Reassortment of pandemic H1N1/2009 influenza A virus in swine

[tetano]

Science. 2010 Jun 18;328(5985):1529.
Reassortment of pandemic H1N1/2009 influenza A virus in swine.

Vijaykrishna D, Poon LL, Zhu HC, Ma SK, Li OT, Cheung CL, Smith GJ, Peiris JS, Guan Y.

State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
Abstract

The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.

PMID: 20558710 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/20558710

[tetano]

Re: Reassortment of pandemic H1N1/2009 influenza A virus in swine

Vol. 304 No. 6, August 11, 2010 TABLE OF CONTENTS
JAMA
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Medical News & Perspectives


H1N1 Influenza Virus Reassorting in Pigs, Poses Unknown Risk to Human Health

Mike Mitka

JAMA. 2010;304(6):626-627. doi:10.1001/jama.2010.1056


Pandemic 2009 influenza A(H1N1) virus, which spread to more than 200 countries worldwide, has undergone genetic reassortment in pigs over the last year and a half, report researchers from Hong Kong and China. This reassortment, they say, should serve as a warning that increased surveillance of swine is vital for minimizing consequences should a variant influenza strain emerge that poses a risk to human and animal health.

In a report released June 17, the researchers said that they had identified a novel genetic reassortant in January and confirmed that it arose from the 2009 influenza A(H1N1) virus. They could not say if this reassortant . . .

http://jama.ama-assn.org/cgi/content/extract/304/6/626