Denmark - Dane with novel H1N1 found resistant to Tamiflu

[Gert van der Hoek]

caution - google translated

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark.


Dane resistant to Tamiflu

29. June 2009

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark.

The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

http://www.dr.dk/Nyheder/Indland/2009/06/29/151411.htm?rss=true

[tropical]

Re: Denmark - H1N1 found resistant to new H1N1

Hi Dutchy,

could you please confirm that this is an "swine" flu pandemic AH1N1 Tamiflu resistance?

[Gert van der Hoek]

Re: Denmark - H1N1 found resistant to new H1N1

Original in Danish:

Det f?rste tilf?lde i verden af resistens over for influenza-medicinen Tamiflu hos folk med influenza H1N1 er fundet i Danmark.


Dansker resistent over for Tamiflu

29. jun. 2009 15.20 Indland Opdat.: 29. jun. 2009 15.32

Det f?rste tilf?lde i verden af resistens over for influenza-medicinen Tamiflu hos folk med influenza H1N1 er fundet i Danmark.

Personen er nu rask, og der er ikke p?vist yderligere smitte med det resistente virus, oplyser Statens Serum Institut.

It says "the first in the world' ; if it was "normal" of seasonal H1N1 the man would not be the first one in the world.

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Update:

Dane resistant to Tamiflu

29. June 2009 15.20 Inland update.: 29 June 2009 15.38

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark.

The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

The infection had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu. Yet the person had flu symptoms and are instead treated with another type of flu drugs, Relenza.

Mutated virus in Denmark

World Health Organization Calls for the Danish case for more attention to the possibility of development of resistance in the virus.

It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected."

They also emphasized that it does not pose a threat to public health.

http://translate.google.com/translate?u=http://www.dr.dk/Nyheder/Indland/2009/06/29/151411.htm?rss=true&sl=da&tl=en

[HenryN]

Re: Denmark - H1N1 found resistant to new H1N1

Hi Dutchy,

could you please confirm that this is an "swine" flu pandemic AH1N1 Tamiflu resistance?

Tamiflu resistance is fixed in seasonal H1N1 and has been for some time. Resistance in SWINE H1N1 would be a first (and news).

[HenryN]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Update:

Dane resistant to Tamiflu

29. June 2009 15.20 Inland update.: 29 June 2009 15.38

It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected."

They also emphasized that it does not pose a threat to public health.

http://translate.google.com/translat...ue&sl=da&tl=en

Well beyond head pats.

"Spontaneous mutation" indicates this was not due to reassortment with seasonal H1N1 (and is likely due to acquisition of H274Y by recombination with seasonal flu, although precise polymorphisms is not stated).

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Dane resistant to pandemic medicine

/ Ritzau /

Last updated on Monday 29th June 2009, 15:30

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark. The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

The infection had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu. Yet the person had flu symptoms and are instead treated with another type of flu drugs, Relenza. World Health Organization Calls for the Danish case for more attention to the possibility of development of resistance in the virus.

It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected." They also emphasized that it does not pose a threat to public health. /

http://www.horsens-folkeblad.dk/?rartikel=K2JN-7TGHD8201175

[sharon sanders]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Yes! Huge news. Thanks Dutchy.

Is there any chance that the writer or editor of this article does not understand the issues and is mis-stating the situation?

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

May be someone who knows more about these things than me can contact them:

CONTACT SSI


Statens Serum Institut
5, Artillerivej
DK-2300 Copenhagen S
Denmark

Phone: +45 3268 3268
Fax: +45 3268 3868
VAT No. 46 83 74 28
EAN: 5798000362192
serum@ssi.dk

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Dane resistant to pandemic medicines

29. June 2009 15:30

pandemic flu virus H1N1 has been found in Denmark in a mutated version that is resistant to Tamiflu, which is usually used in the treatment of flu .

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark. The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

The infection had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu. Yet the person had flu symptoms and are instead treated with another type of flu drugs, Relenza.

World Health Organization Calls for the Danish case for more attention to the possibility of development of resistance in the virus.

It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected."

They also emphasized that it does not pose a threat to public health.

http://www.kristeligt-dagblad.dk/artikel/329568:Danmark--Dansker-resistent-over-for-pandemimedicin

[HenryN]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

May be someone who knows more about these things than me can contact them:

CONTACT SSI


Statens Serum Institut
5, Artillerivej
DK-2300 Copenhagen S
Denmark

Phone: +45 3268 3268
Fax: +45 3268 3868
VAT No. 46 83 74 28
EAN: 5798000362192
serum@ssi.dk

I didn't see anything on their website. However, if the patients was NOT treated with Tamiflu, then the polymorphism (likely H274Y) was NOT selected and the virus with the change is fit.

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Dane first with H1N1-mutation

29. June 2009 15:58 A Dane has developed a mutated version of H1N1 that are resistant to influenza agent Tamiflu. This is the first identified mutation of H1N1 in the world

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark. The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

- We do not expect that it exists long, says Nils Strandberg Pedersen, Managing Director, Statens Serum Institut, and refers to the mutated form of H1N1.

The infected Dane had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu. Yet the person had flu symptoms and are instead treated with another type of flu drugs, Relenza.

According to Niels Strandberg Pedersen, it is not significant that the first mutated version is found in Denmark.

- We see it as an expression of our monitoring work, he said.

World Health Organization Calls for the Danish case for more attention to the possibility of development of resistance in the virus.

It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected." At the same time, Niels Strandberg Pedersen not exclude that there will be new forms of mutation.

For the treatment of H1N1, Denmark has large stockpiles of Tamiflu, and in late April were purchased 40,000 doses of Relenza for additional security in cases of resistant mutations.

http://www.kristeligt-dagblad.dk/artikel/329568:Danmark--Dansker-den-foerste-med-H1N1-mutation

Dansker den f?rste med H1N1-mutation
29. jun 2009 15:58 En dansker har udviklet en muteret udgave af H1N1, der er resistent over for influenzamidlet Tamiflu. Det er den f?rste konstaterede mutation af H1N1 i verden
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Ritzau
Det f?rste tilf?lde i verden af resistens over for influenzamedicinen Tamiflu hos folk med influenza H1N1 er fundet i Danmark. Personen er nu rask, og der er ikke p?vist yderligere smitte med det resistente virus, oplyser Statens Serum Institut.

- Vi regner ikke med, at det eksisterer l?ngere, siger Nils Strandberg Pedersen, der er administrerende direkt?r ved Statens Serum Institut, og henviser til den muterede form af H1N1.

Den smittede dansker havde v?ret i t?t kontakt med en anden smittet person og var derfor i forebyggede behandling med Tamiflu. Alligevel fik personen influenzasymptomer og er i stedet behandlet med en anden type influenzamedicin, Relenza.

If?lge Niels Strandberg Pedersen er det ikke af betydning, at den f?rste muterede version er fundet i Danmark.

- Vi opfatter det som et udtryk for, at vores overv?gninger fungerer, siger han.

Verdens sundhedsorganisationen WHO opfordrer efter det danske tilf?lde til mere opm?rksomhed p? mulighed for udvikling af resistens hos viruset.

Det er ikke us?dvanligt, at en influenzavirus muterer spontant, og i en pressemeddelelse kalder Statens Serum Institut det "Velkendt og forventeligt." Samtidig kan Niels Strandberg Pedersen ikke udelukke, at der vil komme nye former for mutation.

Til behandling af H1N1 har Danmark store lagre af Tamiflu, og i slutningen af april blev der indk?bt 40.000 doser Relenza som en ekstra sikkerhed i tilf?lde af resistente mutationer.

[wotan]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

I didn't see anything on their website. However, if the patients was NOT treated with Tamiflu, then the polymorphism (likely H274Y) was NOT selected and the virus with the change is fit.

I'm reading it as treatment with Tamiflu was begun but was not effective, and therefore they started Relenza.

We need the sequence to be published.

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Dane first with H1N1-mutation

/ Ritzau /

Last updated on Monday 29th June 2009, 15:58

The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark. The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

- We do not expect that the longer exist, says Nils Strandberg Pedersen, Managing Director, Statens Serum Institut, and refers to the mutated form of H1N1. The infected Dane had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu.

Yet the person had flu symptoms and are instead treated with another type of flu drugs, Relenza.

According to Niels Strandberg Pedersen, it is not significant that the first mutated version is found in Denmark. - We see it as an expression of our monitoring work, he said. World Health Organization Calls for the Danish case for more attention to the possibility of development of resistance in the virus.

It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected." At the same time, Niels Strandberg Pedersen not exclude that there will be new forms of mutation. For the treatment of H1N1, Denmark has large stockpiles of Tamiflu, and in late April were purchased 40,000 doses of Relenza for additional security in cases of resistant mutations.

http://www.horsens-folkeblad.dk/?rartikel=K2JN-7TGHD8201175

[Gert van der Hoek]

Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu

Articles say no spreading of this resistant strain was found.

Articles also say the man was treated with Tamiflu first, but kept displaying symptoms, than he was treated with Relenza. And was cured.