="text-row"> None
</td> <td class="text-row"> Still hospitalized: day 27
</td> </tr> <tr> <td class="text-row" scope="row"> 30
</td> <td class="text-row"> 89 yrs
</td> <td class="text-row"> F
</td> <td class="text-row"> Sjogren syndrome, pulmonary fibrosis, chronic corticosteroid administration, HTN
</td> <td class="text-row"> Not available
</td> <td class="text-row"> Leukocytosis,? positive D-dimer
</td> <td class="text-row"> Unilobar infiltrate
</td> <td class="text-row"> No
</td> <td class="text-row"> No
</td> <td class="text-row"> Oseltamivir
</td> <td class="text-row"> Still hospitalized: day 4
</td> </tr> <tr> <td class="footnote-row" colspan="11" scope="row"> * HTN: hypertension. COPD: chronic obstructive pulmonary disease. CAD: coronary artery disease. BOOP: bronchiolitis obliterans organizing pneumonia.
? Hematocrit <35%.
? Total leukocyte count >10 cells/mm3.
? Total lymphocyte count <800 cells/mm3.
** White blood cell count <5,000 cells/mm3.
?? Platelet count <150,000 cells/mm3.
</td> </tr> </tbody> </table>
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Date last reviewed: 5/18/2009

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[Niko]

Re: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

PDF of previous post
mm58e0518.pdf

[Farmer]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Of those 14 hospitalized persons < 21 years of age reported in this summery, six (43%) did not have an underlying risk factor for severe illness identified.

Pregnancy was cited as the sole underlying risk factor for two of the remaining 8 patients under 21 years of age.

[AlexanderSJones]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Nice find, this data is priceless. . . Good Lord , 15/25 have lung infiltrates...

So the best predictive symptoms based on this data are:

1) Fever (97&#37
2) Cough (77%)
3) Lung infiltrates (60%)
4) Vomiting (46%)
5) Shortness of breath (43%)

#3 and #4 are unusual for influenza

[Giuseppe]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Of those 14 hospitalized persons < 21 years of age reported in this summery, six (43%) did not have an underlying risk factor for severe illness identified.

Pregnancy was cited as the sole underlying risk factor for two of the remaining 8 patients under 21 years of age.

But four have less than a year of age.

[Giuseppe]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Nice find, this data is priceless. . . Good Lord , 15/25 have lung infiltrates...

So the best predictive symptoms based on this data are:

1) Fever (97%)
2) Cough (77%)
3) Lung infiltrates (60%)
4) Vomiting (46%)
5) Shortness of breath (43%)

#3 and #4 are unusual for influenza

The good news is that the most part of patient recovered quickly with short stay at hospital. A self-limiting pneumonia.

[AlexanderSJones]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Yes that is indeed good news that these patients recovered.

What concerns me is that perhaps these numbers will continue to increase, due to the exponential spread of the virus.

[wetDirt]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Yes that is indeed good news that these patients recovered.

What concerns me is that perhaps these numbers will continue to increase, due to the exponential spread of the virus.

Umm, but the bad news is that 7 are still hospitalized. That's a bit of a ways from recovered.

[hornblower]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Case #3 looks like hospital acquired.

Appears to be a premie with several associated problems and a long term stay in NICU. Infection control in NICU's is usually quite good so this is a concern.

[wotan]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Case #3 looks like hospital acquired.

Appears to be a premie with several associated problems and a long term stay in NICU. Infection control in NICU's is usually quite good so this is a concern.

Huh? While in NICU my daughter acquired (non MRSA) staph and pseudomonas aureuginosa (sp?) as both a UTI and lung colonization. Thankfully the latter was beat with aggressive use of tobramycin.

[wetDirt]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

http://www.pasadenastarnews.com/rds_search/ci_12380791?IADID=Search-www.pasadenastarnews.com-www.pasadenastarnews.com

PASADENA - Public health officials have announced the city's first probable case of swine flu - Influenza Type A H1N1.

Pasadena Public Health Department said Friday that an adult in the 40 to 50 age range had "mild symptoms" and was seen by a physician. Prescription medication was not necessary and officials said the patient has fully recovered.

The resident is no longer contagious, health officials said, and people who came in close contact have shown no symptoms.

Looks like Pasadena has finally gotten a case.

[Shiloh]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Source: http://www.washingtonpost.com/wp-dyn...051902609.html

Hospitalized Swine Flu Patients in Calif. Had Underlying Conditions
By David Brown and Robin Shulman
Washington Post Staff Writers
Tuesday, May 19, 2009; 5:07 PM

A survey of people hospitalized because of swine flu in California has found that obesity was almost as common in them as diabetes, heart disease and pregnancy, all conditions known to raise a person's risk of complications from influenza.

In all, about two-thirds of the patients had some underlying medical condition, according to a report today in the weekly bulletin of he Centers for Disease Control and Prevention.

"We were surprised by the frequency of obesity among the severe cases that we've been tracking," said Anne Schuchat, one of the CDC epidemiologists managing the swine flu outbreak.

She said the possibility that obese people should be at the head of the line along with other high-risk groups if a swine flu vaccine becomes available is something "we're looking into."

Some studies have shown that pregnant women are also at higher risk for serious influenza infection, especially in the third trimester when the fetus and womb compress the lower regions of the lungs. This makes it harder to breathe deeply and cough forcefully; it may also alter blood flow in the chest. A similar thing may be occurring in severely overweight people, some experts speculate.

The average age of the 30 Californians hospitalized for swine flu was 27.5 years. Nearly three-quarters were women and 65 percent were Hispanic. Half lived in two counties bordering Mexico.

Of the 30 people, 11 had a lung ailment such as asthma or emphysema, six had an immune disorder, five had heart disease, five were pregnant, four had diabetes, and four were obese.

Nationwide, 48 states reported 5,469 cases and six U.S. deaths since the start of the outbreak in late April.

In New York, Mayor Michael R. Bloomberg said today that officials are investigating whether 16-month-old Jonathan Castillo, who died with a high fever Monday night at a Queens hospital, had contracted the H1N1 virus. The toddler's 3-year-old sibling was treated for flu-like symptoms and released.

"Every parent in the city, myself included, can appreciate the grief the parents of these children are experiencing," Bloomberg said. "We don't yet know if the child who died had contracted the H1N1 virus. Tests will be performed at the city's health department lab to investigate that question."

"Whether you have health insurance coverage or your immigration status is in question, it doesn't matter," the mayor said. "We will not ask about that."

The mayor also said that four inmates at the city's Rikers Island jail had been confirmed to have the H1N1 virus, and four more are likely to have it.

The union representing the city's correctional officers criticized the response to the swine flu outbreak among inmates and filed a letter of protest with the Department of Labor, and possibly to file a lawsuit in state Supreme Court.

"If I had to design a place where you could put people who were sick and get as many people sick as possible, it's the New York City jail," said Richard J. Koehler, a lawyer for the Correction Officers' Benevolent Association.

"It is in some senses easier to control because, obviously, the prisoners can't leave," responded the mayor at the news conference. "On the other hand, it is also a confined area where we really don't have the choice of moving people out and asking them to stay home."

Also today, the private Horace Mann School in the Bronx announced that it would close at the end of the day because an unusually high number of students were ill and reopen after Memorial Day.

Shulman reported from New York.

[Shiloh]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

Source: http://www.medpagetoday.com/Infectio...SwineFlu/14283

Characteristics of Hospitalized Swine Flu Patients Revealed
By Todd Neale, Staff Writer, MedPage Today
Published: May 19, 2009

LITTLE FALLS, N.J., May 19 -- Fever, vomiting, pneumonia, and underlying health issues are all common findings in patients hospitalized with 2009 H1N1 (swine) flu, according to the CDC.

At latest count, there were 5,469 confirmed or probable cases of infection with the new virus in the U.S., with six deaths, but only a very small percentage have required hospitalization, the agency said.

To explore the characteristics of those who are need to be hospitalized, CDC researchers and public health officials from California examined all 30 patients admitted in that state as of May 17.

The cases spanned a wide range of ages -- from 29 days to 89 years (median 27.5 years) -- and spectrum of disease severity, according to the report presented in a Morbidity and Mortality Weekly Report early release.

All but one patient presented with fever. Other common symptoms included cough and shortness of breath.

Nearly half (46%) presented with vomiting, which is unusual for infection with seasonal influenza viruses, according Anne Schuchat, M.D., interim deputy director of the CDC's science and public health program. She discussed the MMWR report on a conference call with reporters.

Evidence of pneumonia was seen on lung X-rays of 60% of the hospitalized patients, 20% required admission to the intensive care unit, and 13% were placed on mechanical ventilation.

Only half received antiviral treatment with oseltamivir (Tamiflu).

Dr. Schuchat said the CDC is recommending that all patients hospitalized with the new H1N1 virus receive antiviral treatment, even if they are admitted more than 48 hours after symptom onset.

Nearly two-thirds (64%) of the patients had at least one underlying medical condition that put them at risk for complications from the flu.

These conditions included chronic lung disease, conditions associated with immunosuppression, chronic heart disease, diabetes, and obesity.

"We were surprised by the frequency of obesity among the severe cases that we have been tracking," Dr. Schuchat said. "The question of whether people with obesity need to be treated differently in terms of antiviral treatment or our seasonal flu vaccine recommendations, for instance, is one that we're looking into right now."

Five of the women who were hospitalized were pregnant and two developed complications -- spontaneous abortion and premature rupture of the membranes.

Pregnancy is a risk factor for worse complications from flu, Dr. Schuchat said, and antivirals are "probably appropriate" for treating pregnant women.

Although none of the patients had died, seven remained in the hospital as of May 17.

[Rocky]

Re: MMWR: California Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection, April--May, 2009

I see many of the states have changed to weekly reporting instead of Daily, California is one of them...

last update May 15th