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Influenza A(H1N1) virus resistance to oseltamivir - 2008 influenza season, southern hemisphere
Influenza A(H1N1) virus resistance to oseltamivir - 2008 influenza season, southern hemisphere
22 September 2008
During the weeks 33?36 (10 August ? 6 September), overall influenza activity in the southern hemisphere declined, except for New Zealand where influenza activity remained widespread with
predominating influenza B virus and co-circulating A(H3) virus.
In Australia, local activity was reported during weeks 35-36 with co-circulation of A and B viruses.
Between weeks 33 to 36, in the southern hemisphere, sporadic influenza activity was detected in Argentina (A,B), Brazil (A), Chile (B, A) and New Caledonia (H1). Activity was low in the rest of the world ? declining influenza activity (H1, H3) was reported from Hong Kong SAR, China and only sporadic influenza activity was reported from Canada (H1, B) and Japan (H3).
WHO has received several reports from National Influenza Centres (NIC) in the southern hemisphere regarding influenza A(H1N1) virus resistance to oseltamivir.
In South Africa, a total of 283 A(H1N1) viruses have been isolated during the 2008 influenza season as of 9 September.
Of those, 129 isolates have been tested for oseltamivir resistance by the National Institute of Communicable Diseases (NICD) and 100% were found to be resistant to oseltamivir by genotypic
analysis.
Only one of these 129 patients was receiving oseltamivir at the time of sampling, and no unusual clinical features or underlying conditions were found.
In Australia, 25 of 26, Argentina, 11 of 25, Chile, 6 of 44 A(H1N1) viruses analysed showed the specific neuraminidase mutation (H274Y) associated with oseltamivir resistance, respectively.
WHO has also received reports from NICs in other parts of the world; In the Russian Federation, 9 of 20, and Philippines, 10 of 11 A(H1N1) viruses tested were found to be resistant, respectively.
WHO is collecting global data about this phenomenon from multiple laboratories participating in Global Influenza Surveillance Network. Data from European countries participating in EISS were
provided by the EISS and VirGil project. This summary table will be updated regularly (every four weeks).
Oseltamivir resistance results were based on phenotypic and/or genotypic analyses.
For background and summary until week 24, 2008, see Influenza A(H1N1) virus resistance to oseltamivir, Last quarter 2007 to first quarter 2008, Preliminary summary and future plans
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Shot at 2008-09-29
Shot at 2008-09-29
Shot at 2008-09-29
Shot at 2008-09-29
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Influenza A(H1N1) virus resistance to oseltamivir - 2008 influenza season, southern hemisphere
22 September 2008
During the weeks 33?36 (10 August ? 6 September), overall influenza activity in the southern hemisphere declined, except for New Zealand where influenza activity remained widespread with
predominating influenza B virus and co-circulating A(H3) virus.
In Australia, local activity was reported during weeks 35-36 with co-circulation of A and B viruses.
Between weeks 33 to 36, in the southern hemisphere, sporadic influenza activity was detected in Argentina (A,B), Brazil (A), Chile (B, A) and New Caledonia (H1). Activity was low in the rest of the world ? declining influenza activity (H1, H3) was reported from Hong Kong SAR, China and only sporadic influenza activity was reported from Canada (H1, B) and Japan (H3).
WHO has received several reports from National Influenza Centres (NIC) in the southern hemisphere regarding influenza A(H1N1) virus resistance to oseltamivir.
In South Africa, a total of 283 A(H1N1) viruses have been isolated during the 2008 influenza season as of 9 September.
Of those, 129 isolates have been tested for oseltamivir resistance by the National Institute of Communicable Diseases (NICD) and 100% were found to be resistant to oseltamivir by genotypic
analysis.
Only one of these 129 patients was receiving oseltamivir at the time of sampling, and no unusual clinical features or underlying conditions were found.
In Australia, 25 of 26, Argentina, 11 of 25, Chile, 6 of 44 A(H1N1) viruses analysed showed the specific neuraminidase mutation (H274Y) associated with oseltamivir resistance, respectively.
WHO has also received reports from NICs in other parts of the world; In the Russian Federation, 9 of 20, and Philippines, 10 of 11 A(H1N1) viruses tested were found to be resistant, respectively.
WHO is collecting global data about this phenomenon from multiple laboratories participating in Global Influenza Surveillance Network. Data from European countries participating in EISS were
provided by the EISS and VirGil project. This summary table will be updated regularly (every four weeks).
Oseltamivir resistance results were based on phenotypic and/or genotypic analyses.
For background and summary until week 24, 2008, see Influenza A(H1N1) virus resistance to oseltamivir, Last quarter 2007 to first quarter 2008, Preliminary summary and future plans
-
-----
Shot at 2008-09-29
Shot at 2008-09-29
Shot at 2008-09-29
Shot at 2008-09-29
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