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  • #16
    Re: Egyptian girl dies of bird flu / mother also in hospital

    Nadi's mother also sick and in hospital in Cairo...

    Egypt Teenage Girl Dies of Bird Flu
    Jano Charbel & Agencies

    CAIRO, 7 February 2007 ? A teenage girl became the fifth Egyptian to die of bird flu in six weeks, a health official said yesterday, amid fears of a global surge in infections by the deadly virus. Nour Nadi, a 17-year-old from the impoverished oasis province of Fayyum, 100 kilometers south of the capital, died Monday of the H5N1 strain of avian influenza.

    Nadi?s mother, Marzouqa Ramadan, who may have caught the virus from her daughter, was said to have been admitted to a respiratory illnesses hospital in the Al-Abbasiya district of Cairo, on the same day, where she is being examined by doctors.

    The World Health Organization?s John Jabbour said the girl died of the normal strain of the virus rather than a new drug-resistant variety. Of the 20 people diagnosed with the virus since it was first detected in Egypt in 2006, eight have survived, but the mortality rate increased after the emergence of what the WHO said was a more virulent strain late last year.

    ?In the last case in Beni Sueif (province), it had turned back to the normal strain and we expect this one to be the same,? said Jabbour about Nadi?s death. In January, the WHO announced that people had died of bird flu in the Nile Delta province of Gharbiya, north of Cairo, after the virus mutated into a strain resistant to the common Tamiflu treatment.

    Subsequent tests in the same and other areas have not shown the presence of the drug-resistant strain. ?The Gharbiya strain has died off and we are back to the normal strain,? Jabbour told AFP. Nadi died not because her infection was drug-resistant, he added, but because she tried to hide her symptoms from discovery because of the growing stigma surrounding the disease.

    In another development, Egyptian President Hosni Mubarak ordered members of the opposition Muslim Brotherhood, including the group?s number three, to stand trial before a military court, officials said yesterday.

    ?The president of the republic has ordered that leading Muslim Brotherhood member Khayrat Al-Shater and others be tried before a military court,? the source said, without specifying how many co-defendants faced trial.

    Shater, the movement?s main financier, is part of a group of 29 Brotherhood members whose assets were frozen by the state last month on charges of money laundering and financing illegal activities. ?It is a cruel decision and it is a political one,? the Brotherhood?s deputy supreme guide Mohammed Habib told AFP.

    Established in 1975, the Saudi-based Arab News is the Middle East’s newspaper of record and the biggest English language daily in the Kingdom.
    ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

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    • #17
      Re: Egyptian girl dies of bird flu / mother also in hospital

      Report of Nadi's mother being hospitalized from the Egyptian government's bf website...

      Google-translated from Arabic:

      The death of the 12th contracted avian flu
      Feb 6, 2007

      The Ministry of Health announced yesterday 2-5-2007 for the death of Miss Nu OL Club [Nour Nadi] of Fayoum 17 years after his [her] illness will Aspatha Unza for birds.

      This is a case of death No. 12 of the total 20 injured Bal since the disease appeared in the last year. [R]eceived a Hospital Abbasiya yesterday 2-5-2007 Ms. sisters, the father [mother] of Ramadan [Marzouqa Ramadan] e deceased girl on suspicion of the disease infected Otj Ri procedures required analysis.

      ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

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      • #18
        Re: Egyptian girl dies of bird flu / mother also in hospital

        Commentary at

        Comment


        • #19
          Re: Egyptian girl dies of bird flu / mother also in hospital

          Mother of Sixth Qinghai H5N1 Fatality in Egypt is Hospitalized
          Recombinomics Commentary
          February 7, 2007

          A teenage girl became the fifth Egyptian to die of bird flu in six weeks, a health official said yesterday, amid fears of a global surge in infections by the deadly virus. Nour Nadi, a 17-year-old from the impoverished oasis province of Fayyum, 100 kilometers south of the capital, died Monday of the H5N1 strain of avian influenza.

          Nadi?s mother, Marzouqa Ramadan, who may have caught the virus from her daughter, was said to have been admitted to a respiratory illnesses hospital in the Al-Abbasiya district of Cairo, on the same day, where she is being examined by doctors.


          The above translation describes the hospitalization of the mother of the most recent confirmed H5N1 case in Egypt. The recent case (17F) was the sixth fatal case this season in Egypt. If the mother is positive for H5N1, then five of the seven cases in Egypt will be from clusters. Sequences of H5N1 from the first three cases have M230I, which is also likely in the third Gharbiya cluster member. This change, which is adjacent to the receptor binding domain, is also in seasonal flu (H1N1, H3N2, influenza B). It has also been found in H5N1 from birds in Egypt, although it is encoded with sequences found in H5N1 as well as H7N3.

          More information on the sequences of the recent confirmed cases as well as testing of her hospitalized mother would be useful.

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          • #20
            Re: Egyptian girl dies of bird flu / mother also in hospital

            Nadi's mother, father(?) and sisters reportedly test neg. Hat-tip, UK-Bird!

            Google-translated from Arabic:

            [Headline not available]
            Feb 7, 2007

            Cairo-MENA-Dr Abdel Rahman Shahin hurt event official spokesman of the Ministry of Health. The results of the analysis of the girl's mother, "Nuri Club," died Monday in Fayyoum result of presence of avian flu was negative.
            The spokesman - in response to rumors about the injury the girl's mother Nouri, or a member of her family Banfelonz a bird "that the results of the analysis of his father [mother?], the girl negative, in addition to the results of the analysis of all Almkhalten girls also negative."


            It is noteworthy that Nouri Club is the case of the 12 died avian influenza coordinates of the total 20 cases of human hit since the disease appeared in Egypt last March, but so far between what has been recovered from all the other eight cases.

            http://www.masrawy.com [Permalink to article unfortunately not available.]
            ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

            Comment


            • #21
              wild bird links or?

              Originally posted by Mellie View Post
              Wild Bird Linkage with H5N1 Positive Case in Jakarta
              Recombinomics Commentary
              February 6, 2007


              [COLOR=#000000]In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.

              ``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.

              The above comments provide a link between a confirmed H5N1 case (15F) in Jakarta with a wild bird. The girl lived in an upscale neighborhood in Jakarta, and the failure to link the case to domestic poultry is similar to the circumstances surrounding first H5N1 cluster in Tangerang, adjacent to Jakarta.

              snip...

              COLOR]
              This and the Egyptian girl who also claimed infection by wild bird don't sound quite right. In both cases, the consequence of mentioning a poultry source causes all the poultry/kept birds in the area to be slaughtered, and attaches a social stigma. I'd rather just compare sequences, and not pay much attention to what people claim as a source of infection. There are too many reasons people may mistake or misstate the source. Let the data decide.

              Comment


              • #22
                Re: Egyptian girl dies of bird flu / mother also in hospital

                Egyptian authorities weren't able to detect H5N1 from Nadi's samples? It was NAMRU that confirmed her?

                Google-translated from Arabic:

                Three stories of the death of the victim No. 12 of avian flu
                Feb 7, 2007
                Wrote Tariq Amin and meet Bakri Mohamed Farghali

                With the formal announcement of the death of the victim No. 12 Banfelonz a bird in the province of Fayoum, It Nora Club <17 years>, There were several accounts of the cause of death.

                Dr. Hussein Abutalb Sophie, Undersecretary of the Ministry of Health in Fayyoum, l <Egyptian today>: Different sampling results from the girl suffered the death of confirming <turn of the virus>.

                He pointed to inconsistencies Abutalb which happened in the case <Nora> between the results of laboratory tests conducted by the Center Yeh to the Ministry of Health for the disease, and the results of the sample sent to the laboratory of <Alenamro> [NAMRU] group of the American navy, He said that the results of the analysis of the negative health factor, While the results of the analysis <Alenamro> [NAMRU] positive pressed him.

                In the official version again, Dr. Amr Qandil, head of the Central Administration did not Fights infection in the Ministry of Health: that <Nora> died four days ago [i.e. Feb 2], two days before the formal announcement of her death as a result deciding H5N1 avian influenza, in accordance with the assurances by the Ministry of Health and World Health Organization e.

                The Qandil told <Egyptian today> that Nora underwent treatment in one of the private clinics in Fayoum, pointing out that the doctor as a condition <Tivoed> on Aat Parr did not disclose to the doctor for Mkhalttha birds.

                And turn around and the different symptoms of the virus than ever before, Ahmed al-Hadidi, professor of chest diseases at Cairo University, that the symptoms did not differ, He pointed out that the problem is to resist the virus Ela Qar <Altamiflo> [in Nadi??]. He explained that the symptoms are new pneumonia pain Zdoj, and the water on the lung, and brain inflammation, in addition to the eye and throat inflammation and asthma.

                ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                Comment


                • #23
                  Re: Egyptian girl dies of bird flu / mother also in hospital

                  Originally posted by Theresa42
                  Egyptian authorities weren't able to detect H5N1 from Nadi's samples? It was NAMRU that confirmed her?

                  Google-translated from Arabic:

                  Three stories of the death of the victim No. 12 of avian flu
                  Feb 7, 2007
                  Wrote Tariq Amin and meet Bakri Mohamed Farghali

                  With the formal announcement of the death of the victim No. 12 Banfelonz a bird in the province of Fayoum, It Nora Club <17 years>, There were several accounts of the cause of death.

                  Dr. Hussein Abutalb Sophie, Undersecretary of the Ministry of Health in Fayyoum, l <Egyptian today>: Different sampling results from the girl suffered the death of confirming <turn of the virus>.

                  He pointed to inconsistencies Abutalb which happened in the case <Nora> between the results of laboratory tests conducted by the Center Yeh to the Ministry of Health for the disease, and the results of the sample sent to the laboratory of <Alenamro> [NAMRU] group of the American navy, He said that the results of the analysis of the negative health factor, While the results of the analysis <Alenamro> [NAMRU] positive pressed him.

                  In the official version again, Dr. Amr Qandil, head of the Central Administration did not Fights infection in the Ministry of Health: that <Nora> died four days ago [i.e. Feb 2], two days before the formal announcement of her death as a result deciding H5N1 avian influenza, in accordance with the assurances by the Ministry of Health and World Health Organization e.

                  The Qandil told <Egyptian today> that Nora underwent treatment in one of the private clinics in Fayoum, pointing out that the doctor as a condition <Tivoed> on Aat Parr did not disclose to the doctor for Mkhalttha birds.

                  And turn around and the different symptoms of the virus than ever before, Ahmed al-Hadidi, professor of chest diseases at Cairo University, that the symptoms did not differ, He pointed out that the problem is to resist the virus Ela Qar <Altamiflo> [in Nadi??]. He explained that the symptoms are new pneumonia pain Zdoj, and the water on the lung, and brain inflammation, in addition to the eye and throat inflammation and asthma.

                  http://www.almasry-alyoum.com/articl...leID=47256&r=t
                  Another translation...

                  Three narrations of the victim's death of a number 12 to the bird flu
                  Feb 7, 2007

                  With the declaration officially about the victim's death of a number 12 by the bird flu in Al Fayum Governate, and she "a light a club" [Nouri Nadi] 17 a year, several novels [stories] appeared to the death reasons.

                  Doctor Hussein Sophie Aboutalb, the Ministry of Health deputy in Al Fayyum, said to "The Egyptian Today": that the difference of the results of the taken samples from the dead girl "a change to the virus" confirms an occurrence.

                  And Abu Taleb pointed to the conflict that happened in a condition "a light" [Nouri] between the analyses results that the central laboratories held to the Ministry of Health to its disease, and between the sample results sent to the laboratory of "Namro" belonging to the American navy, and it said that the health laboratories analyses results came a passivity [negative], while analyses results confirmed "Namro" the positivity of condition.

                  And in another official novel [story], doctor Amr Qandil the central department president for Al Adawi's fighting in the Ministry of Health said: "A light" [Nouri] was dead before 4 days, any before two days of the declaration officially about its death due to their injury by the bird flu virus, according to the confirmations of Ministry of Health and World Health Organization.

                  And Qandil confirmed to "The Egyptian Today" that a light [Nouri] was submitted to the treatment in one of the special clinics in Al Fayyum, explaining that the doctor is its condition person that it is "a typhoid" [i.e. they diagnosed her as having typhoid] considering that it did not reveal to the doctor its mixing the birds.

                  And around the change of virus and the difference of its symptoms about a before, confirmed doctor Ahmed Al Hadidi the professor of the chest diseases in the Cairo University, the symptoms did not differ, pointing out that the problem became in the resistance of virus to the drug of "Al Tamiflou". And he explained that the new [?] symptoms are the double pneumonia, and waters on the lung, and an inflammation in the brain, to the side of ophthalmia and throat and the dyspnea.
                  ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                  Comment


                  • #24
                    Re: Egyptian girl dies of bird flu / mother also in hospital

                    Hat-tip, highflyer!

                    An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
                    8 February 2007

                    Case Number: 20
                    Age: 17 years
                    Sex: female
                    Governorate: Fayoum

                    Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.

                    Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007 with fever and difficulty in Breathing.

                    Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.

                    Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.

                    Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.

                    Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

                    http://www.emro.who.int/ [<< prolly not a permalink]
                    ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                    Comment


                    • #25
                      Re: Egyptian girl dies of bird flu / mother also in hospital

                      Originally posted by Theresa42 View Post
                      Hat-tip, highflyer!

                      An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
                      8 February 2007

                      Case Number: 20
                      Age: 17 years
                      Sex: female
                      Governorate: Fayoum

                      Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.

                      Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007 with fever and difficulty in Breathing.

                      Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.

                      Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.

                      Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.

                      Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

                      http://www.emro.who.int/ [<< prolly not a permalink]
                      Sequence is similar to Beni Suef, but also has S227N.

                      Comment


                      • #26
                        Re: Egyptian girl dies of bird flu / mother also in hospital

                        Originally posted by niman View Post
                        Sequence is similar to Beni Suef, but also has S227N.
                        Beni Suef (aka Bani Suwayf) and Al Fayyum (Fayoum) are neighboring governorates:

                        Bani Suwayf Governorate:


                        Al Fayyum Governorate:
                        ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                        Comment


                        • #27
                          Re: Egyptian girl dies of bird flu / mother also in hospital

                          Originally posted by Theresa42
                          Beni Suef (aka Bani Suwayf) and Al Fayyum (Fayoum) are neighboring governorates:

                          Bani Suwayf Governorate:


                          Al Fayyum Governorate:
                          http://en.wikipedia.org/wiki/Al_Fayyum_Governorate
                          Warda Eid Ahmed, the case from Bani Suwayf, was from (I think) near Hillyah in Bani Suwayf governorate [source].

                          Nouri Nadi, the case from Al Fayyum governorate, was from Al Fayyum city [source].

                          These are ca. 30 miles away from each other (as the crow flies) -- (map of Hillyah).

                          Click image for larger version

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                          ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                          Comment


                          • #28
                            Re: Egyptian girl dies of bird flu / mother also in hospital

                            Commentary at

                            Comment


                            • #29
                              Re: Egyptian girl dies of bird flu / mother also in hospital

                              Originally posted by niman View Post
                              Commentary

                              S227N Re-emerges in Qinghai H5N1 in Egypt
                              Recombinomics Commentary
                              February 9, 2007


                              NAMRU-3 has generated HA and NA sequences from H5N1 from the recent confirmed case in Fayyoum. These sequences are very similar to the HA and NA sequences from A/Egypt/0636-NAMRU3/2007 from the patient in nearby Beni Suef. Like the earlier HA sequence, there is a 3 BP deletion in the recent isolate.

                              However, the HA sequence was a mixture that included S227N, which is linked to increased affinity for human receptors.

                              S227N was first reported in both isolates from a family in Hong Kong who had gone to Fujian province for a visit in early 2003. The daughter died in China with bird flu symptoms and H5N1 was isolated from the father and son in Hong Kong. The father died, but both isolates (on MDCK cells from dog kidney) had S227N. A screening of H5N1 isolates in a receptor binding assay identified these two isolates as having increased affinity for 2,6 gal and decreased affinity for 2,3 gal.

                              Donor sequences for the acquisition of S227N in Qinghai H5N1 were present in H9N2 isolate that were almost exclusively in the Middle East. A warning was issued October 22, 2005 before Qinghai H5N1 had been confirmed in any human. S227N was then found in the index case for Turkey in early 2006. However, it was not in the isolate from his sister. Two additional sequences have been released, and S227N was in one of the two. Thus, S227N was in two of the four HA sequences from patients in Turkey, but in only one of the two siblings.

                              S227N was also in an human isolate from Egypt last year and S227N was found in an additional patient in Vietnam. However, the published data from a patient in Vietnam showed that S227N was in only one of three clones from that patient (all isolated with MDCK cells), indicating that patients with S227N had mixtures, and detecting S227N was most easily accomplished by looking at multiples clones from the same patient.

                              The latest sequence also is a mixture at the position encoding S227N. One sequence is wild type (with an A) while the other codes for S227N (with a G).

                              Although recent papers indicate H5N1 can be found in the upper respiratory tract, even when the binding preference is 2,3, sequences with a 2,6 preference lead to more sneezing (in ferrets described in Science), providing a mechanism for easier transmission. Thus, samples with S227N are more likely to lead to larger human clusters

                              S227N in Qinghai isolates from two patients in Turkey as well as two patients in Egypt indicates this receptor binding domain change is a major concern for the region.


                              .
                              "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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                              • #30
                                Re: Egyptian girl dies of bird flu / mother also in hospital

                                An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
                                8 February 2007

                                Case Number: 20
                                Age: 17 years
                                Sex: female
                                Governorate: Fayoum
                                Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.
                                Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007with fever and difficulty in Breathing.
                                Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.
                                Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.
                                Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.
                                Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

                                http://www.emro.who.int/

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