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Many patients 3 times still testing positive for A/H1N1

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  • Many patients 3 times still testing positive for A/H1N1

    Vietnam: Many patients 3 times still testing positive for A/H1N1

    Vietnamnet - 36 minutes ago

    The treatment of influenza A/H1N1 in Vietnam has recorded the patient's treatment time longer unusual, then many times the test is positive for influenza virus A/H1N1.
    Dak Lak province in a patient is admitted and have positive results for influenza A/H1N1 from 24 / 7. Treated properly exposed it after 5 days, the test on 29 / 7, the result is not negative. 2 days later, patients continue to be tested and continue positive.

    "This is the first patient to test the 4 th, after almost 10 days with new negative influenza virus A/H1N1," Mr. Tran Quy Tuong, Deputy Director General Management treatment (Ministry of Health ) said.

    In Tien Giang, 5 patients with influenza A/H1N1 also fell into a similar situation.

    Mr. Trinh Quan Huan, Deputy Minister of Health explained: "Previously, when other types of flu appear (H5N1, H3N2, influenza B), we have used to treat tamiflu. Frequency use tamiflu more likely resistance tamiflu growing. "

    Huan He also suggested the primary treatment should reserve Zanamivir filled rooms where a patient's resistance to flu drug Tamiflu. There is still the drug Tamiflu characteristics of the most popular in the treatment of influenza A/H1N1.

    According to Nguyen Tran Hien, Director of Institute of hygiene and epidemiology on the central world has 3 vaccine virus A/H1N1 flu tamiflu resistance. "At the vaccine virus A/H1N1 flu in Vietnam is still stable, no changes dị time. The length of treatment such as mentioned above still negative after continued use of tamiflu, " he said Hien.

    2 Chinese workers working in Vietnam and infected with influenza A/H1N1
    Hoang Dinh Hoan, Director of the Department of Health Lang Son province, said: "today, we discovered there are 2 workers in China to work in projects international venture, construction of good fun , the golf course (under Hoang Dong commune, City Lang Son) are high fever, cough and nearly 38 degrees. "

    Department of Health does Lang Son province has sent samples of 2 patients subject workers down about this and epidemiology central to testing.
    2 projects where workers are working there are people working. Mr. Hoan said medical center for Lang Son province has khử tr?ng spray the entire project area and isolation of people who have close contact with 2 people this, to prevent disease spread and development of new disease.

    On 7 / 8, Vietnam has recorded 35 more cases positive for influenza A/H1N1. In the south: 18 ca, north: of 8, Central 4 ca, Environment: 5 ca.
    Thus, up to 17h on 7 / 8, Vietnam has recorded 1,078 cases of positive, 1 deaths.

    Number of patients was 628 members. 449 remaining cases are being isolation, treatment at hospitals, treatment facilities, monitoring community health status is stable, without serious complication.

  • #2
    Re: Many patients 3 times still testing positive for A/H1N1

    <TABLE id=apex_layout_271110100662109808 class=formlayout summary=""><TBODY><TR><TD noWrap align=left>09-AUG-2009</TD></TR><TR><TD noWrap align=right>Subject</TD><TD noWrap align=left>PRO/AH/EDR> Influenza pandemic (H1N1) 2009 (27): Viet Nam, patient data update</TD></TR></TBODY></TABLE>

    INFLUENZA PANDEMIC (H1N1) 2009 (27): VIET NAM, PATIENT DATA UPDATE******************************************** **********************Date: Sat 8 Aug 2009From: Rogier van Doorn <rvandoorn@oucru.org> [edited]In the Hospital for Tropical Diseases [HTD] in Ho Chi Minh City, Viet Nam, patients with flu symptoms and a positive real time polymerase chain reaction (RT-PCR) result for influenza pandemic H1N1 2009 virus infection using the CDC assay (inc. specific A(H1N1)v primers/probe) are hospitalized and treated with oseltamivir (75 mg twice daily) until RT-PCR results are negative.We previously reported clinical data and results of daily RT-PCR testing on the 1st 44 patients identified during the influenza pandemic (H1N1) 2009 virus outbreak [see ProMED-mail Influenza pandemic (H1N1) 2009 - Viet Nam: patient data, archive number 20090708.2450]. These results indicated that the majority of patients had resolved infection by day 2 post admission. 8 patients still had a positive PCR at day 3, 8 patients had a positive PCR at day 4, and all were RT-PCR negative by day 5 of sampling.Subsequently, we have conducted culture attempts on all samples from the 13 patients that remained RT-PCR positive until day 3 or 4 using MDCKSiat1 cells in a 6-well plate format, with 3 passage attempts per specimen. Replicating virus was recovered from 91 percent (10/11) of day 0 samples; 55 percent (6/11) of day 1 samples; 31 percent (4/13) of day 2 samples; 46 percent (6/13) of day 3 samples; and [29] percent (2/7) of positive day 4 samples.In addition, we have observed a small number of patients that remained RT-PCR positive for an extended period of time, despite receiving a full course of oseltamivir treatment (5d of 75 mg twice daily). Notably, among a total of 297 H1N1 cases diagnosed at HTD to date (as of 6 Aug 2009), 2 patients remained RT-PCR positive until day 6, one until day 10, one until day 11, and one until day 12 after diagnosis/admission to our hospital. However, culture attempts were negative from all patient specimens collected more than 5 days post-admission. A neuraminidase inhibition assay was performed on 23 specimens from 16 patients who had a positive PCR at day 3 or later, and all were found to be fully sensitive to oseltamivir. In addition, sequencing of selected 1st and last positive specimens from these patients has failed to reveal presence of the oseltamivir resistance marker NAH274Y.Our results show that among these 1st 44 influenza pandemic (H1N1) 2009 virus infected patients diagnosed in Ho Chi Minh City, favorable clinical and RT-PCR responses were observed. For most patients with prolonged RT-PCR positive results, replicating virus disappeared before RT-PCR became negative. Most importantly, among a total of 297 patients no virus was cultured after 5 days of treatment and no resistance associated mutations were detected.--Juliet BryantTran Tinh HienNguyen Thanh TruongNguyen Van Vinh ChauJeremy FarrarRogier van DoornHospital for Tropical DiseasesSouth East Asia Infectious Disease Clinical Research NetworkOxford University and Wellcome Trust Major Overseas Programme190 Ben Ham Tu, District 5Ho Chi Minh CityViet Nam<rvandoorn@oucru.org>[The outcome of this survey is reassuring in that routine oseltamivir treatment did not result in selection of resistant mutants even in those patients shedding virus for the longest period. - Mod.CP]http://www.promedmail.org/pls/otn/f?..._ID:1000,78714</PRE>
    CSI:WORLD http://swineflumagazine.blogspot.com/

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